NECAB2 and INPP1

Number of citations: 69 (PubMedID 24722188)
Data Source: BioGRID (two hybrid)

		NECAB2	INPP1
Name		N-terminal EF-hand calcium binding protein 2	inositol polyphosphate-1-phosphatase
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Axon Dendrite Cell Projection Presynapse Postsynapse	Cytosol
	Molecular Function	Calcium Ion Binding Protein Binding A2A Adenosine Receptor Binding Type 5 Metabotropic Glutamate Receptor Binding Identical Protein Binding Metal Ion Binding	Inositol-1,4-bisphosphate 1-phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding Inositol-1,3,4-trisphosphate 1-phosphatase Activity
	Biological Process	Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Adenosine Receptor Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Glutamate Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Protein Localization To Membrane	Phosphate-containing Compound Metabolic Process Signal Transduction Phosphatidylinositol Phosphate Biosynthetic Process
Pathways		None	Synthesis of IP2, IP, and Ins in the cytosol
GWAS		Body mass index (change over time) ( 25378290 ) Corneal astigmatism ( 29422769 ) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872 ) Rheumatoid arthritis ( 30891314 )	Arthritis (juvenile idiopathic) ( 33106285 ) Daytime sleep phenotypes ( 27126917 ) Lung cancer (SNP x SNP interaction) ( 24325914 ) Machado-Joseph disease (age at onset) ( 32205469 )
Interacting Genes		91 interacting genes: ADORA2A AIMP2 AIRIM BEX2 BEX3 BYSL C19orf25 C1orf216 CAGE1 CAPN3 CARD9 CCDC121 CCDC146 CCDC33 CCNK CDC37 CENPO CPEB2 DAXX DFFA DGCR6 DGCR6L DRC12 DTNBP1 DYNC1I2 EAF2 EHHADH EIF4E2 EMILIN1 FAM161A FAM161B FANCG FMR1 FXR1 FXR2 GCC1 GOLGA2 GTPBP10 HAUS1 INPP1 INTS10 ISCU KANK2 KANSL1 KDM1A KIFC3 KLC3 KLC4 KPNA2 LENG1 LNX1 MED14 MRPS27 MSGN1 MTCL2 MTMR9 MYO15B MYPOP NEK6 NIP7 NOC4L NTAQ1 ODAD3 ODAD4 OIP5 PATJ PICK1 POLR2C PRKAA2 PRPF18 PSMA1 PUS10 RCOR3 RIC8A RUNX1T1 SDCBP SH2D4A SMARCA2 SMARCD1 SNAPIN SSC5D TCEA2 TEX11 TRIM59 TRIML2 TSC1 TTR USHBP1 USP7 VTA1 ZNF655	11 interacting genes: BBLN BRCA1 DYNLL1 LDOC1 LIG1 MEOX2 NDC80 NECAB2 NR1D1 SYCE3 USHBP1
Entrez ID		54550	3628
HPRD ID		13263	00923
Ensembl ID		ENSG00000103154	ENSG00000151689
Uniprot IDs		Q7Z6G3	P49441 Q6IBG4
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Protein Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Translation Regulator Activity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Presynaptic Modulation Of Chemical Synaptic Transmission Cytoplasm Microtubule Outer Dynein Arm Docking Complex Cellular Component Assembly Microtubule-based Movement Spermatid Development Regulation Of DNA-templated Transcription Elongation RNA Strand Annealing Activity Regulation Of Long-term Neuronal Synaptic Plasticity Organelle Assembly Ribosome Biogenesis Positive Regulation Of Receptor Internalization	DNA Strand Resection Involved In Replication Fork Processing Histone H2AK127 Ubiquitin Ligase Activity DNA Metabolic Process Histone H2AK129 Ubiquitin Ligase Activity Homologous Recombination Cellular Response To Tumor Necrosis Factor Chromosome BRCA1-BARD1 Complex DNA Recombination Okazaki Fragment Processing Involved In Mitotic DNA Replication DNA Ligase (ATP) Activity Lagging Strand Elongation DNA Replication, Okazaki Fragment Processing DNA Ligase Activity Deoxyribonuclease Inhibitor Activity Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Negative Regulation Of Astrocyte Activation Circadian Temperature Homeostasis Positive Regulation Of Bile Acid Biosynthetic Process G2/MI Transition Of Meiotic Cell Cycle Kinetochore Adaptor Activity Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Adenosine Receptor Signaling Pathway A2A Adenosine Receptor Binding Subapical Part Of Cell Multinuclear Osteoclast Differentiation BRCA1-B Complex Cell Division Meiotic Cell Cycle Phase Transition Ndc80 Complex Spindle Assembly Involved In Female Meiosis I Type 5 Metabotropic Glutamate Receptor Binding Response To Tumor Necrosis Factor