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MAPK8IP3 and TLR9
Number of citations of the paper that reports this interaction (PMID
12941697
)
17
Data Source:
HPRD
(in vivo)
MAPK8IP3
TLR9
Gene Name
mitogen-activated protein kinase 8 interacting protein 3
toll-like receptor 9
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Cytoplasm
Smooth Endoplasmic Reticulum
Dendrite
Axolemma
Golgi Membrane
Extracellular Region
Cytoplasm
Lysosome
Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Plasma Membrane
Endosome Membrane
Integral Component Of Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Early Phagosome
Endolysosome Membrane
Molecular Function
MAP-kinase Scaffold Activity
JUN Kinase Binding
Kinesin Binding
Receptor Signaling Complex Scaffold Activity
Mitogen-activated Protein Kinase Kinase Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Transmembrane Signaling Receptor Activity
Interleukin-1 Receptor Binding
SiRNA Binding
Biological Process
In Utero Embryonic Development
Activation Of JUN Kinase Activity
Axon Guidance
Respiratory Gaseous Exchange
Protein Localization
Post-embryonic Development
Regulation Of Gene Expression
Vesicle-mediated Transport
Forebrain Development
Positive Regulation Of Neuron Differentiation
Regulation Of JNK Cascade
Lung Alveolus Development
Lung Morphogenesis
Toll-like Receptor Signaling Pathway
Response To Molecule Of Bacterial Origin
MyD88-dependent Toll-like Receptor Signaling Pathway
Inflammatory Response
I-kappaB Phosphorylation
Insulin Receptor Signaling Pathway
Maintenance Of Gastrointestinal Epithelium
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Interleukin-8 Production
Positive Regulation Of Chemokine Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-18 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Toll-like Receptor Signaling Pathway
Positive Regulation Of Toll-like Receptor Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Positive Regulation Of NF-kappaB Import Into Nucleus
Defense Response To Bacterium
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Interferon-gamma Biosynthetic Process
Innate Immune Response
Positive Regulation Of Interferon-alpha Biosynthetic Process
Positive Regulation Of Interferon-beta Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of JNK Cascade
Regulation Of Cytokine Secretion
Positive Regulation Of Inflammatory Response
Defense Response To Gram-negative Bacterium
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Pathways
Insulin receptor signalling cascade
IRS-mediated signalling
Toll Like Receptor 7/8 (TLR7/8) Cascade
IRS-related events
IGF1R signaling cascade
IRS-related events triggered by IGF1R
Trafficking and processing of endosomal TLR
Toll-Like Receptors Cascades
IRS-mediated signalling
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
MyD88 dependent cascade initiated on endosome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
Toll Like Receptor 9 (TLR9) Cascade
PI3K Cascade
PI3K Cascade
Innate Immune System
Signaling by Insulin receptor
Drugs
Chloroquine
Hydroxychloroquine
Diseases
GWAS
Bipolar disorder (
21926972
)
Protein-Protein Interactions
21 interactors:
ARL4D
CASP3
KLC1
KLC2
MAP2K1
MAP2K4
MAP2K7
MAP3K11
MAP3K5
MAPK10
MAPK8
MAPK8IP1
MAPK8IP2
MAPK9
PTK2
RAF1
RIC8A
SRC
TLR2
TLR4
TLR9
6 interactors:
BTK
HRAS
MAPK8IP3
RNF216
SIGIRR
TLR1
Entrez ID
23162
54106
HPRD ID
12014
05685
Ensembl ID
ENSG00000138834
ENSG00000239732
Uniprot IDs
E9PFH7
Q9UPT6
Q9NR96
PDB IDs
Enriched GO Terms of Interacting Partners
?
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
MyD88-dependent Toll-like Receptor Signaling Pathway
MAPK Cascade
JNK Cascade
Positive Regulation Of Signal Transduction
Regulation Of Protein Kinase Activity
Signal Transduction By Phosphorylation
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Regulation Of Kinase Activity
Toll-like Receptor Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Regulation Of Stress-activated MAPK Cascade
Regulation Of Protein Phosphorylation
Regulation Of MAPK Cascade
Immune Response-regulating Signaling Pathway
Positive Regulation Of Protein Kinase Activity
Intracellular Signal Transduction
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Positive Regulation Of Kinase Activity
Positive Regulation Of Catalytic Activity
Positive Regulation Of Protein Metabolic Process
Activation Of Innate Immune Response
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
Regulation Of Phosphorylation
Positive Regulation Of Transferase Activity
Regulation Of JNK Cascade
Regulation Of Protein Metabolic Process
Innate Immune Response
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of MAP Kinase Activity
Response To Stress
Positive Regulation Of Innate Immune Response
Phosphorylation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Phosphorylation
Regulation Of Phosphorus Metabolic Process
Regulation Of Catalytic Activity
Positive Regulation Of Protein Modification Process
Toll-like Receptor 9 Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of MAP Kinase Activity
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Regulation Of Cytokine Production
Inflammatory Response
Lung Morphogenesis
Regulation Of Immune System Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Defense Response
Immune Response-regulating Signaling Pathway
Toll-like Receptor 1 Signaling Pathway
Regulation Of B Cell Cytokine Production
Regulation Of Cytokine Biosynthetic Process
Toll-like Receptor Signaling Pathway
Response To Stress
Positive Regulation Of JNK Cascade
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Response To External Stimulus
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Cellular Response To Molecule Of Fungal Origin
Detection Of Triacyl Bacterial Lipopeptide
Cellular Response To Triacyl Bacterial Lipopeptide
Activation Of Innate Immune Response
Regulation Of JNK Cascade
Innate Immune Response
Positive Regulation Of Innate Immune Response
Regulation Of Immune Response
Regulation Of Stress-activated MAPK Cascade
Regulation Of Protein Metabolic Process
Response To Molecule Of Fungal Origin
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Rac Protein Signal Transduction
Negative Regulation Of Chemokine Biosynthetic Process
Apoptotic Process
Fc-epsilon Receptor Signaling Pathway
MAPK Cascade
Programmed Cell Death
Positive Regulation Of MiRNA Metabolic Process
Regulation Of Innate Immune Response
Cell Death
Death
Positive Regulation Of Ruffle Assembly
Detection Of Bacterial Lipoprotein
Lung Development
Respiratory Tube Development
Fc Receptor Signaling Pathway
Activation Of Protein Kinase Activity
Positive Regulation Of Protein Serine/threonine Kinase Activity
Signal Transduction By Phosphorylation
Respiratory System Development
Regulation Of MAP Kinase Activity
Tagcloud
?
bed
cd14
constitutively
fibroblast
immunoassay
immunocytochemistry
lamina
lipopolysaccharide
lps
md
measuring
microorganisms
nucleus
p65
polyp
propria
quantified
respond
responsiveness
scar
strategic
supernatant
tlr1
tlr4
tlrs
toll
vff
vffs
vocal
Tagcloud (Difference)
?
bed
cd14
constitutively
fibroblast
immunoassay
immunocytochemistry
lamina
lipopolysaccharide
lps
md
measuring
microorganisms
nucleus
p65
polyp
propria
quantified
respond
responsiveness
scar
strategic
supernatant
tlr1
tlr4
tlrs
toll
vff
vffs
vocal
Tagcloud (Intersection)
?