AMBRA1 and RNF2

Number of citations of the paper that reports this interaction (PMID 24980959)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology, pull down, enzymatic study)

		AMBRA1	RNF2
Gene Name		autophagy/beclin-1 regulator 1	ring finger protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Autophagic Vacuole Cytosol Axoneme Intracellular Membrane-bounded Organelle Phagocytic Vesicle	Ubiquitin Ligase Complex Euchromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex MLL1 Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity RING-like Zinc Finger Domain Binding
	Biological Process	Autophagy Negative Regulation Of Cell Proliferation Neural Tube Development Cell Differentiation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Mitochondrion Degradation Regulation Of Autophagic Vacuole Assembly	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Gastrulation With Mouth Forming Second Transcription, DNA-templated Anterior/posterior Axis Specification Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination
Pathways			Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS		Immunoglobulin A ( 20694011)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		5 interactors: BECN1 DYNLL1 MTOR RNF2 UBE2D3	54 interactors: ABCB1 AMBRA1 BMI1 CASP3 CASP9 CBX4 CBX6 CBX7 CBX8 HIST1H2AB HIST2H2AA3 HIST2H2AC HIST3H3 KAT8 KMT2A L3MBTL2 MBD1 OTUD6A PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 PGP PHB2 PHC1 PSMC4 RING1 RRM1 RYBP SMURF2 SSX2 TARDBP TFCP2 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2J1 UBE2K UBE2L3 UBE2U UBE2V1 UBE2V2 UBE2W UBE3A USP11 USP19 USP7 WASH1
Entrez ID		55626	6045
HPRD ID		10975	07028
Ensembl ID		ENSG00000110497	ENSG00000121481
Uniprot IDs		Q9C0C7	B3KRH1 Q99496
PDB IDs			2H0D 3GS2 3H8H 3IXS 3RPG
Enriched GO Terms of Interacting Partners?		Response To Hypoxia Protein Monoubiquitination Positive Regulation Of Organelle Organization Positive Regulation Of Mitochondrion Organization Cellular Response To Growth Factor Stimulus Regulation Of Mitochondrion Organization Response To Growth Factor Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Autophagy Cellular Response To Aluminum Ion Regulation Of Carbohydrate Utilization Cellular Response To Oxygen Levels Negative Regulation Of Cellular Metabolic Process Immune System Process Positive Regulation Of Mitochondrion Degradation CVT Pathway Histone H2A-K119 Monoubiquitination Cellular Nitrogen Compound Metabolic Process Regulation Of Organelle Organization Cellular Response To Nutrient Levels Nitrogen Compound Metabolic Process Cellular Response To Extracellular Stimulus Response To Nutrient Response To Abiotic Stimulus Response To Aluminum Ion Late Endosome To Vacuole Transport Negative Regulation Of NFAT Protein Import Into Nucleus Defense Response Cell Cycle Positive Regulation Of Transcription From RNA Polymerase III Promoter Regulation Of Mitochondrion Degradation Histone H2A Monoubiquitination Cellular Response To Stress Negative Regulation Of Macroautophagy Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Macroautophagy Histone H2A Ubiquitination Response To Nutrient Levels Negative Regulation Of Cell Size Regulation Of Metabolic Process Regulation Of Intracellular Transport Regulation Of Fatty Acid Beta-oxidation Cellular Response To Nitrogen Starvation Positive Regulation Of Lamellipodium Organization Response To Extracellular Stimulus Regulation Of Response To Food Immune Response-regulating Signaling Pathway Catabolic Process Response To Vitamin E	Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Protein K48-linked Ubiquitination Cellular Protein Modification Process Histone Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Protein Catabolic Process Chromatin Modification Cellular Macromolecule Catabolic Process Protein Catabolic Process Cellular Metabolic Process Chromatin Organization Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Transcription, DNA-templated Chromosome Organization Histone Modification RNA Biosynthetic Process Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Proteolysis Protein Monoubiquitination Negative Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Catabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Protein K63-linked Ubiquitination Macromolecule Biosynthetic Process Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Gene Expression Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression
Tagcloud ?		aldrich arp2 associates autophagy becn1 cul4a ddb1 e3 elusive endosomal impairs impede interactor k48 k63 ligase linkage pik3c3 potentiates rnf2 scar sorting starvation suppresses ubiquitinate ubiquitination wash wasp wiskott	aldrich ambra1 arp2 associates autophagy becn1 cul4a ddb1 e3 elusive endosomal impairs impede interactor k48 k63 ligase linkage pik3c3 potentiates scar sorting starvation suppresses ubiquitinate ubiquitination wash wasp wiskott
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		aldrich ambra1 arp2 associates autophagy becn1 cul4a ddb1 e3 elusive endosomal impairs impede interactor k48 k63 ligase linkage pik3c3 potentiates rnf2 scar sorting starvation suppresses ubiquitinate ubiquitination wash wasp wiskott