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MAPK8IP3 and TLR2
Number of citations of the paper that reports this interaction (PMID
12941697
)
17
Data Source:
HPRD
(in vivo)
MAPK8IP3
TLR2
Gene Name
mitogen-activated protein kinase 8 interacting protein 3
toll-like receptor 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Cytoplasm
Smooth Endoplasmic Reticulum
Dendrite
Axolemma
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex
Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex
Cell Projection
Cell Body
Molecular Function
MAP-kinase Scaffold Activity
JUN Kinase Binding
Kinesin Binding
Receptor Signaling Complex Scaffold Activity
Mitogen-activated Protein Kinase Kinase Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Lipopolysaccharide Receptor Activity
Receptor Activity
Transmembrane Signaling Receptor Activity
Protein Binding
Signaling Pattern Recognition Receptor Activity
Triacyl Lipopeptide Binding
Diacyl Lipopeptide Binding
Peptidoglycan Binding
Protein Heterodimerization Activity
Lipoteichoic Acid Binding
Biological Process
In Utero Embryonic Development
Activation Of JUN Kinase Activity
Axon Guidance
Respiratory Gaseous Exchange
Protein Localization
Post-embryonic Development
Regulation Of Gene Expression
Vesicle-mediated Transport
Forebrain Development
Positive Regulation Of Neuron Differentiation
Regulation Of JNK Cascade
Lung Alveolus Development
Lung Morphogenesis
Response To Hypoxia
Microglial Cell Activation
Toll-like Receptor Signaling Pathway
Response To Molecule Of Fungal Origin
Positive Regulation Of Leukocyte Migration
Cell Surface Pattern Recognition Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Leukotriene Metabolic Process
Apoptotic Process
Inflammatory Response
Immune Response
Signal Transduction
I-kappaB Phosphorylation
Negative Regulation Of Cell Proliferation
Response To Toxic Substance
Positive Regulation Of Wnt Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Central Nervous System Myelin Formation
Response To Progesterone
Negative Regulation Of Interleukin-12 Production
Negative Regulation Of Interleukin-17 Production
Positive Regulation Of Chemokine Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-18 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Response To Insulin
Positive Regulation Of Toll-like Receptor Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Positive Regulation Of NF-kappaB Import Into Nucleus
Detection Of Triacyl Bacterial Lipopeptide
Detection Of Diacyl Bacterial Lipopeptide
Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process
Chloramphenicol Transport
Negative Regulation Of Growth Of Symbiont In Host
Innate Immune Response
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Nitric Oxide Metabolic Process
Positive Regulation Of Oligodendrocyte Differentiation
Positive Regulation Of Cytokine Secretion
Positive Regulation Of Inflammatory Response
Defense Response To Gram-positive Bacterium
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Induction By Symbiont Of Defense-related Host Nitric Oxide Production
Positive Regulation Of Macrophage Cytokine Production
Response To Fatty Acid
Cellular Response To Bacterial Lipopeptide
Cellular Response To Lipoteichoic Acid
Cellular Response To Peptidoglycan
Cellular Response To Diacyl Bacterial Lipopeptide
Cellular Response To Triacyl Bacterial Lipopeptide
Pathways
Toll Like Receptor 2 (TLR2) Cascade
Activated TLR4 signalling
Toll Like Receptor TLR1:TLR2 Cascade
Toll-Like Receptors Cascades
Toll Like Receptor 4 (TLR4) Cascade
Beta defensins
MyD88:Mal cascade initiated on plasma membrane
Defensins
Toll Like Receptor TLR6:TLR2 Cascade
Innate Immune System
Drugs
OspA lipoprotein
S-(Dimethylarsenic)Cysteine
Diseases
GWAS
Protein-Protein Interactions
21 interactors:
ARL4D
CASP3
KLC1
KLC2
MAP2K1
MAP2K4
MAP2K7
MAP3K11
MAP3K5
MAPK10
MAPK8
MAPK8IP1
MAPK8IP2
MAPK9
PTK2
RAF1
RIC8A
SRC
TLR2
TLR4
TLR9
18 interactors:
CD14
HMGB1
HRAS
HSP90B1
IRAK1
LY96
MAPK8IP3
MYD88
PIK3R1
RAC1
RIPK2
TICAM1
TIRAP
TLR1
TLR10
TLR6
TOLLIP
TRIP6
Entrez ID
23162
7097
HPRD ID
12014
04323
Ensembl ID
ENSG00000138834
Uniprot IDs
E9PFH7
Q9UPT6
B3KWR9
O60603
PDB IDs
1FYW
1FYX
1O77
2Z7X
2Z80
Enriched GO Terms of Interacting Partners
?
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
MyD88-dependent Toll-like Receptor Signaling Pathway
MAPK Cascade
JNK Cascade
Positive Regulation Of Signal Transduction
Regulation Of Protein Kinase Activity
Signal Transduction By Phosphorylation
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Regulation Of Kinase Activity
Toll-like Receptor Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Regulation Of Stress-activated MAPK Cascade
Regulation Of Protein Phosphorylation
Regulation Of MAPK Cascade
Immune Response-regulating Signaling Pathway
Positive Regulation Of Protein Kinase Activity
Intracellular Signal Transduction
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Positive Regulation Of Kinase Activity
Positive Regulation Of Catalytic Activity
Positive Regulation Of Protein Metabolic Process
Activation Of Innate Immune Response
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
Regulation Of Phosphorylation
Positive Regulation Of Transferase Activity
Regulation Of JNK Cascade
Regulation Of Protein Metabolic Process
Innate Immune Response
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of MAP Kinase Activity
Response To Stress
Positive Regulation Of Innate Immune Response
Phosphorylation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Phosphorylation
Regulation Of Phosphorus Metabolic Process
Regulation Of Catalytic Activity
Positive Regulation Of Protein Modification Process
Toll-like Receptor 9 Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of MAP Kinase Activity
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor Signaling Pathway
Innate Immune Response
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Immune Response-regulating Signaling Pathway
Activation Of Innate Immune Response
Positive Regulation Of Innate Immune Response
MyD88-dependent Toll-like Receptor Signaling Pathway
Immune Response
Defense Response
Regulation Of Innate Immune Response
Inflammatory Response
Regulation Of Immune Response
Positive Regulation Of Immune Response
Toll-like Receptor 4 Signaling Pathway
Cellular Response To Molecule Of Bacterial Origin
Positive Regulation Of Immune System Process
Immune System Process
Positive Regulation Of Tumor Necrosis Factor Production
Regulation Of Immune System Process
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Response To Stress
Positive Regulation Of Protein Metabolic Process
Regulation Of Tumor Necrosis Factor Production
Response To Molecule Of Bacterial Origin
Intracellular Signal Transduction
Regulation Of Cytokine Production
I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Signal Transduction
Response To External Stimulus
Response To Bacterium
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Interleukin-6 Production
Positive Regulation Of Cytokine Production
Lipopolysaccharide-mediated Signaling Pathway
Signal Transduction
Cellular Response To Stimulus
Regulation Of Protein Metabolic Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of JNK Cascade
Signaling
Cell Communication
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Response To Other Organism
Tagcloud
?
1racp
abilities
analysed
ankylosing
asdas
basdai
basfi
bath
besides
box
chromosomal
compare
correlations
crp
elisa
erythrocytesedimentationrate
esr
from71
healthy
hmgb1
index
mobility
pbmcs
rage
remarkably
spondylitis
surface
tlr4
untreated
Tagcloud (Difference)
?
1racp
abilities
analysed
ankylosing
asdas
basdai
basfi
bath
besides
box
chromosomal
compare
correlations
crp
elisa
erythrocytesedimentationrate
esr
from71
healthy
hmgb1
index
mobility
pbmcs
rage
remarkably
spondylitis
surface
tlr4
untreated
Tagcloud (Intersection)
?