MAPK8IP3 and TLR2

Number of citations of the paper that reports this interaction (PubMedID 12941697)
53

Data Source:
HPRD (in vivo)

		MAPK8IP3	TLR2
Description		mitogen-activated protein kinase 8 interacting protein 3	toll like receptor 2
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Axon Dendrite Growth Cone Cytoplasmic Vesicle Cell Projection Cell Body Perinuclear Region Of Cytoplasm Axon Cytoplasm	Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex Receptor Complex Membrane Raft
	Molecular Function	MAP-kinase Scaffold Activity Protein Binding JUN Kinase Binding Kinesin Binding Signaling Receptor Complex Adaptor Activity	Lipopolysaccharide Binding Amyloid-beta Binding Lipopolysaccharide Immune Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Toll-like Receptor Binding Signaling Receptor Activity Pattern Recognition Receptor Activity Triacyl Lipopeptide Binding Identical Protein Binding Peptidoglycan Binding Protein-containing Complex Binding NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
	Biological Process	MAPK Cascade Vesicle-mediated Transport Axon Regeneration Negative Regulation Of Apoptotic Process Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Protein Stabilization Axon Development Anterograde Axonal Protein Transport	Toll-like Receptor Signaling Pathway Immune System Process Apoptotic Process Inflammatory Response Immune Response Signal Transduction Learning Positive Regulation Of Gene Expression Microglia Development Positive Regulation Of Wnt Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Detection Of Triacyl Bacterial Lipopeptide Detection Of Diacyl Bacterial Lipopeptide Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Negative Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Negative Regulation Of Synapse Assembly Cellular Response To Bacterial Lipopeptide Cellular Response To Lipoteichoic Acid Cellular Response To Type II Interferon Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Matrix Metallopeptidase Secretion
Pathways			ER-Phagosome pathway Beta defensins MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor TLR6:TLR2 Cascade MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Neutrophil degranulation Modulation by Mtb of host immune system SARS-CoV-2 activates/modulates innate and adaptive immune responses RSV-host interactions
Drugs			Lyme disease vaccine (recombinant OspA) Adapalene S-(Dimethylarsenic)Cysteine Golotimod Tuberculin purified protein derivative Pam2csk4
Diseases
GWAS		Intraocular pressure ( 29617998)	Body fat mass ( 28552196)
Interacting Genes		28 interacting genes: ARL4D BTG3 CASP3 FXR1 KLC1 KLC2 LDLRAP1 MAP2K1 MAP2K4 MAP2K7 MAP3K11 MAP3K5 MAPK10 MAPK8 MAPK8IP1 MAPK8IP2 MAPK9 NRIP1 PTK2 RAD51 RAD51D RAF1 RIC8A SRC TLR2 TLR4 TLR9 ZNF575	29 interacting genes: AKT1 ANP32B CD14 EGFR FBP1 HEMGN HMGB1 HRAS HSP90B1 IRAK1 LY96 MAP2K1 MAPK8IP3 MYD88 NANS PIK3R1 RAC1 RIPK2 SMAD1 STX17 TGFB1 TICAM1 TIRAP TLR1 TLR10 TLR6 TMOD1 TOLLIP TRIP6
Entrez ID		23162	7097
HPRD ID		12014	04323
Ensembl ID		ENSG00000138834	ENSG00000137462
Uniprot IDs		A0A087WYG2 B7ZMF3 E9PFH7 Q9UPT6	A0A0S2Z4S4 B3KWR9 O60603
PDB IDs		4PXJ 8PR2 8PR3 8PR4 8PTK	1FYW 1FYX 1O77 2Z7X 2Z80 6NIG 8AR0
Enriched GO Terms of Interacting Partners?		JNK Cascade MAPK Cascade Fc Receptor Signaling Pathway Cellular Senescence Protein Kinase Activity Intracellular Signaling Cassette Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Kinase Activity Positive Regulation Of MAPK Cascade Protein Serine Kinase Activity Regulation Of JNK Cascade JUN Kinase Activity Positive Regulation Of Intracellular Signal Transduction MAP Kinase Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Apoptotic Process Cytoplasm MAP Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Programmed Cell Death Intracellular Signal Transduction Response To Wounding Positive Regulation Of Signal Transduction Regulation Of MAPK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade ATP Binding Nucleotide Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Complex Assembly Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Cellular Response To Oxygen-containing Compound JUN Kinase Binding Kinesin Binding MAP-kinase Scaffold Activity Protein Phosphorylation Detection Of Molecule Of Bacterial Origin Regulation Of Immune Response Protein Tyrosine Kinase Activity Phosphorylation Mitogen-activated Protein Kinase Kinase Kinase Binding Regulation Of Apoptotic Signaling Pathway JUN Kinase Kinase Activity Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Regulation Of Immune System Process Glial Cell Development	Regulation Of Innate Immune Response Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Inflammatory Response Positive Regulation Of Innate Immune Response Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 4 Signaling Pathway Regulation Of Tumor Necrosis Factor Production Innate Immune Response-activating Signaling Pathway Positive Regulation Of Defense Response Cell Surface Toll-like Receptor Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Activation Of Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Response To Molecule Of Bacterial Origin Defense Response Immune Response-activating Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Positive Regulation Of Cytokine Production Regulation Of Defense Response Immune Response-regulating Signaling Pathway Cellular Response To Oxygen-containing Compound Positive Regulation Of Interleukin-6 Production Positive Regulation Of Intracellular Signal Transduction Defense Response To Other Organism Cellular Response To Bacterial Lipopeptide Toll-like Receptor 2 Binding Response To Lipid Response To Bacterial Lipoprotein Positive Regulation Of Gene Expression Innate Immune Response Regulation Of Cytokine Production Response To Stress Response To External Biotic Stimulus Regulation Of Immune System Process Response To Other Organism Defense Response To Symbiont Cellular Response To Lipid Immune Response Regulation Of Interleukin-6 Production Regulation Of Signal Transduction
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