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MAPK8IP3 and MAP2K1
Number of citations of the paper that reports this interaction (PMID
10523642
)
44
Data Source:
HPRD
(in vitro)
MAPK8IP3
MAP2K1
Gene Name
mitogen-activated protein kinase 8 interacting protein 3
mitogen-activated protein kinase kinase 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Cytoplasm
Smooth Endoplasmic Reticulum
Dendrite
Axolemma
Nucleus
Cytoplasm
Mitochondrion
Early Endosome
Late Endosome
Endoplasmic Reticulum
Golgi Apparatus
Microtubule Organizing Center
Cytosol
Microtubule
Plasma Membrane
Focal Adhesion
Cell Cortex
Axon
Dendrite Cytoplasm
Perikaryon
Perinuclear Region Of Cytoplasm
Extracellular Vesicular Exosome
Molecular Function
MAP-kinase Scaffold Activity
JUN Kinase Binding
Kinesin Binding
Receptor Signaling Complex Scaffold Activity
Mitogen-activated Protein Kinase Kinase Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
Receptor Signaling Protein Tyrosine Phosphatase Activity
Protein Binding
ATP Binding
Ras GTPase Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Protein Serine/threonine Kinase Activator Activity
Biological Process
In Utero Embryonic Development
Activation Of JUN Kinase Activity
Axon Guidance
Respiratory Gaseous Exchange
Protein Localization
Post-embryonic Development
Regulation Of Gene Expression
Vesicle-mediated Transport
Forebrain Development
Positive Regulation Of Neuron Differentiation
Regulation Of JNK Cascade
Lung Alveolus Development
Lung Morphogenesis
MAPK Cascade
Activation Of MAPKK Activity
Activation Of MAPK Activity
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Regulation Of Vascular Smooth Muscle Contraction
Movement Of Cell Or Subcellular Component
Chemotaxis
Response To Oxidative Stress
Cell Cycle Arrest
Mitotic Nuclear Division
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Small GTPase Mediated Signal Transduction
Ras Protein Signal Transduction
Axon Guidance
Cell Proliferation
Negative Regulation Of Cell Proliferation
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Pathogenesis
Positive Regulation Of Gene Expression
Peptidyl-tyrosine Phosphorylation
Neuron Differentiation
Keratinocyte Differentiation
Positive Regulation Of Cell Migration
Positive Regulation Of Ras GTPase Activity
Melanosome Transport
Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Negative Regulation Of Homotypic Cell-cell Adhesion
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Innate Immune Response
Positive Regulation Of Cell Differentiation
Positive Regulation Of Ras Protein Signal Transduction
Vesicle Transport Along Microtubule
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Golgi Inheritance
Response To Axon Injury
Cell Motility
Protein Heterooligomerization
Response To Glucocorticoid
Stress-activated MAPK Cascade
Placenta Blood Vessel Development
Labyrinthine Layer Development
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Golgi Inheritance
Cellular Senescence
Regulation Of Early Endosome To Late Endosome Transport
Pathways
Signaling by GPCR
Signaling by FGFR in disease
MEK activation
FCERI mediated MAPK activation
Signaling by EGFRvIII in Cancer
Signaling by SCF-KIT
SHC1 events in ERBB2 signaling
Toll Like Receptor TLR1:TLR2 Cascade
DAP12 signaling
Uptake and actions of bacterial toxins
Toll Like Receptor 5 (TLR5) Cascade
Gastrin-CREB signalling pathway via PKC and MAPK
MyD88 dependent cascade initiated on endosome
Toll Like Receptor 9 (TLR9) Cascade
SOS-mediated signalling
Uptake and function of anthrax toxins
SHC-mediated signalling
Signaling by PDGF
DAP12 interactions
TRIF-mediated TLR3/TLR4 signaling
ERK1 activation
SHC-related events triggered by IGF1R
GRB2 events in EGFR signaling
ERK1 activation
Signaling by ERBB4
Toll Like Receptor 2 (TLR2) Cascade
Signaling by ERBB2
Signaling by EGFR
Signaling by Interleukins
SHC1 events in ERBB4 signaling
Signaling by VEGF
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Signalling to RAS
Downstream signal transduction
Fc epsilon receptor (FCERI) signaling
Signaling by EGFR in Cancer
Interleukin-1 signaling
Interleukin-2 signaling
Frs2-mediated activation
Signaling by Leptin
Signalling to ERKs
Prolonged ERK activation events
ERK activation
Axon guidance
IRS-mediated signalling
Toll Like Receptor 7/8 (TLR7/8) Cascade
L1CAM interactions
IGF1R signaling cascade
Toll Like Receptor TLR6:TLR2 Cascade
VEGFA-VEGFR2 Pathway
Activated TLR4 signalling
IRS-related events triggered by IGF1R
MyD88 cascade initiated on plasma membrane
VEGFR2 mediated cell proliferation
GRB2 events in ERBB2 signaling
ERK activation
RAF phosphorylates MEK
Downstream signaling of activated FGFR
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88:Mal cascade initiated on plasma membrane
NCAM signaling for neurite out-growth
RAF/MAP kinase cascade
Signalling to p38 via RIT and RIN
Signaling by Insulin receptor
Innate Immune System
Signalling by NGF
Signal transduction by L1
Insulin receptor signalling cascade
SOS-mediated signalling
MAP kinase activation in TLR cascade
SHC-mediated signalling
Cytokine Signaling in Immune system
IRS-related events
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
SHC-related events
MyD88-independent cascade
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by FGFR
ARMS-mediated activation
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
SHC1 events in EGFR signaling
IRS-mediated signalling
FRS2-mediated cascade
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Drugs
K-252a
5-Bromo-N-(2,3-Dihydroxypropoxy)-3,4-Difluoro-2-[(2-Fluoro-4-Iodophenyl)Amino]Benzamide
Bosutinib
(5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide
2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide
N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine
2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE
Trametinib
Diseases
GWAS
Protein-Protein Interactions
21 interactors:
ARL4D
CASP3
KLC1
KLC2
MAP2K1
MAP2K4
MAP2K7
MAP3K11
MAP3K5
MAPK10
MAPK8
MAPK8IP1
MAPK8IP2
MAPK9
PTK2
RAF1
RIC8A
SRC
TLR2
TLR4
TLR9
41 interactors:
ARAF
BANP
BIRC6
BRAF
CASP9
CDK5
CPNE1
CPNE4
EGFR
ELK1
EP300
GRB10
HNRNPD
HRAS
KSR1
KSR2
LAMTOR3
MAP3K4
MAP3K8
MAPK1
MAPK14
MAPK3
MAPK8
MAPK8IP3
MYC
PAK1
PARVA
PEBP1
PEBP4
PLK3
PPARG
PRKCI
PRKCZ
RAF1
RPS6KA2
RPS6KA4
SUMO1
TRAF3
TRAF6
TRIB1
WNK1
Entrez ID
23162
5604
HPRD ID
12014
01469
Ensembl ID
ENSG00000138834
Uniprot IDs
E9PFH7
Q9UPT6
A4QPA9
B4DFY5
Q02750
PDB IDs
1S9J
2P55
3DV3
3DY7
3E8N
3EQB
3EQC
3EQD
3EQF
3EQG
3EQH
3EQI
3MBL
3ORN
3OS3
3PP1
3SLS
3V01
3V04
3VVH
3ZLS
3ZLW
3ZLX
3ZLY
3ZM4
4AN2
4AN3
4AN9
4ANB
4ARK
Enriched GO Terms of Interacting Partners
?
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
MyD88-dependent Toll-like Receptor Signaling Pathway
MAPK Cascade
JNK Cascade
Positive Regulation Of Signal Transduction
Regulation Of Protein Kinase Activity
Signal Transduction By Phosphorylation
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Regulation Of Kinase Activity
Toll-like Receptor Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Regulation Of Stress-activated MAPK Cascade
Regulation Of Protein Phosphorylation
Regulation Of MAPK Cascade
Immune Response-regulating Signaling Pathway
Positive Regulation Of Protein Kinase Activity
Intracellular Signal Transduction
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Positive Regulation Of Kinase Activity
Positive Regulation Of Catalytic Activity
Positive Regulation Of Protein Metabolic Process
Activation Of Innate Immune Response
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
Regulation Of Phosphorylation
Positive Regulation Of Transferase Activity
Regulation Of JNK Cascade
Regulation Of Protein Metabolic Process
Innate Immune Response
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of MAP Kinase Activity
Response To Stress
Positive Regulation Of Innate Immune Response
Phosphorylation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Phosphorylation
Regulation Of Phosphorus Metabolic Process
Regulation Of Catalytic Activity
Positive Regulation Of Protein Modification Process
Toll-like Receptor 9 Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of MAP Kinase Activity
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Regulation Of Protein Metabolic Process
MAPK Cascade
Signal Transduction By Phosphorylation
Regulation Of Cellular Protein Metabolic Process
Phosphorylation
Intracellular Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Protein Phosphorylation
Regulation Of Phosphorylation
Positive Regulation Of Phosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Regulation Of MAPK Cascade
Regulation Of Phosphorus Metabolic Process
Phosphate-containing Compound Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of MAPK Cascade
Activation Of Protein Kinase Activity
Cellular Response To Organic Substance
Regulation Of Signal Transduction
Response To Organic Substance
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Apoptotic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Programmed Cell Death
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Kinase Activity
Cellular Response To Growth Factor Stimulus
Cell Death
Death
Regulation Of Protein Kinase Activity
Regulation Of Protein Phosphorylation
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Signaling
Response To Growth Factor
Positive Regulation Of Kinase Activity
Signaling
Cellular Protein Modification Process
Regulation Of Kinase Activity
Signal Transduction
Cell Communication
Positive Regulation Of Intracellular Signal Transduction
Innate Immune Response
Regulation Of Catalytic Activity
Positive Regulation Of Transferase Activity
Tagcloud
?
actionable
adenocarcinomas
akt1
alk
braf
capture
ccdc6
cd74
clip4
deemed
driver
fusions
g719a
genomic
introns
kif5b
nccn
ngs
nras
pack
pik3ca
profiling
rearranged
ret
ros1
socs5
targetable
uniform
v600e
Tagcloud (Difference)
?
actionable
adenocarcinomas
akt1
alk
braf
capture
ccdc6
cd74
clip4
deemed
driver
fusions
g719a
genomic
introns
kif5b
nccn
ngs
nras
pack
pik3ca
profiling
rearranged
ret
ros1
socs5
targetable
uniform
v600e
Tagcloud (Intersection)
?