NECAB2 and HAUS1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		NECAB2	HAUS1
Description		N-terminal EF-hand calcium binding protein 2	HAUS augmin like complex subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Axon Dendrite Cell Projection Presynapse Postsynapse	Spindle Pole Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microtubule HAUS Complex Mitotic Spindle Microtubule
	Molecular Function	Calcium Ion Binding Protein Binding A2A Adenosine Receptor Binding Type 5 Metabotropic Glutamate Receptor Binding Identical Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Adenosine Receptor Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Glutamate Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Protein Localization To Membrane	Centrosome Cycle Regulation Of Microtubule Nucleation Spindle Assembly Cell Division
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Body mass index (change over time) ( 25378290) Corneal astigmatism ( 29422769) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Rheumatoid arthritis ( 30891314)
Interacting Genes		91 interacting genes: ADORA2A AIMP2 AIRIM BEX2 BEX3 BYSL C19orf25 C1orf216 CAGE1 CAPN3 CARD9 CCDC121 CCDC146 CCDC33 CCNK CDC37 CENPO CPEB2 DAXX DFFA DGCR6 DGCR6L DRC12 DTNBP1 DYNC1I2 EAF2 EHHADH EIF4E2 EMILIN1 FAM161A FAM161B FANCG FMR1 FXR1 FXR2 GCC1 GOLGA2 GTPBP10 HAUS1 INPP1 INTS10 ISCU KANK2 KANSL1 KDM1A KIFC3 KLC3 KLC4 KPNA2 LENG1 LNX1 MED14 MRPS27 MSGN1 MTCL2 MTMR9 MYO15B MYPOP NEK6 NIP7 NOC4L NTAQ1 ODAD3 ODAD4 OIP5 PATJ PICK1 POLR2C PRKAA2 PRPF18 PSMA1 PUS10 RCOR3 RIC8A RUNX1T1 SDCBP SH2D4A SMARCA2 SMARCD1 SNAPIN SSC5D TCEA2 TEX11 TRIM59 TRIML2 TSC1 TTR USHBP1 USP7 VTA1 ZNF655	82 interacting genes: AK8 ARFIP2 ATP6V1D BFSP2 BLOC1S6 BORCS6 C3orf62 CAGE1 CBY2 CCDC136 CCDC57 CCHCR1 CDR2 CENPP CEP170P1 CEP44 CEP55 CEP57L1 CEP63 CEP70 DCTN2 DMD DTNBP1 FAM161B FGFR1OP2 GOLGA2 HGS HOOK2 IFIT3 IFT20 INCA1 KDM1A KIFC3 KRT1 KRT15 KRT18 KRT19 KRT3 KRT31 KRT38 KRT40 KXD1 LDOC1 LURAP1 MAD1L1 MAGEA6 MCM10 MCM3 MED4 MED7 MIPOL1 MTUS2 NDC80 NECAB2 NINL NUP54 NUP62 ODAD1 PDE4DIP PIBF1 PKN1 POLR3C SPAG5 SSC5D STX11 SYCE1 SYCE3 TEAD4 TFIP11 TFPT TRAF1 TRIM23 TRIM27 TRIM54 TRIM69 TSG101 TXN2 USHBP1 VPS37C VPS52 WASHC3 ZNF471
Entrez ID		54550	115106
HPRD ID		13263	16385
Ensembl ID		ENSG00000103154	ENSG00000152240
Uniprot IDs		Q7Z6G3	Q96CS2
PDB IDs			7SQK
Enriched GO Terms of Interacting Partners?		Protein Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Translation Regulator Activity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Presynaptic Modulation Of Chemical Synaptic Transmission Cytoplasm Microtubule Outer Dynein Arm Docking Complex Cellular Component Assembly Microtubule-based Movement Spermatid Development Regulation Of DNA-templated Transcription Elongation RNA Strand Annealing Activity Regulation Of Long-term Neuronal Synaptic Plasticity Organelle Assembly Ribosome Biogenesis Positive Regulation Of Receptor Internalization	Cytoskeleton Organelle Organization Centrosome Microtubule-based Process Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Cytoskeleton Organization Intermediate Filament Organization Protein Binding Structural Constituent Of Skin Epidermis Keratin Filament Organelle Assembly Intermediate Filament Identical Protein Binding Microtubule Organizing Center Organization Establishment Of Localization In Cell Supramolecular Fiber Organization Organelle Localization Intracellular Transport Centrosome Cycle Microtubule Binding Intracellular Protein Localization Protein Localization To Centrosome Metaphase Chromosome Alignment Cellular Component Assembly Protein Transport Cilium Organization Centriole Assembly Spindle Organization Cellular Localization Structural Molecule Activity Establishment Of Protein Localization Cilium Assembly Microtubule Establishment Of Organelle Localization Chromosome Localization BLOC-1 Complex Plasma Membrane Bounded Cell Projection Assembly Microtubule Cytoskeleton Organization Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cell Projection Assembly Mitotic Metaphase Chromosome Alignment Protein Localization To Cytoskeleton Spindle Pole Structural Constituent Of Cytoskeleton Vesicle Organization Centriole Centriole Replication Protein Localization To Organelle Endosomal Transport
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