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RET and NOTCH2NLA
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid, two hybrid)
RET
NOTCH2NLA
Description
ret proto-oncogene
notch 2 N-terminal like A
Image
No pdb structure
GO Annotations
Cellular Component
Endosome
Plasma Membrane
Endosome Membrane
Membrane
Axon
Receptor Complex
Plasma Membrane Protein Complex
Extracellular Region
Cytoplasm
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Calcium Ion Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Signaling Receptor Activity
Notch Binding
Calcium Ion Binding
Protein Binding
Biological Process
MAPK Cascade
Ureteric Bud Development
Neural Crest Cell Migration
Embryonic Epithelial Tube Formation
Cell Adhesion
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Neuron Cell-cell Adhesion
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Nervous System Development
Axon Guidance
Posterior Midgut Development
Positive Regulation Of Gene Expression
Positive Regulation Of Neuron Projection Development
Regulation Of Cell Adhesion
Neuron Differentiation
Positive Regulation Of Cell Migration
Membrane Protein Proteolysis
Positive Regulation Of Cell Adhesion Mediated By Integrin
Ureter Maturation
Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway
Neuron Maturation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Cell Size
Positive Regulation Of DNA-templated Transcription
Response To Pain
Enteric Nervous System Development
Regulation Of Axonogenesis
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Peyer's Patch Morphogenesis
Cellular Response To Retinoic Acid
Positive Regulation Of Metanephric Glomerulus Development
Lymphocyte Migration Into Lymphoid Organs
GDF15-GFRAL Signaling Pathway
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Notch Signaling Pathway
Cerebral Cortex Development
Cell Differentiation
Positive Regulation Of Notch Signaling Pathway
Pathways
RAF/MAP kinase cascade
RET signaling
NPAS4 regulates expression of target genes
Formation of the nephric duct
Formation of the ureteric bud
NOTCH2 Activation and Transmission of Signal to the Nucleus
NOTCH2 Activation and Transmission of Signal to the Nucleus
Expression of NOTCH2NL genes
Drugs
Sorafenib
1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
Vandetanib
Cabozantinib
Regorafenib
Ponatinib
Lenvatinib
Fostamatinib
Amuvatinib
Selpercatinib
Pralsetinib
Diseases
Congenital central hypoventilation syndrome (CCHS)
Hirschsprung disease (HD)
Thyroid cancer
Renal agenesis and Renal adysplasia
GWAS
Blood protein levels (
30072576
)
Cannabis dependence symptom count (
27028160
)
Hirschsprung disease (
19196962
25310821
27702942
29379196
30031151
)
Smoking behaviour (cigarettes smoked per day) (
31089300
)
Interacting Genes
46 interacting genes:
AKAP5
CBL
CBLB
CRK
DOK1
DOK2
DOK3
DOK4
DOK5
DOK6
DUSP26
ERBB2
FBXO7
FRS2
GAB1
GDNF
GFRA1
GRB10
GRB2
GRB7
IKBKG
LRRK1
MAPK1
MAPK14
MAPK3
MAPK8
NEDD4
NOTCH2NLA
NOTCH3
NRTN
PDLIM7
PIK3R1
PLCG1
PRKAR2A
PTK2
PTPN11
PTPRA
PTPRF
PTPRR
SHC1
SHC3
SHC4
SNCA
SRC
STAT3
TLN1
361 interacting genes:
ACY3
ADAM12
ADAMTSL3
ADAMTSL4
ADAMTSL5
ADCK5
AGXT
ALDH16A1
ALDH3B1
ALPI
ALPP
ANKS1A
AQP1
AQP5
ARID3A
ASPSCR1
ATG9A
ATP5F1D
BCAM
BCL6B
BLCAP
BMP7
BRME1
C11orf87
CA6
CARHSP1
CATSPER1
CCDC26
CCDC93
CCER1
CD164
CDK5R1
CELF5
CERK
CHCHD3
CHDH
CHIC2
CHRD
CHRNG
CLDN2
CLEC18A
CNNM3
COL8A1
CRACR2A
CRCT1
CREB5
CRH
CRY2
CSF1
CST2
CST9L
CTNNBIP1
CTSG
CTSZ
CXCL16
CXCL5
CYP21A2
CYSRT1
DAGLB
DALRD3
DBH
DGCR6
DGKQ
DHRS1
DMRT3
DNAL4
DOCK2
DRD5
EFNA3
EIF4E2
ELANE
EMC7
EPHB6
ESR2
F10
FAAH
FADS2
FAM124B
FAM221A
FAM74A4
FAM90A1
FARS2
FASLG
FBXL18
FBXW5
FOXB1
FRS3
FTHL17
FZD10
GABRD
GARIN5B
GARIN6
GATA2
GEM
GFOD1
GIP
GLP1R
GLRX3
GLYAT
GNAI2
GNE
GNMT
GSTP1
GTF3C5
H2AC15
HAPLN2
HBA1
HBA2
HBZ
HCK
HHEX
HOXA1
HOXB9
HOXC8
HPCAL1
HSBP1
HSD3B7
HSPA12B
HSPBP1
HSPD1
ICAM4
IFI30
IGSF8
IL10
IL2RG
INO80B
INPP5D
INS
ITGB2
ITGB4
ITGB5
JOSD1
KCNS2
KCTD15
KIF1A
KLHL38
KLK8
KPRP
KRT20
KRT83
KRTAP10-1
KRTAP10-10
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP12-1
KRTAP12-2
KRTAP12-3
KRTAP12-4
KRTAP13-2
KRTAP13-3
KRTAP13-4
KRTAP2-3
KRTAP2-4
KRTAP26-1
KRTAP3-1
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP4-4
KRTAP4-5
KRTAP4-7
KRTAP5-11
KRTAP5-3
KRTAP5-4
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-3
KRTAP9-4
KRTAP9-8
LCE1A
LCE1B
LCE1D
LCE1E
LCE1F
LCE2A
LCE2B
LCE2C
LCE2D
LCE3A
LCE3C
LCE3D
LCE3E
LCE4A
LCE5A
LIMS2
LIN7A
LINC00526
LINC00656
LMNTD2
LMO2
LNX1
LONRF3
LRCH4
LRFN4
LYVE1
MACO1
MAPKBP1
MARK4
MATN3
MELTF
MOS
MRGBP
MRPL40
MTA1
MVP
MXD3
MXI1
MYO15B
MYPOP
NAB2
NAXD
NECTIN2
NECTIN3
NEDD9
NEU2
NMU
NMUR2
NPBWR2
NPDC1
NPPB
NR1D2
NTM
NTN4
NUBP2
NUFIP2
OLFM2
OTX1
P2RX4
P2RX7
P2RY6
PCED1A
PCED1B
PCSK5
PDE9A
PGAP6
PGLS
PHLDA1
PID1
PIGS
PLEKHN1
PLPP2
PLSCR4
POLR2G
POM121L8P
POMGNT2
PRF1
PRKAA2
PRPF31
PRPS2
PRR19
PRR35
PSMA1
PSMG2
PTGER3
PTK7
PTPMT1
PTPN23
PVR
QPRT
R3HDM2
RAB3IL1
RAMP3
RASD1
RCHY1
RECK
RET
RGL2
RNF111
RPS19BP1
RPS28
RTN4RL1
SCNM1
SDCBP
SELENOM
SEMA3B
SEMA4C
SHANK3
SHFL
SLC22A23
SLC22A5
SLC23A1
SLC25A10
SLC25A6
SLC43A2
SLC5A5
SLC68A1
SLC6A20
SMARCD2
SMARCE1
SMCP
SMOC1
SNAI1
SPATA24
SPATA31J1
SPATA8
SPG7
SPINK2
SPPL2C
SPRY1
STAC
STK16
TAPBPL
TBC1D10C
TBC1D16
TEDC2
THAP7
THEMIS2
TINAGL1
TLE5
TMEFF2
TMEM150A
TMEM231
TMEM41A
TMIE
TNIP3
TNK2
TNP2
TNS2
TRAPPC14
TRIM27
TRIM42
TROAP
TRPV6
TSPAN4
TTPA
TXNDC5
UBQLN4
UTP23
UXT
VASN
WDR25
WT1-AS
XCL2
YIPF3
ZDHHC1
ZFTRAF1
ZFYVE21
ZNF124
ZNF319
ZNF32
ZNF330
ZNF408
ZNF414
ZNF417
ZNF439
ZNF440
ZNF446
ZNF497
ZNF580
ZNF581
ZNF587
ZNF648
ZNF672
ZNF688
ZNF786
ZNF837
Entrez ID
5979
388677
HPRD ID
01266
14833
Ensembl ID
ENSG00000165731
ENSG00000264343
Uniprot IDs
A0A087WWB1
A0AAQ5BH28
B4DGX8
P07949
A0A8I5KR58
Q7Z3S9
PDB IDs
2IVS
2IVT
2IVU
2IVV
2X2K
2X2L
2X2M
2X2U
4CKI
4CKJ
4UX8
5AMN
5FM2
5FM3
6FEK
6GL7
6I82
6I83
6NE7
6NEC
6NJA
6Q2J
6Q2N
6Q2O
6Q2R
6Q2S
6VHG
7DU8
7DU9
7DUA
7JU5
7JU6
7NZN
7RUN
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
ERBB Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Phosphotyrosine Residue Binding
Receptor Tyrosine Kinase Binding
Intracellular Signal Transduction
Regulation Of Signal Transduction
Neurotrophin TRKA Receptor Binding
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Cytosol
Insulin Receptor Signaling Pathway
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Intracellular Signal Transduction
Insulin-like Growth Factor Receptor Signaling Pathway
Intracellular Signaling Cassette
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Response To Growth Factor
Positive Regulation Of Signal Transduction
ERBB2 Signaling Pathway
Plasma Membrane
Ephrin Receptor Binding
Regulation Of MAPK Cascade
Focal Adhesion
Regulation Of Cell Adhesion
Cellular Response To Growth Factor Stimulus
Cytoplasm
MAP Kinase Activity
Negative Regulation Of Immune System Process
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Protein Domain Specific Binding
Schwann Cell Development
Positive Regulation Of Macrophage Proliferation
Positive Regulation Of Cell Migration
Protein Phosphatase Binding
Protein Tyrosine Phosphatase Activity
Response To Epidermal Growth Factor
Positive Regulation Of Cell Motility
Regulation Of Immune System Process
Negative Regulation Of Signal Transduction
Positive Regulation Of Locomotion
Stress-activated MAPK Cascade
Insulin Receptor Binding
Regulation Of Locomotion
Intermediate Filament
Keratin Filament
Protein Binding
Keratinization
Epidermis Development
Hair Cycle
Identical Protein Binding
Carbon Dioxide Transport
Nitric Oxide Transport
Purinergic Nucleotide Receptor Signaling Pathway
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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