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RPS2 and SMN1
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
0
Data Source:
BioGRID
(two hybrid)
RPS2
SMN1
Description
ribosomal protein S2
survival of motor neuron 1, telomeric
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Ribosome
Focal Adhesion
Small Ribosomal Subunit
Membrane
Cytosolic Ribosome
Cytosolic Small Ribosomal Subunit
Extracellular Exosome
Ribonucleoprotein Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cajal Body
Nuclear Body
Z Disc
Axon
SMN Complex
SMN-Sm Protein Complex
Cytoplasmic Ribonucleoprotein Granule
Cell Projection
Neuron Projection
Perikaryon
Gemini Of Cajal Bodies
Molecular Function
RNA Binding
MRNA Binding
Structural Constituent Of Ribosome
Protein Binding
Fibroblast Growth Factor Binding
Enzyme Binding
Cadherin Binding
RNA Binding
Protein Binding
Identical Protein Binding
Biological Process
Cytoplasmic Translation
Translation
Positive Regulation Of Ubiquitin-protein Transferase Activity
Spliceosomal Complex Assembly
RNA Splicing, Via Transesterification Reactions
Spliceosomal SnRNP Assembly
DNA-templated Transcription Termination
MRNA Processing
Nervous System Development
RNA Splicing
Pathways
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Selenocysteine synthesis
RMTs methylate histone arginines
rRNA modification in the nucleus and cytosol
Major pathway of rRNA processing in the nucleolus and cytosol
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Protein methylation
Regulation of expression of SLITs and ROBOs
Response of EIF2AK4 (GCN2) to amino acid deficiency
SARS-CoV-1 modulates host translation machinery
SARS-CoV-2 modulates host translation machinery
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
snRNP Assembly
SARS-CoV-2 modulates host translation machinery
Drugs
Copper
Nusinersen
Diseases
Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS
Atrial fibrillation (
29892015
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Interacting Genes
24 interacting genes:
ANXA2
ANXA7
CDKN1A
DNM2
DUX4
FBXO7
FGF1
FGF3
FXR2
GABARAPL2
GADD45A
GRB7
GSK3B
MPP3
OGT
PTEN
SAYSD1
SMN1
SOX5
TK1
TRAF6
USP47
WEE2-AS1
YWHAG
166 interacting genes:
A1BG
A2M
ACTB
ACTL6B
ADAMTS10
AGAP1
ANXA2
APLP1
ARFGAP1
ATP5F1B
ATP6V1A
BAG6
BCL2
BLOC1S6
BYSL
CARHSP1
CCDC90B
CENPB
CHTOP
COIL
COL4A2
COL4A5
COPS6
CPNE6
CRIP2
CSAD
DDAH2
DDX20
DHX9
DMPK
DOCK7
DUS2
DYNC1I1
EEF1A1
EEF1A2
EHHADH
EIF3G
EXT2
EZH2
FAM20C
FAM9B
FBL
FGB
FLAD1
FNDC11
FUBP1
FXR1
GAPDH
GAR1
GDF9
GEMIN2
GEMIN5
GEMIN7
H3-4
HADHB
HMGXB3
HNRNPR
HNRNPU
HNRNPUL1
IGHM
ILF3
IMMT
INPP5K
IQUB
ITCH
JADE1
KDM1A
KIF5A
KLHL5
KMT2B
KPNB1
KRTAP19-6
KRTAP19-7
KRTAP21-2
KRTAP6-1
KRTAP6-2
LENG8
LRIF1
LSM1
LSM10
LSM11
LSM2
LSM3
LSM4
LSM5
LSM6
LSM7
MAGED1
MAST2
MED31
MKI67
MPP1
MRPL37
MSH2
NEURL2
NGFR
NKIRAS2
NMT2
NRN1
NTAQ1
OSTF1
PDE4DIP
PKM
PLXNA3
POLR1C
POLR2A
POP7
PPIG
PSME1
QARS1
RBBP4
RBBP6
RBFOX2
RBM48
REX1BD
RN7SL1
RNU1-1
RNU11
RNU2-1
RNU4-1
RPL13
RPS2
RXRA
SCARNA1
SDF4
SELENOW
SEMA5B
SETDB1
SMC5
SMN2
SNORA81
SNRPB
SNRPD1
SNRPD2
SNRPD3
SNRPE
SNU13
SNUPN
SP110
SPANXN2
STRAP
STXBP2
STXBP3
SULT1A3
SUMO3
SYNCRIP
TAF1C
TERC
TIAL1
TLE1
TMSB4X
TP53
TRMT2A
TUBA1A
TUBB3
UCHL1
UNC119
USP4
VPS28
WDR18
WDR73
WIZ
ZBTB16
ZNF431
ZRANB2
ZXDC
Entrez ID
6187
6606
HPRD ID
04690
02646
Ensembl ID
ENSG00000140988
ENSG00000172062
Uniprot IDs
P15880
B4DP61
E7EQZ4
Q16637
PDB IDs
4UG0
4V6X
5A2Q
5AJ0
5FLX
5LKS
5OA3
5T2C
5VYC
6G18
6G4S
6G51
6G53
6G5H
6G5I
6IP5
6IP6
6IP8
6OLE
6OLF
6OLG
6OLI
6OLZ
6OM0
6OM7
6QZP
6XA1
6Y0G
6Y2L
6Y57
6YBD
6YBW
6Z6L
6Z6M
6Z6N
6ZLW
6ZM7
6ZME
6ZMI
6ZMO
6ZMT
6ZMW
6ZN5
6ZOJ
6ZOK
6ZON
6ZP4
6ZUO
6ZV6
6ZVH
6ZVJ
6ZXD
6ZXE
6ZXF
6ZXG
6ZXH
7A09
7JQB
7JQC
7K5I
7QP6
7QP7
7QVP
7R4X
7TQL
7WTV
7WTW
7WTX
7WTZ
7WU0
7XNX
7XNY
8G5Y
8G5Z
8G60
8G61
8G6J
8GLP
8IFD
8IFE
8JDJ
8JDK
8JDL
8JDM
8K2C
8OZ0
8PJ1
8PJ2
8PJ3
8PJ4
8PJ5
8PJ6
8PPK
8PPL
8QOI
8T4S
8UKB
8XP2
8XP3
8XSX
8XSY
8XSZ
8XXL
8XXM
8XXN
8Y0W
8Y0X
8YOO
8YOP
8ZDB
8ZDC
8ZDD
9BKD
9BLN
9C3H
9G8M
9G8O
1G5V
1MHN
2LEH
4A4E
4A4G
4GLI
4QQ6
5XJL
5XJQ
5XJR
5XJS
5XJT
5XJU
7W2P
7W30
Enriched GO Terms of Interacting Partners
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Negative Regulation Of Protein Metabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Developmental Process
Regulation Of Protein Modification Process
Positive Regulation Of Signaling
Negative Regulation Of Protein Phosphorylation
Regulation Of Phosphorus Metabolic Process
Regulation Of Protein Phosphorylation
Myelin Sheath Adaxonal Region
Regulation Of Protein Kinase Activity
Negative Regulation Of Protein Catabolic Process
Regulation Of Kinase Activity
Regulation Of Phosphorylation
Negative Regulation Of Phosphorylation
Cytosol
Positive Regulation Of Signal Transduction
Negative Regulation Of Peptidyl-serine Phosphorylation
Autophagy
Regulation Of Multicellular Organismal Process
Cytoplasm
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Signaling
Negative Regulation Of Catalytic Activity
Negative Regulation Of Phosphate Metabolic Process
Regulation Of Locomotion
Positive Regulation Of Translation
Regulation Of Mesenchymal Stem Cell Differentiation
Negative Regulation Of Proteasomal Protein Catabolic Process
Schmidt-Lanterman Incisure
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Cell Communication
Regulation Of Catalytic Activity
Negative Regulation Of Cell Cycle G1/S Phase Transition
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of Protein Kinase Activity
Negative Regulation Of Multicellular Organismal Process
Wound Healing
Autophagy Of Mitochondrion
S100 Protein Binding
Negative Regulation Of Metabolic Process
Regulation Of Proteolysis
Negative Regulation Of Kinase Activity
Positive Regulation Of Proteolysis
Negative Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Plasma Membrane Organization
TOR Signaling
Cellular Component Assembly
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Cellular Developmental Process
Spliceosomal SnRNP Assembly
RNA Binding
MRNA Metabolic Process
RNA Splicing
MRNA Processing
RNA Splicing, Via Transesterification Reactions
SMN-Sm Protein Complex
RNA Processing
Ribonucleoprotein Complex
U4/U6 X U5 Tri-snRNP Complex
Protein-RNA Complex Assembly
MRNA Splicing, Via Spliceosome
RNA Metabolic Process
U2-type Precatalytic Spliceosome
Spliceosomal Complex
Lsm2-8 Complex
Nucleobase-containing Compound Metabolic Process
Nucleic Acid Metabolic Process
U6 SnRNP
Lsm1-7-Pat1 Complex
Nucleoplasm
Precatalytic Spliceosome
SMN Complex
U4 SnRNP
Catalytic Step 2 Spliceosome
Telomerase Holoenzyme Complex
U7 SnRNP
Macromolecule Metabolic Process
7-methylguanosine Cap Hypermethylation
Small Nuclear Ribonucleoprotein Complex
Nucleus
Gemini Of Cajal Bodies
Methylosome
U12-type Spliceosomal Complex
PICln-Sm Protein Complex
Spliceosomal Tri-snRNP Complex
Cytosol
U2 SnRNP
Spliceosomal Complex Assembly
Protein-containing Complex Assembly
U1 SnRNP
U7 SnRNA Binding
U5 SnRNP
Cytoplasm
Cajal Body
Histone Pre-mRNA DCP Binding
U2-type Prespliceosome Assembly
Protein-containing Complex Organization
U6 SnRNA Binding
Promoter-specific Chromatin Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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