RET and GAB1

Number of citations of the paper that reports this interaction (PMID 11360177)
13

Data Source:
HPRD (in vivo)

		RET	GAB1
Gene Name		ret proto-oncogene	GRB2-associated binding protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Intracellular Membrane-bounded Organelle Receptor Complex Membrane Raft	Cytosol
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Activity Calcium Ion Binding Protein Binding ATP Binding	Signal Transducer Activity SH3/SH2 Adaptor Activity Protein Binding
	Biological Process	MAPK Cascade Ureteric Bud Development Neural Crest Cell Migration Embryonic Epithelial Tube Formation Protein Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Neuron Cell-cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Posterior Midgut Development Positive Regulation Of Neuron Projection Development Positive Regulation Of Neuron Maturation Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Membrane Protein Proteolysis Positive Regulation Of Cell Adhesion Mediated By Integrin Ureter Maturation Response To Drug Neuron Maturation Positive Regulation Of Cell Size Positive Regulation Of Transcription, DNA-templated Response To Pain Enteric Nervous System Development Regulation Of Axonogenesis Retina Development In Camera-type Eye Innervation Peyer's Patch Morphogenesis Cellular Response To Retinoic Acid Positive Regulation Of Metanephric Glomerulus Development Lymphocyte Migration Into Lymphoid Organs Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Response To Oxidative Stress Epidermal Growth Factor Receptor Signaling Pathway Activation Of JUN Kinase Activity Heart Development Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Regulation Of Cell Migration Fc-epsilon Receptor Signaling Pathway Innate Immune Response Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Labyrinthine Layer Development Interleukin-6-mediated Signaling Pathway
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling IRS-mediated signalling IGF1R signaling cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling IRS-related events triggered by IGF1R PI3K/AKT activation Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR PI3K Cascade Innate Immune System Signaling by Insulin receptor Signaling by PDGF Signalling by NGF DAP12 interactions Insulin receptor signalling cascade GAB1 signalosome IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR IRS-mediated signalling Downstream signal transduction Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Signaling by FGFR mutants PI3K/AKT Signaling in Cancer Constitutive Signaling by EGFRvIII PI3K Cascade Adaptive Immune System
Drugs		Imatinib
Diseases
GWAS		Hirschsprung's disease ( 19196962)	Asthma ( 21804548)
Protein-Protein Interactions		36 interactors: AKAP5 CBL CBLB CRK DOK1 DOK2 DOK3 DOK4 DOK5 DOK6 FRS2 GAB1 GDNF GFRA1 GRB10 GRB2 GRB7 IKBKG MAPK1 MAPK14 MAPK3 MAPK8 NOTCH2NL NOTCH3 NRTN PDLIM7 PIK3R1 PLCG1 PRKAR2A PTK2 PTPN11 PTPRF SHC1 SHC3 SRC STAT3	31 interactors: ARHGAP32 C1QBP CRK CRKL EGFR EPOR FRS2 GAB2 GRAP2 GRB2 GTF2A1L INPP5D INSR LAT2 MAP3K3 MAPK1 MAPK3 MAPK4 MARK2 MET MST1R PDGFRB PIK3CG PIK3R1 PLCG1 PLCG2 PTPN11 PTPN18 RET SHC1 SOS1
Entrez ID		5979	2549
HPRD ID		01266	05116
Ensembl ID		ENSG00000165731	ENSG00000109458
Uniprot IDs		P07949 Q9BTX6	Q13480 Q9HA84
PDB IDs		1XPD 2IVS 2IVT 2IVU 2IVV 2X2K 2X2L 2X2M 2X2U
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Signaling Cellular Response To Growth Factor Stimulus Cell Communication Response To Growth Factor Response To Peptide Response To Peptide Hormone Fc Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Positive Regulation Of Signal Transduction Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Cellular Response To Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cellular Response To Hormone Stimulus Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Insulin Response To Organonitrogen Compound Blood Coagulation Hemostasis Activation Of Protein Kinase Activity Cellular Response To Organic Substance Response To Stimulus Innate Immune Response Fc-epsilon Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Signaling Positive Regulation Of Protein Kinase Activity Wound Healing Regulation Of Signal Transduction Response To Hormone Positive Regulation Of Kinase Activity MAPK Cascade Regulation Of Immune Response Response To Wounding Ras Protein Signal Transduction Positive Regulation Of Transferase Activity	Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Transferase Activity Regulation Of Immune Response Positive Regulation Of MAPK Cascade Enzyme Linked Receptor Protein Signaling Pathway Immune Response Activation Of Protein Kinase Activity Regulation Of MAPK Cascade Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAP Kinase Activity Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Blood Coagulation Hemostasis Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation ERBB Signaling Pathway Immune System Process Regulation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Defense Response Wound Healing Signaling Cellular Response To Fibroblast Growth Factor Stimulus Cell Communication Response To Fibroblast Growth Factor Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Regulation Of MAP Kinase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Catalytic Activity Response To Wounding Regulation Of Phosphorylation Regulation Of Immune System Process Positive Regulation Of Protein Modification Process
Tagcloud ?		coimmunoprecipitation crest displays docking enlightening fmtc gdnf grb2 hirschsprung inherited isoform isoforms medullar megacolon neurotrophic neurturin oncogenes owing papillary performing phosphopeptides phosphotyrosines proto ptc2 ptc2y620f ptcs rearrangements separately shc	adaptor amplifies antagonism bdl bile binder broad ccl5 chemokine conditional contributor duct elucidate exacerbated fibrogenesis fibrosis fibrotic gab1cko grb2 hepatocyte hepatocytes injections knockout ligation lipopolysaccharide liver livers myofibroblasts tetrachloride
Tagcloud (Difference) ?		coimmunoprecipitation crest displays docking enlightening fmtc gdnf hirschsprung inherited isoform isoforms medullar megacolon neurotrophic neurturin oncogenes owing papillary performing phosphopeptides phosphotyrosines proto ptc2 ptc2y620f ptcs rearrangements separately shc	adaptor amplifies antagonism bdl bile binder broad ccl5 chemokine conditional contributor duct elucidate exacerbated fibrogenesis fibrosis fibrotic gab1cko hepatocyte hepatocytes injections knockout ligation lipopolysaccharide liver livers myofibroblasts tetrachloride
Tagcloud (Intersection) ?		grb2