RPS2 and SAYSD1

Number of citations of the paper that reports this interaction (PubMedID 36848233)
56

Data Source:
BioGRID (pull down)

		RPS2	SAYSD1
Description		ribosomal protein S2	SAYSVFN motif domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Ribosome Focal Adhesion Small Ribosomal Subunit Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Extracellular Exosome Ribonucleoprotein Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	RNA Binding MRNA Binding Structural Constituent Of Ribosome Protein Binding Fibroblast Growth Factor Binding Enzyme Binding Cadherin Binding	UFM1-modified Protein Reader Activity
	Biological Process	Cytoplasmic Translation Translation Positive Regulation Of Ubiquitin-protein Transferase Activity	Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Rescue Of Stalled Ribosome
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis RMTs methylate histone arginines rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Protein methylation Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs		Copper
Diseases
GWAS		Atrial fibrillation ( 29892015) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Body mass index and systolic blood pressure (bivariate analysis) ( 33539483) Coronary artery disease ( 32469254) Diastolic blood pressure ( 27841878) Protein C levels ( 28082259)
Interacting Genes		24 interacting genes: ANXA2 ANXA7 CDKN1A DNM2 DUX4 FBXO7 FGF1 FGF3 FXR2 GABARAPL2 GADD45A GRB7 GSK3B MPP3 OGT PTEN SAYSD1 SMN1 SOX5 TK1 TRAF6 USP47 WEE2-AS1 YWHAG	5 interacting genes: HSPA8 RPL26 RPL5 RPS2 UFM1
Entrez ID		6187	55776
HPRD ID		04690	12892
Ensembl ID		ENSG00000140988	ENSG00000112167
Uniprot IDs		P15880	Q9NPB0
PDB IDs		4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6G18 6G4S 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBD 6YBW 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOK 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7JQB 7JQC 7K5I 7QP6 7QP7 7QVP 7R4X 7TQL 7WTV 7WTW 7WTX 7WTZ 7WU0 7XNX 7XNY 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Developmental Process Regulation Of Protein Modification Process Positive Regulation Of Signaling Negative Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Myelin Sheath Adaxonal Region Regulation Of Protein Kinase Activity Negative Regulation Of Protein Catabolic Process Regulation Of Kinase Activity Regulation Of Phosphorylation Negative Regulation Of Phosphorylation Cytosol Positive Regulation Of Signal Transduction Negative Regulation Of Peptidyl-serine Phosphorylation Autophagy Regulation Of Multicellular Organismal Process Cytoplasm Negative Regulation Of Macromolecule Metabolic Process Regulation Of Signaling Negative Regulation Of Catalytic Activity Negative Regulation Of Phosphate Metabolic Process Regulation Of Locomotion Positive Regulation Of Translation Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Proteasomal Protein Catabolic Process Schmidt-Lanterman Incisure Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Communication Regulation Of Catalytic Activity Negative Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Kinase Activity Negative Regulation Of Multicellular Organismal Process Wound Healing Autophagy Of Mitochondrion S100 Protein Binding Negative Regulation Of Metabolic Process Regulation Of Proteolysis Negative Regulation Of Kinase Activity Positive Regulation Of Proteolysis Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Plasma Membrane Organization TOR Signaling Cellular Component Assembly Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Developmental Process	Ribonucleoprotein Complex Cytosolic Ribosome Cytoplasmic Translation Structural Constituent Of Ribosome Ribosome MRNA 5'-UTR Binding Regulation Of Ubiquitin-protein Transferase Activity Nucleolus Ribosomal Large Subunit Biogenesis Translation Cytosolic Large Ribosomal Subunit Focal Adhesion Protein Metabolic Process Chaperone-mediated Autophagy Translocation Complex Disassembly RNA Binding Regulation Of Translation Involved In Cellular Response To UV Regulation Of Signal Transduction By P53 Class Mediator Lumenal Side Of Lysosomal Membrane Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Intracellular Signal Transduction Positive Regulation Of Translation Regulation Of Protein Import Extracellular Exosome Positive Regulation Of Protein Metabolic Process Ribonucleoprotein Complex Biogenesis Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy RNA Processing C3HC4-type RING Finger Domain Binding Clathrin Coat Disassembly Regulation Of Protein Ubiquitination RRNA Processing Negative Regulation Of Protein Neddylation Protein K69-linked Ufmylation ATP-dependent Protein Disaggregase Activity Vesicle Uncoating Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification RRNA Metabolic Process Chaperone-mediated Autophagy Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Ufmylation Autophagy Ubiquitin Protein Ligase Binding 5S RRNA Binding Cadherin Binding Negative Regulation Of Ubiquitin-protein Transferase Activity Ubiquitin Ligase Inhibitor Activity
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