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RET and PTK2
Number of citations of the paper that reports this interaction (PubMedID
16153436
)
0
Data Source:
HPRD
(in vitro)
RET
PTK2
Description
ret proto-oncogene
protein tyrosine kinase 2
Image
GO Annotations
Cellular Component
Endosome
Plasma Membrane
Endosome Membrane
Membrane
Axon
Receptor Complex
Plasma Membrane Protein Complex
Stress Fiber
Nucleus
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Plasma Membrane
Focal Adhesion
Cilium
Cell Cortex
Membrane
Ciliary Basal Body
Cell Projection
Perinuclear Region Of Cytoplasm
Anchoring Junction
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Calcium Ion Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Signaling Receptor Activity
Nucleotide Binding
Actin Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Tyrosine Phosphatase Activity
Integrin Binding
Protein Binding
ATP Binding
JUN Kinase Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Protein Phosphatase Binding
SH2 Domain Binding
Molecular Function Activator Activity
Biological Process
MAPK Cascade
Ureteric Bud Development
Neural Crest Cell Migration
Embryonic Epithelial Tube Formation
Cell Adhesion
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Neuron Cell-cell Adhesion
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Nervous System Development
Axon Guidance
Posterior Midgut Development
Positive Regulation Of Gene Expression
Positive Regulation Of Neuron Projection Development
Regulation Of Cell Adhesion
Neuron Differentiation
Positive Regulation Of Cell Migration
Membrane Protein Proteolysis
Positive Regulation Of Cell Adhesion Mediated By Integrin
Ureter Maturation
Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway
Neuron Maturation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Cell Size
Positive Regulation Of DNA-templated Transcription
Response To Pain
Enteric Nervous System Development
Regulation Of Axonogenesis
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Peyer's Patch Morphogenesis
Cellular Response To Retinoic Acid
Positive Regulation Of Metanephric Glomerulus Development
Lymphocyte Migration Into Lymphoid Organs
GDF15-GFRAL Signaling Pathway
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Angiogenesis
Placenta Development
Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Regulation Of Cell-matrix Adhesion
Heart Morphogenesis
Signal Complex Assembly
Epidermal Growth Factor Receptor Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Axon Guidance
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Regulation Of Endothelial Cell Migration
Regulation Of Epithelial Cell Migration
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of Fibroblast Migration
Cell Migration
Peptidyl-tyrosine Phosphorylation
Negative Regulation Of Cell-cell Adhesion
Establishment Of Cell Polarity
Cell Differentiation
Regulation Of Cell Adhesion
Positive Regulation Of Cell Migration
Regulation Of Cell Adhesion Mediated By Integrin
Detection Of Muscle Stretch
Netrin-activated Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of Cell Population Proliferation
Negative Regulation Of Apoptotic Process
Regulation Of GTPase Activity
Regulation Of Cell Differentiation
Regulation Of Osteoblast Differentiation
Positive Regulation Of Protein Kinase Activity
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Cell Motility
Regulation Of Multicellular Organismal Process
Regulation Of Cytoskeleton Organization
Regulation Of Focal Adhesion Assembly
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Growth Hormone Receptor Signaling Pathway
Positive Regulation Of Wound Healing
Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress
Positive Regulation Of Macrophage Proliferation
Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Anoikis
Pathways
RAF/MAP kinase cascade
RET signaling
NPAS4 regulates expression of target genes
Formation of the nephric duct
Formation of the ureteric bud
Apoptotic cleavage of cellular proteins
Regulation of actin dynamics for phagocytic cup formation
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
NCAM signaling for neurite out-growth
NCAM signaling for neurite out-growth
Signal regulatory protein family interactions
EPHB-mediated forward signaling
EPHB-mediated forward signaling
DCC mediated attractive signaling
DCC mediated attractive signaling
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs
RAF/MAP kinase cascade
MET activates PTK2 signaling
Extra-nuclear estrogen signaling
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
FCGR3A-mediated phagocytosis
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs
Sorafenib
1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
Vandetanib
Cabozantinib
Regorafenib
Ponatinib
Lenvatinib
Fostamatinib
Amuvatinib
Selpercatinib
Pralsetinib
Endostatin
7-PYRIDIN-2-YL-N-(3,4,5-TRIMETHOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINE
2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDE
Fostamatinib
Diseases
Congenital central hypoventilation syndrome (CCHS)
Hirschsprung disease (HD)
Thyroid cancer
Renal agenesis and Renal adysplasia
GWAS
Blood protein levels (
30072576
)
Cannabis dependence symptom count (
27028160
)
Hirschsprung disease (
19196962
25310821
27702942
29379196
30031151
)
Smoking behaviour (cigarettes smoked per day) (
31089300
)
Acute graft versus host disease in bone marrow transplantation (recipient effect) (
27595289
)
Apolipoprotein B levels (
32203549
)
Appendicular lean mass (
33097823
)
Atrial fibrillation (
29892015
30061737
)
Deep white matter hyperintensities (
32517579
)
Diastolic blood pressure (
30224653
)
LDL cholesterol levels (
32203549
)
Mean corpuscular hemoglobin (
27863252
)
Mood instability (
31168069
)
Multisite chronic pain (
33830993
)
Nickel levels (
26025379
)
PR interval (
32439900
)
Red cell distribution width (
32888494
)
Response to interferon beta therapy (
21502966
)
Smoking status (ever vs never smokers) (
30643258
)
Interacting Genes
46 interacting genes:
AKAP5
CBL
CBLB
CRK
DOK1
DOK2
DOK3
DOK4
DOK5
DOK6
DUSP26
ERBB2
FBXO7
FRS2
GAB1
GDNF
GFRA1
GRB10
GRB2
GRB7
IKBKG
LRRK1
MAPK1
MAPK14
MAPK3
MAPK8
NEDD4
NOTCH2NLA
NOTCH3
NRTN
PDLIM7
PIK3R1
PLCG1
PRKAR2A
PTK2
PTPN11
PTPRA
PTPRF
PTPRR
SHC1
SHC3
SHC4
SNCA
SRC
STAT3
TLN1
117 interacting genes:
ACTN1
APP
ARHGAP26
ASAP1
ATG12
BBS10
BCAR1
BIN1
BMX
CCR5
CD47
CD79B
CIB1
CRK
CSK
CSPG4
CXCR4
DCC
DDX39A
DEF6
DLGAP3
DNM2
DOK4
EEF1G
EFS
EGFR
EPHA2
EPHB2
EPS8L2
ERBB2
ERBB3
EZR
FBP1
FGR
FLT1
FLT4
FYN
GIT1
GRB2
GRB7
GSK3B
GZMB
HES1
HSPA13
IGHM
INSR
IRS1
ITGAV
ITGB1
ITGB2
ITGB3
ITGB4
ITGB5
JAK2
KCNB1
KCNMA1
LCK
LPXN
LYN
MAPK8IP3
MDM2
MICAL1
MISP
MORC3
NACAD
NASP
NCK1
NCK2
NEDD8
NEDD9
NEO1
PDGFRB
PIAS1
PIK3R1
PIK3R3
PKD1
PLCG1
PPP1CB
PTK2B
PTPN11
PTPN12
PTPRH
PXN
RAC1
RB1CC1
RET
RIPK1
ROCK1
SAE1
SELE
SH2D1A
SH2D1B
SHC1
SKP2
SOCS1
SOCS2
SOCS3
SORBS1
SRC
SRPK1
STAT1
SYK
TGFB1I1
TLN1
TNFRSF1A
TNS1
TNS3
TP53
TRIM15
TRIO
TRIP6
TSC2
VCL
WEE2-AS1
YES1
ZFYVE21
ZNF331
Entrez ID
5979
5747
HPRD ID
01266
02859
Ensembl ID
ENSG00000165731
ENSG00000169398
Uniprot IDs
A0A087WWB1
A0AAQ5BH28
B4DGX8
P07949
A0A8Q3WLM4
B4DWJ1
E5RFW9
E7ESA6
Q05397
Q59GM6
Q59GN8
PDB IDs
2IVS
2IVT
2IVU
2IVV
2X2K
2X2L
2X2M
2X2U
4CKI
4CKJ
4UX8
5AMN
5FM2
5FM3
6FEK
6GL7
6I82
6I83
6NE7
6NEC
6NJA
6Q2J
6Q2N
6Q2O
6Q2R
6Q2S
6VHG
7DU8
7DU9
7DUA
7JU5
7JU6
7NZN
7RUN
1K04
1K05
1MP8
1OW6
1OW7
1OW8
2ETM
2IJM
3B71
3BZ3
3PXK
3S9O
4EBV
4EBW
4GU6
4GU9
4I4E
4I4F
4K8A
4K9Y
4KAB
4KAO
4NY0
4Q9S
6I8Z
6LES
6PW8
6YOJ
6YQ1
6YR9
6YT6
6YVS
6YVY
6YXV
7PI4
7W7Z
7W8B
7W8I
7W9U
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
ERBB Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Phosphotyrosine Residue Binding
Receptor Tyrosine Kinase Binding
Intracellular Signal Transduction
Regulation Of Signal Transduction
Neurotrophin TRKA Receptor Binding
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Cytosol
Insulin Receptor Signaling Pathway
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Intracellular Signal Transduction
Insulin-like Growth Factor Receptor Signaling Pathway
Intracellular Signaling Cassette
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Response To Growth Factor
Positive Regulation Of Signal Transduction
ERBB2 Signaling Pathway
Plasma Membrane
Ephrin Receptor Binding
Regulation Of MAPK Cascade
Focal Adhesion
Regulation Of Cell Adhesion
Cellular Response To Growth Factor Stimulus
Cytoplasm
MAP Kinase Activity
Negative Regulation Of Immune System Process
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Protein Domain Specific Binding
Schwann Cell Development
Positive Regulation Of Macrophage Proliferation
Positive Regulation Of Cell Migration
Protein Phosphatase Binding
Protein Tyrosine Phosphatase Activity
Response To Epidermal Growth Factor
Positive Regulation Of Cell Motility
Regulation Of Immune System Process
Negative Regulation Of Signal Transduction
Positive Regulation Of Locomotion
Stress-activated MAPK Cascade
Insulin Receptor Binding
Regulation Of Locomotion
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Focal Adhesion
Signal Transduction
Cell Migration
Cell Motility
Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Protein Tyrosine Kinase Activity
Anchoring Junction
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Adhesion
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Cell Adhesion
Regulation Of MAPK Cascade
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Plasma Membrane
Regulation Of Apoptotic Process
Response To Growth Factor
Positive Regulation Of Cell Adhesion
Positive Regulation Of MAPK Cascade
Phosphotyrosine Residue Binding
Regulation Of Programmed Cell Death
Peptidyl-tyrosine Phosphorylation
Regulation Of Cell Migration
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Immune System Process
Regulation Of Cell Motility
Regulation Of Cellular Component Organization
Ruffle Membrane
Integrin-mediated Signaling Pathway
Regulation Of Locomotion
Regulation Of Immune System Process
Protein Kinase Activity
Intracellular Signal Transduction
Immune System Process
Non-membrane Spanning Protein Tyrosine Kinase Activity
Regulation Of Developmental Process
Epidermal Growth Factor Receptor Signaling Pathway
Cellular Response To Oxygen-containing Compound
Protein Phosphorylation
Receptor Complex
Ephrin Receptor Signaling Pathway
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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