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MAPK8IP3 and MAPK9
Number of citations of the paper that reports this interaction (PMID
10629060
)
49
Data Source:
HPRD
(in vitro, in vivo)
MAPK8IP3
MAPK9
Gene Name
mitogen-activated protein kinase 8 interacting protein 3
mitogen-activated protein kinase 9
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Cytoplasm
Smooth Endoplasmic Reticulum
Dendrite
Axolemma
Nucleoplasm
Mitochondrion
Cytosol
Molecular Function
MAP-kinase Scaffold Activity
JUN Kinase Binding
Kinesin Binding
Receptor Signaling Complex Scaffold Activity
Mitogen-activated Protein Kinase Kinase Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
JUN Kinase Activity
Protein Binding
ATP Binding
Transcription Factor Binding
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Mitogen-activated Protein Kinase Kinase Kinase Binding
Biological Process
In Utero Embryonic Development
Activation Of JUN Kinase Activity
Axon Guidance
Respiratory Gaseous Exchange
Protein Localization
Post-embryonic Development
Regulation Of Gene Expression
Vesicle-mediated Transport
Forebrain Development
Positive Regulation Of Neuron Differentiation
Regulation Of JNK Cascade
Lung Alveolus Development
Lung Morphogenesis
Release Of Cytochrome C From Mitochondria
Positive Regulation Of Protein Phosphorylation
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Protein Phosphorylation
Protein Targeting To Mitochondrion
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Response To Stress
JNK Cascade
JUN Phosphorylation
Central Nervous System Development
Response To Mechanical Stimulus
Response To Toxic Substance
Positive Regulation Of Gene Expression
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Cell Morphogenesis Involved In Differentiation
Response To Amine
Neuron Projection Development
Positive Regulation Of Prostaglandin Biosynthetic Process
Regulation Of Protein Ubiquitination
Positive Regulation Of Prostaglandin Secretion
Positive Regulation Of Chemokine Production
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Cellular Response To UV
TRIF-dependent Toll-like Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Response To Drug
Regulation Of Circadian Rhythm
Innate Immune Response
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Regulation Of JNK Cascade
Response To Cadmium Ion
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Stress-activated MAPK Cascade
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Cellular Response To Lipopolysaccharide
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Apoptotic Signaling Pathway
Pathways
Toll Like Receptor 7/8 (TLR7/8) Cascade
Cellular Senescence
FCERI mediated MAPK activation
Toll Like Receptor TLR6:TLR2 Cascade
Activated TLR4 signalling
Toll Like Receptor TLR1:TLR2 Cascade
Activation of the AP-1 family of transcription factors
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
MyD88 dependent cascade initiated on endosome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88:Mal cascade initiated on plasma membrane
Toll Like Receptor 9 (TLR9) Cascade
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Innate Immune System
TRIF-mediated TLR3/TLR4 signaling
MAP kinase activation in TLR cascade
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Oxidative Stress Induced Senescence
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Fc epsilon receptor (FCERI) signaling
MAPK targets/ Nuclear events mediated by MAP kinases
Drugs
Diseases
GWAS
Protein-Protein Interactions
21 interactors:
ARL4D
CASP3
KLC1
KLC2
MAP2K1
MAP2K4
MAP2K7
MAP3K11
MAP3K5
MAPK10
MAPK8
MAPK8IP1
MAPK8IP2
MAPK9
PTK2
RAF1
RIC8A
SRC
TLR2
TLR4
TLR9
70 interactors:
ACP5
ARRB1
ARRB2
ATF2
ATF7
BAZ1B
BCL2L11
C1orf94
CASP3
CCDC33
CDC25B
CDC25C
CEP44
CLU
CTBP1
CTNNB1
CYHR1
DUSP16
DUSP19
DUSP4
EEF2K
EFHC2
ELK1
ELK3
GRB2
H3F3A
HDAC9
HSF1
IRS1
JDP2
JUN
JUNB
JUND
KIAA1377
L3MBTL3
LMAN2
LNX1
MACF1
MAP2K4
MAP2K7
MAP3K1
MAP3K10
MAPK8IP1
MAPK8IP2
MAPK8IP3
MAPKAPK5
MAPKBP1
MEOX1
NCF1
NFATC3
NFATC4
PRKD1
RB1
RPS6KB1
SF3B4
SH3BP5
SHMT1
SMAD2
SMAD3
SMCO3
SSU72
TEX11
TOB1
TP53
TRAF2
TUSC2
WDR62
XPNPEP1
XPO7
ZBTB25
Entrez ID
23162
5601
HPRD ID
12014
04206
Ensembl ID
ENSG00000138834
ENSG00000050748
Uniprot IDs
E9PFH7
Q9UPT6
P45984
PDB IDs
3E7O
3NPC
Enriched GO Terms of Interacting Partners
?
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
MyD88-dependent Toll-like Receptor Signaling Pathway
MAPK Cascade
JNK Cascade
Positive Regulation Of Signal Transduction
Regulation Of Protein Kinase Activity
Signal Transduction By Phosphorylation
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Regulation Of Kinase Activity
Toll-like Receptor Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Regulation Of Stress-activated MAPK Cascade
Regulation Of Protein Phosphorylation
Regulation Of MAPK Cascade
Immune Response-regulating Signaling Pathway
Positive Regulation Of Protein Kinase Activity
Intracellular Signal Transduction
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Positive Regulation Of Kinase Activity
Positive Regulation Of Catalytic Activity
Positive Regulation Of Protein Metabolic Process
Activation Of Innate Immune Response
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
Regulation Of Phosphorylation
Positive Regulation Of Transferase Activity
Regulation Of JNK Cascade
Regulation Of Protein Metabolic Process
Innate Immune Response
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of MAP Kinase Activity
Response To Stress
Positive Regulation Of Innate Immune Response
Phosphorylation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Phosphorylation
Regulation Of Phosphorus Metabolic Process
Regulation Of Catalytic Activity
Positive Regulation Of Protein Modification Process
Toll-like Receptor 9 Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of MAP Kinase Activity
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
Regulation Of Phosphorylation
Positive Regulation Of Metabolic Process
Regulation Of Protein Phosphorylation
Regulation Of Metabolic Process
Regulation Of Phosphorus Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Response To Stress
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Signal Transduction
Positive Regulation Of Protein Metabolic Process
MAPK Cascade
Intracellular Signal Transduction
Regulation Of Kinase Activity
Apoptotic Process
Regulation Of Protein Kinase Activity
Signal Transduction By Phosphorylation
Negative Regulation Of Cellular Metabolic Process
Programmed Cell Death
Cell Death
Death
Regulation Of Signal Transduction
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Regulation Of MAPK Cascade
Positive Regulation Of Cellular Biosynthetic Process
Developmental Process
Regulation Of Cellular Process
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Neuron Death
Positive Regulation Of Protein Modification Process
Positive Regulation Of Macromolecule Biosynthetic Process
Defense Response
Cellular Metabolic Process
Cellular Response To Stress
Regulation Of Signaling
Regulation Of Gene Expression
Anatomical Structure Development
Cell Differentiation
Positive Regulation Of Phosphorylation
Signal Transduction
Toll-like Receptor 4 Signaling Pathway
Immune System Process
Transcription From RNA Polymerase II Promoter
Regulation Of Catalytic Activity
Regulation Of JUN Kinase Activity
Signaling
Tagcloud
?
abeta1
autophagic
autophagosomes
autophagy
bcl2
beclin
becn1
buildup
digested
elevation
favor
favoring
flux
hamper
incompletely
jnk1
jnk2
lc3
lysosomal
mapk8
modifying
monomers
neuroblastoma
oligomers
phosphorylating
profound
sk
turn
vacuoles
Tagcloud (Difference)
?
abeta1
autophagic
autophagosomes
autophagy
bcl2
beclin
becn1
buildup
digested
elevation
favor
favoring
flux
hamper
incompletely
jnk1
jnk2
lc3
lysosomal
mapk8
modifying
monomers
neuroblastoma
oligomers
phosphorylating
profound
sk
turn
vacuoles
Tagcloud (Intersection)
?