NECAB2 and CCNK

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NECAB2	CCNK
Description		N-terminal EF-hand calcium binding protein 2	cyclin K
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Axon Dendrite Cell Projection Presynapse Postsynapse	Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin K-CDK12 Complex Cyclin K-CDK13 Complex Nucleus Nucleoplasm Cyclin/CDK Positive Transcription Elongation Factor Complex
	Molecular Function	Calcium Ion Binding Protein Binding A2A Adenosine Receptor Binding Type 5 Metabotropic Glutamate Receptor Binding Identical Protein Binding Metal Ion Binding	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Adenosine Receptor Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Glutamate Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Protein Localization To Membrane	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II DNA Damage Response Regulation Of Signal Transduction Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II Host-mediated Suppression Of Viral Genome Replication Positive Regulation Of Transcription By RNA Polymerase II Cell Division Regulation Of Cell Cycle
Pathways			Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat HIV elongation arrest and recovery Pausing and recovery of HIV elongation SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Body mass index (change over time) ( 25378290) Corneal astigmatism ( 29422769) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Rheumatoid arthritis ( 30891314)	Scalp hair shape ( 26926045) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		91 interacting genes: ADORA2A AIMP2 AIRIM BEX2 BEX3 BYSL C19orf25 C1orf216 CAGE1 CAPN3 CARD9 CCDC121 CCDC146 CCDC33 CCNK CDC37 CENPO CPEB2 DAXX DFFA DGCR6 DGCR6L DRC12 DTNBP1 DYNC1I2 EAF2 EHHADH EIF4E2 EMILIN1 FAM161A FAM161B FANCG FMR1 FXR1 FXR2 GCC1 GOLGA2 GTPBP10 HAUS1 INPP1 INTS10 ISCU KANK2 KANSL1 KDM1A KIFC3 KLC3 KLC4 KPNA2 LENG1 LNX1 MED14 MRPS27 MSGN1 MTCL2 MTMR9 MYO15B MYPOP NEK6 NIP7 NOC4L NTAQ1 ODAD3 ODAD4 OIP5 PATJ PICK1 POLR2C PRKAA2 PRPF18 PSMA1 PUS10 RCOR3 RIC8A RUNX1T1 SDCBP SH2D4A SMARCA2 SMARCD1 SNAPIN SSC5D TCEA2 TEX11 TRIM59 TRIML2 TSC1 TTR USHBP1 USP7 VTA1 ZNF655	54 interacting genes: ATXN1 BHLHE40 CCDC85B CDK18 CDK2 CDK9 CEP76 CYSRT1 DDB1 DDIT4L DVL3 EFEMP2 FAM168B FKBP6 HIVEP1 HMG20A HNRNPH1 HNRNPH2 HOMEZ HOXA1 HSFY1 HSFY2 KCNRG KRTAP13-2 KRTAP19-6 KRTAP19-7 KRTAP4-12 KRTAP6-2 KRTAP8-1 LZTS2 MYCL NDC80 NECAB2 OXER1 PIN1 POLR1C POLR2A POU6F2 PRR20A PRR20B PRR20C PRR20D PRR20E RBPMS RBX1 RFX6 RHOXF2 RUNX1 STX11 TLE5 TSC22D4 USHBP1 USP54 ZNF446
Entrez ID		54550	8812
HPRD ID		13263	10352
Ensembl ID		ENSG00000103154	ENSG00000090061
Uniprot IDs		Q7Z6G3	O75909
PDB IDs			2I53 4CXA 4NST 4UN0 5ACB 5EFQ 6B3E 6CKX 6TD3 7NXJ 7NXK 8BU1 8BU2 8BU3 8BU4 8BU5 8BU6 8BU7 8BU9 8BUA 8BUB 8BUC 8BUD 8BUE 8BUF 8BUG 8BUH 8BUI 8BUJ 8BUK 8BUL 8BUM 8BUN 8BUO 8BUP 8BUQ 8BUR 8BUS 8BUT 8P81 9FMR
Enriched GO Terms of Interacting Partners?		Protein Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Translation Regulator Activity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Presynaptic Modulation Of Chemical Synaptic Transmission Cytoplasm Microtubule Outer Dynein Arm Docking Complex Cellular Component Assembly Microtubule-based Movement Spermatid Development Regulation Of DNA-templated Transcription Elongation RNA Strand Annealing Activity Regulation Of Long-term Neuronal Synaptic Plasticity Organelle Assembly Ribosome Biogenesis Positive Regulation Of Receptor Internalization	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Intermediate Filament Regulation Of RNA Metabolic Process DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cyclin-dependent Protein Serine/threonine Kinase Activity Base-excision Repair, AP Site Formation Via Deaminated Base Removal Cul4B-RING E3 Ubiquitin Ligase Complex Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Identical Protein Binding Regulation Of Primary Metabolic Process Transcription Elongation By RNA Polymerase II Spindle Assembly Involved In Female Meiosis DNA-templated Transcription Elongation Regulation Of Macromolecule Metabolic Process Cul4A-RING E3 Ubiquitin Ligase Complex
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