NECAB2 and CCDC121

Number of citations of the paper that reports this interaction (PubMedID 21516116)
20

Data Source:
BioGRID (two hybrid)

		NECAB2	CCDC121
Description		N-terminal EF-hand calcium binding protein 2	coiled-coil domain containing 121
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Axon Dendrite Cell Projection Presynapse Postsynapse
	Molecular Function	Calcium Ion Binding Protein Binding A2A Adenosine Receptor Binding Type 5 Metabotropic Glutamate Receptor Binding Identical Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Adenosine Receptor Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Glutamate Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Protein Localization To Membrane
Pathways
Drugs
Diseases
GWAS		Body mass index (change over time) ( 25378290) Corneal astigmatism ( 29422769) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Rheumatoid arthritis ( 30891314)	Bipolar disorder ( 31043756) Metabolite levels ( 23823483) Oral cavity cancer ( 27749845) Triglycerides ( 26160806) Waist Circumference - Triglycerides (WC-TG) ( 21386085)
Interacting Genes		91 interacting genes: ADORA2A AIMP2 AIRIM BEX2 BEX3 BYSL C19orf25 C1orf216 CAGE1 CAPN3 CARD9 CCDC121 CCDC146 CCDC33 CCNK CDC37 CENPO CPEB2 DAXX DFFA DGCR6 DGCR6L DRC12 DTNBP1 DYNC1I2 EAF2 EHHADH EIF4E2 EMILIN1 FAM161A FAM161B FANCG FMR1 FXR1 FXR2 GCC1 GOLGA2 GTPBP10 HAUS1 INPP1 INTS10 ISCU KANK2 KANSL1 KDM1A KIFC3 KLC3 KLC4 KPNA2 LENG1 LNX1 MED14 MRPS27 MSGN1 MTCL2 MTMR9 MYO15B MYPOP NEK6 NIP7 NOC4L NTAQ1 ODAD3 ODAD4 OIP5 PATJ PICK1 POLR2C PRKAA2 PRPF18 PSMA1 PUS10 RCOR3 RIC8A RUNX1T1 SDCBP SH2D4A SMARCA2 SMARCD1 SNAPIN SSC5D TCEA2 TEX11 TRIM59 TRIML2 TSC1 TTR USHBP1 USP7 VTA1 ZNF655	7 interacting genes: KDM1A NECAB2 NUP62 RINT1 TFIP11 TNIP1 USHBP1
Entrez ID		54550	79635
HPRD ID		13263	07834
Ensembl ID		ENSG00000103154	ENSG00000176714
Uniprot IDs		Q7Z6G3	Q6ZUS5
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Translation Regulator Activity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Presynaptic Modulation Of Chemical Synaptic Transmission Cytoplasm Microtubule Outer Dynein Arm Docking Complex Cellular Component Assembly Microtubule-based Movement Spermatid Development Regulation Of DNA-templated Transcription Elongation RNA Strand Annealing Activity Regulation Of Long-term Neuronal Synaptic Plasticity Organelle Assembly Ribosome Biogenesis Positive Regulation Of Receptor Internalization	Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Deubiquitination Negative Regulation Of Intracellular Signal Transduction Response To Fungicide MRF Binding Negative Regulation Of Cellular Component Organization Histone H3K4 Demethylase Activity Regulation Of Double-strand Break Repair Guanine Metabolic Process Protein Demethylase Activity Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Chromosome, Telomeric Region PTB Domain Binding Nuclear Pore Central Transport Channel Positive Regulation Of Mitotic Cytokinetic Process Positive Regulation Of Protein Localization To Centrosome Mitotic Centrosome Separation Spliceosomal Complex Disassembly Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Protection From Non-homologous End Joining At Telomere U2-type Post-mRNA Release Spliceosomal Complex Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Adenosine Receptor Signaling Pathway Type 5 Metabotropic Glutamate Receptor Binding A2A Adenosine Receptor Binding Dsl1/NZR Complex Regulation Of Protein Deubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Post-translational Protein Modification Histone H3K9 Demethylase Activity Positive Regulation Of Cell Size Regulation Of Protein Localization Regulation Of DNA Repair Positive Regulation Of Centriole Replication Centrosome Separation Regulation Of Protein Localization To Centrosome Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Glutamate Receptor Signaling Pathway Regulation Of ER To Golgi Vesicle-mediated Transport
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