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MAPK8IP3 and TLR4
Number of citations of the paper that reports this interaction (PMID
12941697
)
17
Data Source:
HPRD
(in vivo)
MAPK8IP3
TLR4
Gene Name
mitogen-activated protein kinase 8 interacting protein 3
toll-like receptor 4
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Cytoplasm
Smooth Endoplasmic Reticulum
Dendrite
Axolemma
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Endosome Membrane
Lipopolysaccharide Receptor Complex
Perinuclear Region Of Cytoplasm
Molecular Function
MAP-kinase Scaffold Activity
JUN Kinase Binding
Kinesin Binding
Receptor Signaling Complex Scaffold Activity
Mitogen-activated Protein Kinase Kinase Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Lipopolysaccharide Binding
Lipopolysaccharide Receptor Activity
Receptor Activity
Transmembrane Signaling Receptor Activity
Protein Binding
Biological Process
In Utero Embryonic Development
Activation Of JUN Kinase Activity
Axon Guidance
Respiratory Gaseous Exchange
Protein Localization
Post-embryonic Development
Regulation Of Gene Expression
Vesicle-mediated Transport
Forebrain Development
Positive Regulation Of Neuron Differentiation
Regulation Of JNK Cascade
Lung Alveolus Development
Lung Morphogenesis
Activation Of MAPK Activity
Toll-like Receptor Signaling Pathway
B Cell Proliferation Involved In Immune Response
Nitric Oxide Production Involved In Inflammatory Response
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Immune Response
I-kappaB Kinase/NF-kappaB Signaling
I-kappaB Phosphorylation
Positive Regulation Of Platelet Activation
Detection Of Fungus
Positive Regulation Of B Cell Proliferation
Lipopolysaccharide-mediated Signaling Pathway
Response To Lipopolysaccharide
Detection Of Lipopolysaccharide
Interferon-gamma Production
Negative Regulation Of Interferon-gamma Production
Negative Regulation Of Interleukin-17 Production
Negative Regulation Of Interleukin-23 Production
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Chemokine Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-1 Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
T-helper 1 Type Immune Response
Macrophage Activation
Positive Regulation Of NF-kappaB Import Into Nucleus
Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process
Defense Response To Bacterium
Positive Regulation Of Interleukin-12 Biosynthetic Process
Innate Immune Response
Positive Regulation Of MHC Class II Biosynthetic Process
Positive Regulation Of Interferon-beta Biosynthetic Process
Positive Regulation Of Interleukin-8 Biosynthetic Process
Positive Regulation Of Nitric Oxide Biosynthetic Process
Negative Regulation Of Osteoclast Differentiation
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of JNK Cascade
Regulation Of Cytokine Secretion
Positive Regulation Of Inflammatory Response
Defense Response To Gram-negative Bacterium
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Intestinal Epithelial Structure Maintenance
Positive Regulation Of Macrophage Cytokine Production
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway
Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Cellular Response To Lipopolysaccharide
Cellular Response To Lipoteichoic Acid
Cellular Response To Mechanical Stimulus
Pathways
TRAF6 mediated induction of TAK1 complex
TRIF-mediated TLR3/TLR4 signaling
IKK complex recruitment mediated by RIP1
MyD88-independent cascade
Toll Like Receptor TLR6:TLR2 Cascade
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Toll Like Receptor 2 (TLR2) Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
Toll-Like Receptors Cascades
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 3 (TLR3) Cascade
MyD88:Mal cascade initiated on plasma membrane
TRIF-mediated programmed cell death
Innate Immune System
Drugs
Diseases
GWAS
Obesity-related traits (
23251661
)
Protein-Protein Interactions
21 interactors:
ARL4D
CASP3
KLC1
KLC2
MAP2K1
MAP2K4
MAP2K7
MAP3K11
MAP3K5
MAPK10
MAPK8
MAPK8IP1
MAPK8IP2
MAPK9
PTK2
RAF1
RIC8A
SRC
TLR2
TLR4
TLR9
24 interactors:
BCL10
BTK
CD14
CNPY4
DEFB4A
HMGB1
HSP90B1
IRAK1
IRAK2
LY96
MAPK8IP3
MYD88
NOX4
RIPK2
RNF216
SERTAD1
SIGIRR
SMAD3
SYK
TICAM2
TIRAP
TLR1
TLR5
TOLLIP
Entrez ID
23162
7099
HPRD ID
12014
04325
Ensembl ID
ENSG00000138834
ENSG00000136869
Uniprot IDs
E9PFH7
Q9UPT6
O00206
PDB IDs
2Z62
2Z63
2Z65
2Z66
3FXI
3UL7
3UL8
3UL9
3ULA
4G8A
Enriched GO Terms of Interacting Partners
?
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
MyD88-dependent Toll-like Receptor Signaling Pathway
MAPK Cascade
JNK Cascade
Positive Regulation Of Signal Transduction
Regulation Of Protein Kinase Activity
Signal Transduction By Phosphorylation
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Regulation Of Kinase Activity
Toll-like Receptor Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Regulation Of Stress-activated MAPK Cascade
Regulation Of Protein Phosphorylation
Regulation Of MAPK Cascade
Immune Response-regulating Signaling Pathway
Positive Regulation Of Protein Kinase Activity
Intracellular Signal Transduction
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Positive Regulation Of Kinase Activity
Positive Regulation Of Catalytic Activity
Positive Regulation Of Protein Metabolic Process
Activation Of Innate Immune Response
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
Regulation Of Phosphorylation
Positive Regulation Of Transferase Activity
Regulation Of JNK Cascade
Regulation Of Protein Metabolic Process
Innate Immune Response
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of MAP Kinase Activity
Response To Stress
Positive Regulation Of Innate Immune Response
Phosphorylation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Phosphorylation
Regulation Of Phosphorus Metabolic Process
Regulation Of Catalytic Activity
Positive Regulation Of Protein Modification Process
Toll-like Receptor 9 Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of MAP Kinase Activity
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Positive Regulation Of Innate Immune Response
Inflammatory Response
Innate Immune Response
Regulation Of Innate Immune Response
Defense Response
MyD88-dependent Toll-like Receptor Signaling Pathway
Immune Response
Immune Response-regulating Signaling Pathway
Response To Other Organism
Response To Biotic Stimulus
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Immune Response
Response To Bacterium
Regulation Of Immune Response
Cellular Response To Molecule Of Bacterial Origin
Regulation Of Cytokine Production
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Response To Stress
Regulation Of Immune System Process
Response To Molecule Of Bacterial Origin
Immune System Process
Positive Regulation Of Immune System Process
Response To External Stimulus
I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Cytokine Production
Positive Regulation Of Protein Metabolic Process
Cellular Response To Lipopolysaccharide
Regulation Of Protein Metabolic Process
Response To Lipopolysaccharide
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Signal Transduction
Positive Regulation Of NF-kappaB Transcription Factor Activity
TRIF-dependent Toll-like Receptor Signaling Pathway
Response To Organic Substance
MyD88-independent Toll-like Receptor Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
Toll-like Receptor 3 Signaling Pathway
JNK Cascade
Cellular Response To Stimulus
Lipopolysaccharide-mediated Signaling Pathway
Regulation Of Phosphorylation
Regulation Of Cytokine Biosynthetic Process
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Signal Transduction
Tagcloud
?
bed
cd14
constitutively
fibroblast
immunoassay
immunocytochemistry
lamina
lipopolysaccharide
lps
md
measuring
microorganisms
nucleus
p65
polyp
propria
quantified
respond
responsiveness
scar
strategic
supernatant
tlr1
tlr9
tlrs
toll
vff
vffs
vocal
Tagcloud (Difference)
?
bed
cd14
constitutively
fibroblast
immunoassay
immunocytochemistry
lamina
lipopolysaccharide
lps
md
measuring
microorganisms
nucleus
p65
polyp
propria
quantified
respond
responsiveness
scar
strategic
supernatant
tlr1
tlr9
tlrs
toll
vff
vffs
vocal
Tagcloud (Intersection)
?