MAPK8IP3 and TLR9

Number of citations of the paper that reports this interaction (PubMedID 12941697)
53

Data Source:
HPRD (in vivo)

		MAPK8IP3	TLR9
Description		mitogen-activated protein kinase 8 interacting protein 3	toll like receptor 9
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Axon Dendrite Growth Cone Cytoplasmic Vesicle Cell Projection Cell Body Perinuclear Region Of Cytoplasm Axon Cytoplasm	Golgi Membrane Extracellular Region Cytoplasm Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Endosome Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Endolysosome Endolysosome Membrane Phagocytic Vesicle
	Molecular Function	MAP-kinase Scaffold Activity Protein Binding JUN Kinase Binding Kinesin Binding Signaling Receptor Complex Adaptor Activity	Interleukin-1 Receptor Binding SiRNA Binding Pattern Recognition Receptor Activity Protein Homodimerization Activity Unmethylated CpG Binding
	Biological Process	MAPK Cascade Vesicle-mediated Transport Axon Regeneration Negative Regulation Of Apoptotic Process Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Protein Stabilization Axon Development Anterograde Axonal Protein Transport	Microglial Cell Activation Positive Regulation Of Cytokine Production Activation Of Innate Immune Response Toll-like Receptor Signaling Pathway Immune System Process Positive Regulation Of Immunoglobulin Production Regulation Of Dendritic Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Signal Transduction Canonical NF-kappaB Signal Transduction Male Gonad Development Response To Virus Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Maintenance Of Gastrointestinal Epithelium Positive Regulation Of B Cell Proliferation Positive Regulation Of Type I Interferon Production Detection Of Molecule Of Bacterial Origin Positive Regulation Of Chemokine Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Innate Immune Response Regulation Of B Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Regulation Of B Cell Activation Positive Regulation Of B Cell Activation Defense Response To Virus Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Metal Ion Defense Response To Other Organism Endolysosomal Toll-like Receptor Signaling Pathway Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Cellular Response To Chloroquine Positive Regulation Of Intestinal Epithelial Cell Development
Pathways			PI3K Cascade Trafficking and processing of endosomal TLR Toll Like Receptor 9 (TLR9) Cascade Potential therapeutics for SARS TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome
Drugs			Chloroquine Hydroxychloroquine ISS-1018 Golotimod CPG 10101 Tilsotolimod
Diseases
GWAS		Intraocular pressure ( 29617998)	A body shape index ( 34021172) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Colon cancer ( 33632709) Distal colorectal cancer ( 33632709) Feeling nervous ( 29500382) General cognitive ability ( 29844566) Parkinson's disease ( 28892059) Schizophrenia ( 23974872) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		28 interacting genes: ARL4D BTG3 CASP3 FXR1 KLC1 KLC2 LDLRAP1 MAP2K1 MAP2K4 MAP2K7 MAP3K11 MAP3K5 MAPK10 MAPK8 MAPK8IP1 MAPK8IP2 MAPK9 NRIP1 PTK2 RAD51 RAD51D RAF1 RIC8A SRC TLR2 TLR4 TLR9 ZNF575	6 interacting genes: BTK HRAS MAPK8IP3 RNF216 SIGIRR TLR1
Entrez ID		23162	54106
HPRD ID		12014	05685
Ensembl ID		ENSG00000138834	ENSG00000239732
Uniprot IDs		A0A087WYG2 B7ZMF3 E9PFH7 Q9UPT6	Q9NR96
PDB IDs		4PXJ 8PR2 8PR3 8PR4 8PTK	8AR3
Enriched GO Terms of Interacting Partners?		JNK Cascade MAPK Cascade Fc Receptor Signaling Pathway Cellular Senescence Protein Kinase Activity Intracellular Signaling Cassette Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Kinase Activity Positive Regulation Of MAPK Cascade Protein Serine Kinase Activity Regulation Of JNK Cascade JUN Kinase Activity Positive Regulation Of Intracellular Signal Transduction MAP Kinase Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Apoptotic Process Cytoplasm MAP Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Programmed Cell Death Intracellular Signal Transduction Response To Wounding Positive Regulation Of Signal Transduction Regulation Of MAPK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade ATP Binding Nucleotide Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Complex Assembly Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Cellular Response To Oxygen-containing Compound JUN Kinase Binding Kinesin Binding MAP-kinase Scaffold Activity Protein Phosphorylation Detection Of Molecule Of Bacterial Origin Regulation Of Immune Response Protein Tyrosine Kinase Activity Phosphorylation Mitogen-activated Protein Kinase Kinase Kinase Binding Regulation Of Apoptotic Signaling Pathway JUN Kinase Kinase Activity Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Regulation Of Immune System Process Glial Cell Development	Regulation Of Cytokine Production Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Negative Regulation Of Gene Expression Immune Response-regulating Signaling Pathway Cytoplasmic Vesicle Activation Of Immune Response Toll-like Receptor Signaling Pathway Negative Regulation Of Cytokine Production Immune Response-activating Signaling Pathway Positive Regulation Of Type I Hypersensitivity Positive Regulation Of Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Defense Response T Cell Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production B Cell Affinity Maturation Positive Regulation Of JNK Cascade GTPase Complex Detection Of Triacyl Bacterial Lipopeptide Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Negative Regulation Of Toll Signaling Pathway Regulation Of Signal Transduction Response To Stress Positive Regulation Of Immune Response Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Regulation Of Multicellular Organismal Process Positive Regulation Of Signal Transduction Regulation Of Type I Interferon Production Phospholipase C Activator Activity Regulation Of JNK Cascade Cellular Response To Triacyl Bacterial Lipopeptide Antigen Receptor-mediated Signaling Pathway Regulation Of Interleukin-6 Production Positive Regulation Of Synoviocyte Proliferation Pattern Recognition Receptor Signaling Pathway Perinuclear Region Of Cytoplasm Cellular Response To Molecule Of Fungal Origin Toll-like Receptor 2 Binding Detection Of Bacterial Lipoprotein Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Tumor Necrosis Factor Production Innate Immune Response-activating Signaling Pathway Defense Response To Other Organism Regulation Of Cell Communication
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