MAPK8IP3 and MAP3K5

Number of citations of the paper that reports this interaction (PubMedID 12189133)
0

Data Source:
HPRD (in vitro, in vivo)

		MAPK8IP3	MAP3K5
Description		mitogen-activated protein kinase 8 interacting protein 3	mitogen-activated protein kinase kinase kinase 5
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Axon Dendrite Growth Cone Cytoplasmic Vesicle Cell Projection Cell Body Perinuclear Region Of Cytoplasm Axon Cytoplasm	Cytoplasm Endoplasmic Reticulum Cytosol External Side Of Plasma Membrane Protein-containing Complex Protein Kinase Complex IRE1-TRAF2-ASK1 Complex
	Molecular Function	MAP-kinase Scaffold Activity Protein Binding JUN Kinase Binding Kinesin Binding Signaling Receptor Complex Adaptor Activity	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Vesicle-mediated Transport Axon Regeneration Negative Regulation Of Apoptotic Process Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Protein Stabilization Axon Development Anterograde Axonal Protein Transport	MAPK Cascade Immune System Process Response To Ischemia Apoptotic Process JNK Cascade Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Amino Acid Starvation Response To Endoplasmic Reticulum Stress Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress P38MAPK Cascade Positive Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Neuron Apoptotic Process Stress-activated MAPK Cascade Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Hydrogen Peroxide Cellular Response To Tumor Necrosis Factor Endothelial Cell Apoptotic Process Cellular Senescence Apoptotic Signaling Pathway Programmed Necrotic Cell Death Positive Regulation Of P38MAPK Cascade Cellular Response To Reactive Nitrogen Species Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways			Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence
Drugs
Diseases
GWAS		Intraocular pressure ( 29617998)	Eosinophil count ( 32888494) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		28 interacting genes: ARL4D BTG3 CASP3 FXR1 KLC1 KLC2 LDLRAP1 MAP2K1 MAP2K4 MAP2K7 MAP3K11 MAP3K5 MAPK10 MAPK8 MAPK8IP1 MAPK8IP2 MAPK9 NRIP1 PTK2 RAD51 RAD51D RAF1 RIC8A SRC TLR2 TLR4 TLR9 ZNF575	69 interacting genes: AKT1 ARRB2 AURKA BIRC2 CCND2 CDC25A CDC25C CDK4 CDK6 CDKN1A CDKN2A CIB1 CREBBP DAB2IP DAXX DMD DUSP19 EIF2AK2 EP300 ERN1 FGFR4 FZR1 GADD45B GEMIN5 GLIS2 GLRX GSTM1 HSPA1A IGF1R JAK2 MAP2K4 MAP2K6 MAP2K7 MAP3K2 MAP3K3 MAP3K6 MAP3K7 MAPK8IP3 MBP NEDD4 NEDD4L NF2 PDCD6 PPP3R1 PPP5C PRMT1 PTPN11 QARS1 RAF1 SFN SIAH1 STK11 TEAD2 TERT TNFAIP3 TNFAIP8L1 TNNT2 TPD52L1 TRAF2 TRAF5 TRAF6 TULP3 TXN UBE2I USP9X YWHAE YWHAH YWHAQ YWHAZ
Entrez ID		23162	4217
HPRD ID		12014	03904
Ensembl ID		ENSG00000138834	ENSG00000197442
Uniprot IDs		A0A087WYG2 B7ZMF3 E9PFH7 Q9UPT6	A0A8V8TMH5 Q99683
PDB IDs		4PXJ 8PR2 8PR3 8PR4 8PTK	2CLQ 3VW6 4BF2 4BHN 4BIB 4BIC 4BID 4BIE 5ULM 5UOR 5UOX 5UP3 5V19 5V24 5VIL 5VIO 6E2M 6E2N 6E2O 6EJL 6OYT 6OYW 6VRE 6XIH 7MU6 7MU7 8QGY
Enriched GO Terms of Interacting Partners?		JNK Cascade MAPK Cascade Fc Receptor Signaling Pathway Cellular Senescence Protein Kinase Activity Intracellular Signaling Cassette Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Kinase Activity Positive Regulation Of MAPK Cascade Protein Serine Kinase Activity Regulation Of JNK Cascade JUN Kinase Activity Positive Regulation Of Intracellular Signal Transduction MAP Kinase Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Apoptotic Process Cytoplasm MAP Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Programmed Cell Death Intracellular Signal Transduction Response To Wounding Positive Regulation Of Signal Transduction Regulation Of MAPK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade ATP Binding Nucleotide Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Complex Assembly Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Cellular Response To Oxygen-containing Compound JUN Kinase Binding Kinesin Binding MAP-kinase Scaffold Activity Protein Phosphorylation Detection Of Molecule Of Bacterial Origin Regulation Of Immune Response Protein Tyrosine Kinase Activity Phosphorylation Mitogen-activated Protein Kinase Kinase Kinase Binding Regulation Of Apoptotic Signaling Pathway JUN Kinase Kinase Activity Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Regulation Of Immune System Process Glial Cell Development	Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of MAPK Cascade Signal Transduction Cytosol Cytoplasm Positive Regulation Of MAPK Cascade Cellular Response To Stress Regulation Of Protein Metabolic Process MAPK Cascade Regulation Of Programmed Cell Death Regulation Of Protein Modification Process Regulation Of Apoptotic Process Protein Kinase Binding Protein Modification Process Positive Regulation Of Protein Metabolic Process Transferase Activity Enzyme Binding Regulation Of Primary Metabolic Process Protein Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Apoptotic Process Programmed Cell Death Cell Death Positive Regulation Of Metabolic Process Protein Serine Kinase Activity Regulation Of Macromolecule Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Metabolic Process Regulation Of JNK Cascade Kinase Activity Apoptotic Signaling Pathway Protein Serine/threonine Kinase Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Catalytic Activity Identical Protein Binding Negative Regulation Of Signal Transduction Regulation Of Cell Cycle Regulation Of Protein Kinase Activity Protein Metabolic Process Regulation Of Innate Immune Response
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