AMBRA1 and BECN1

Number of citations of the paper that reports this interaction (PMID 17589504)
154

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		AMBRA1	BECN1
Gene Name		autophagy/beclin-1 regulator 1	beclin 1, autophagy related
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Autophagic Vacuole Cytosol Axoneme Intracellular Membrane-bounded Organelle Phagocytic Vesicle	Pre-autophagosomal Structure Nucleus Trans-Golgi Network Cytoplasmic Membrane-bounded Vesicle Extrinsic Component Of Membrane Dendrite Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phagocytic Vesicle
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Protein Binding
	Biological Process	Autophagy Negative Regulation Of Cell Proliferation Neural Tube Development Cell Differentiation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Mitochondrion Degradation Regulation Of Autophagic Vacuole Assembly	Autophagic Vacuole Assembly Cytokinesis Response To Hypoxia Cellular Defense Response Cellular Response To Nitrogen Starvation Lysosome Organization Negative Regulation Of Cell Proliferation Positive Regulation Of Autophagy Viral Process Positive Regulation Of Macroautophagy CVT Pathway Response To Vitamin E Response To Drug Negative Regulation Of Apoptotic Process Nucleophagy Late Endosome To Vacuole Transport Neuron Development Beta-amyloid Metabolic Process Regulation Of Catalytic Activity Defense Response To Virus Cellular Response To Aluminum Ion Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Mitochondrion Degradation
Pathways
Drugs
Diseases
GWAS		Immunoglobulin A ( 20694011)
Protein-Protein Interactions		5 interactors: BECN1 DYNLL1 MTOR RNF2 UBE2D3	15 interactors: AMBRA1 ATG14 ATG3 BCL2 BCL2L1 CASP3 CDKN2A GFI1B GOPC ITCH NEDD4 PIK3R4 TRAF6 WASH1 XPO1
Entrez ID		55626	8678
HPRD ID		10975	05087
Ensembl ID		ENSG00000110497	ENSG00000126581
Uniprot IDs		Q9C0C7	E7EV84 Q14457
PDB IDs			2P1L 2PON 3DVU 4DDP
Enriched GO Terms of Interacting Partners?		Response To Hypoxia Protein Monoubiquitination Positive Regulation Of Organelle Organization Positive Regulation Of Mitochondrion Organization Cellular Response To Growth Factor Stimulus Regulation Of Mitochondrion Organization Response To Growth Factor Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Autophagy Cellular Response To Aluminum Ion Regulation Of Carbohydrate Utilization Cellular Response To Oxygen Levels Negative Regulation Of Cellular Metabolic Process Immune System Process Positive Regulation Of Mitochondrion Degradation CVT Pathway Histone H2A-K119 Monoubiquitination Cellular Nitrogen Compound Metabolic Process Regulation Of Organelle Organization Cellular Response To Nutrient Levels Nitrogen Compound Metabolic Process Cellular Response To Extracellular Stimulus Response To Nutrient Response To Abiotic Stimulus Response To Aluminum Ion Late Endosome To Vacuole Transport Negative Regulation Of NFAT Protein Import Into Nucleus Defense Response Cell Cycle Positive Regulation Of Transcription From RNA Polymerase III Promoter Regulation Of Mitochondrion Degradation Histone H2A Monoubiquitination Cellular Response To Stress Negative Regulation Of Macroautophagy Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Macroautophagy Histone H2A Ubiquitination Response To Nutrient Levels Negative Regulation Of Cell Size Regulation Of Metabolic Process Regulation Of Intracellular Transport Regulation Of Fatty Acid Beta-oxidation Cellular Response To Nitrogen Starvation Positive Regulation Of Lamellipodium Organization Response To Extracellular Stimulus Regulation Of Response To Food Immune Response-regulating Signaling Pathway Catabolic Process Response To Vitamin E	Regulation Of Cellular Component Organization Apoptotic Mitochondrial Changes Protein K63-linked Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Polyubiquitination Cellular Response To Stress Intracellular Transport Intracellular Receptor Signaling Pathway Regulation Of Execution Phase Of Apoptosis Regulation Of Autophagy Regulation Of Organelle Organization Release Of Cytochrome C From Mitochondria Establishment Of Localization In Cell Protein Ubiquitination Apoptotic Process Negative Regulation Of Cellular Metabolic Process Programmed Cell Death Protein Modification By Small Protein Conjugation Regulation Of Cellular Localization Cellular Response To Starvation Cell Death Death Regulation Of T Cell Proliferation Regulation Of Establishment Of Protein Localization Organelle Organization Autophagy Mitochondrion Organization Regulation Of Lymphocyte Activation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Localization Cellular Response To Nutrient Levels Response To Starvation Regulation Of Protein Localization Regulation Of Intracellular Transport Neuron Apoptotic Process Macroautophagy Response To Stress Regulation Of B Cell Proliferation Regulation Of Cell Activation Neuron Death Cellular Response To Extracellular Stimulus Negative Regulation Of T Cell Proliferation Regulation Of Apoptotic DNA Fragmentation Negative Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Regulation Of Apoptotic Process Negative Regulation Of Leukocyte Proliferation
Tagcloud ?		aldrich arp2 associates autophagy becn1 cul4a ddb1 e3 elusive endosomal impairs impede interactor k48 k63 ligase linkage pik3c3 potentiates rnf2 scar sorting starvation suppresses ubiquitinate ubiquitination wash wasp wiskott	antiretroviral antiviral ascribed assemble atg8 autophagic autophagy cargo constitutes defines destruction establishes exemplified explains hitherto machinery nucleate platforms preparation recognizes regulators reminiscent restriction trim trim5 trim5alpha trims tripartite ulk1
Tagcloud (Difference) ?		aldrich arp2 associates cul4a ddb1 e3 elusive endosomal impairs impede interactor k48 k63 ligase linkage pik3c3 potentiates rnf2 scar sorting starvation suppresses ubiquitinate ubiquitination wash wasp wiskott	antiretroviral antiviral ascribed assemble atg8 autophagic cargo constitutes defines destruction establishes exemplified explains hitherto machinery nucleate platforms preparation recognizes regulators reminiscent restriction trim trim5 trim5alpha trims tripartite ulk1
Tagcloud (Intersection) ?		autophagy becn1