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MAPK8IP3 and MAP3K5
Number of citations of the paper that reports this interaction (PMID
12189133
)
17
Data Source:
HPRD
(in vitro, in vivo)
MAPK8IP3
MAP3K5
Gene Name
mitogen-activated protein kinase 8 interacting protein 3
mitogen-activated protein kinase kinase kinase 5
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Cytoplasm
Smooth Endoplasmic Reticulum
Dendrite
Axolemma
Endoplasmic Reticulum
Cytosol
Protein Kinase Complex
Molecular Function
MAP-kinase Scaffold Activity
JUN Kinase Binding
Kinesin Binding
Receptor Signaling Complex Scaffold Activity
Mitogen-activated Protein Kinase Kinase Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Magnesium Ion Binding
Protein Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Protein Kinase Binding
Protein Phosphatase Binding
Protein Homodimerization Activity
Biological Process
In Utero Embryonic Development
Activation Of JUN Kinase Activity
Axon Guidance
Respiratory Gaseous Exchange
Protein Localization
Post-embryonic Development
Regulation Of Gene Expression
Vesicle-mediated Transport
Forebrain Development
Positive Regulation Of Neuron Differentiation
Regulation Of JNK Cascade
Lung Alveolus Development
Lung Morphogenesis
MAPK Cascade
Activation Of MAPKK Activity
Response To Ischemia
Protein Phosphorylation
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
JNK Cascade
Activation Of JUN Kinase Activity
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Viral Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Innate Immune Response
Cellular Response To Hydrogen Peroxide
Apoptotic Signaling Pathway
Programmed Necrotic Cell Death
Positive Regulation Of Neuron Death
Cellular Response To Reactive Nitrogen Species
Pathways
Oxidative Stress Induced Senescence
Cellular Senescence
Drugs
Diseases
GWAS
Protein-Protein Interactions
21 interactors:
ARL4D
CASP3
KLC1
KLC2
MAP2K1
MAP2K4
MAP2K7
MAP3K11
MAP3K5
MAPK10
MAPK8
MAPK8IP1
MAPK8IP2
MAPK9
PTK2
RAF1
RIC8A
SRC
TLR2
TLR4
TLR9
50 interactors:
AKT1
AKT2
ARRB1
ARRB2
CDC25A
CDKN1A
CREBBP
DAB2IP
DAXX
DMD
DUSP19
EIF2AK2
EP300
ERN1
GADD45B
GEMIN5
GLRX
GSTM1
HSPA1A
IGF1R
JAK2
MAP2K4
MAP2K6
MAP2K7
MAP3K2
MAP3K3
MAP3K6
MAP3K7
MAPK8IP3
MBP
NEDD4
NEDD4L
PDCD6
PPP3R1
PPP5C
PTPN11
QARS
RAF1
SFN
TNNT2
TPD52L1
TRAF2
TRAF5
TRAF6
TXN
USP9X
YWHAE
YWHAH
YWHAQ
YWHAZ
Entrez ID
23162
4217
HPRD ID
12014
03904
Ensembl ID
ENSG00000138834
ENSG00000197442
Uniprot IDs
E9PFH7
Q9UPT6
Q99683
PDB IDs
2CLQ
3VW6
4BF2
4BHN
4BIB
4BIC
4BID
4BIE
Enriched GO Terms of Interacting Partners
?
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
MyD88-dependent Toll-like Receptor Signaling Pathway
MAPK Cascade
JNK Cascade
Positive Regulation Of Signal Transduction
Regulation Of Protein Kinase Activity
Signal Transduction By Phosphorylation
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Regulation Of Kinase Activity
Toll-like Receptor Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Regulation Of Stress-activated MAPK Cascade
Regulation Of Protein Phosphorylation
Regulation Of MAPK Cascade
Immune Response-regulating Signaling Pathway
Positive Regulation Of Protein Kinase Activity
Intracellular Signal Transduction
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Positive Regulation Of Kinase Activity
Positive Regulation Of Catalytic Activity
Positive Regulation Of Protein Metabolic Process
Activation Of Innate Immune Response
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
Regulation Of Phosphorylation
Positive Regulation Of Transferase Activity
Regulation Of JNK Cascade
Regulation Of Protein Metabolic Process
Innate Immune Response
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of MAP Kinase Activity
Response To Stress
Positive Regulation Of Innate Immune Response
Phosphorylation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Phosphorylation
Regulation Of Phosphorus Metabolic Process
Regulation Of Catalytic Activity
Positive Regulation Of Protein Modification Process
Toll-like Receptor 9 Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of MAP Kinase Activity
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Positive Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Regulation Of Signal Transduction
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Regulation Of Signaling
Positive Regulation Of Protein Kinase Activity
Regulation Of Protein Kinase Activity
Positive Regulation Of Phosphorylation
Positive Regulation Of Kinase Activity
Regulation Of Kinase Activity
Regulation Of Phosphorylation
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of MAPK Cascade
Positive Regulation Of Protein Metabolic Process
Apoptotic Process
Positive Regulation Of Transferase Activity
Programmed Cell Death
Positive Regulation Of Protein Modification Process
Regulation Of Stress-activated MAPK Cascade
Cell Death
Death
Regulation Of MAPK Cascade
Positive Regulation Of Cellular Protein Metabolic Process
Activation Of Protein Kinase Activity
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of JNK Cascade
Response To Stress
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Cell Death
Regulation Of Intracellular Signal Transduction
Regulation Of Catalytic Activity
Regulation Of Apoptotic Process
Cellular Response To Stress
Positive Regulation Of Catalytic Activity
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of JNK Cascade
Positive Regulation Of Metabolic Process
Cellular Response To Stimulus
Response To Stimulus
Intracellular Signal Transduction
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Programmed Cell Death
Signal Transduction
Signaling
Positive Regulation Of Cell Death
Tagcloud
?
199a2
angptl2
awry
chondrosarcoma
cmet
discovering
dnm3
evenly
fibrosarcoma
flt1
flt4
foxl1
genetics
gli1
hif1alpha
hmga2
kdr
liposarcoma
mdk
med12
muc4
mycn
osteocytes
pcsk1
relentless
sarcoma
tek
tie1
yeats4
Tagcloud (Difference)
?
199a2
angptl2
awry
chondrosarcoma
cmet
discovering
dnm3
evenly
fibrosarcoma
flt1
flt4
foxl1
genetics
gli1
hif1alpha
hmga2
kdr
liposarcoma
mdk
med12
muc4
mycn
osteocytes
pcsk1
relentless
sarcoma
tek
tie1
yeats4
Tagcloud (Intersection)
?