GAB1 and PDGFRB

Number of citations of the paper that reports this interaction (PMID 14973141)
10

Data Source:
HPRD (in vitro)

		GAB1	PDGFRB
Gene Name		GRB2-associated binding protein 1	platelet-derived growth factor receptor, beta polypeptide
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleus Cytoplasm Plasma Membrane Focal Adhesion Cell Surface Membrane Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Apical Plasma Membrane Intrinsic Component Of Plasma Membrane Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Signal Transducer Activity SH3/SH2 Adaptor Activity Protein Binding	Protein Tyrosine Kinase Activity Platelet Activating Factor Receptor Activity Platelet-derived Growth Factor-activated Receptor Activity Platelet-derived Growth Factor Beta-receptor Activity Receptor Binding Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Protein Kinase Binding Vascular Endothelial Growth Factor Binding Phosphatidylinositol 3-kinase Binding Platelet-derived Growth Factor Binding
	Biological Process	Response To Oxidative Stress Epidermal Growth Factor Receptor Signaling Pathway Activation Of JUN Kinase Activity Heart Development Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Regulation Of Cell Migration Fc-epsilon Receptor Signaling Pathway Innate Immune Response Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Labyrinthine Layer Development Interleukin-6-mediated Signaling Pathway	In Utero Embryonic Development Tissue Homeostasis Glycosaminoglycan Biosynthetic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Toxic Substance Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Smooth Muscle Cell Migration Cell Migration Peptidyl-tyrosine Phosphorylation Adrenal Gland Development Positive Regulation Of Cell Migration Response To Estradiol Positive Regulation Of Phosphoprotein Phosphatase Activity Response To Retinoic Acid Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Collagen Biosynthetic Process Response To Fluid Shear Stress Cell Migration Involved In Vasculogenesis Metanephric Mesenchymal Cell Migration Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Aorta Morphogenesis Cellular Response To Platelet-derived Growth Factor Stimulus Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Wound Healing Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Mitotic Nuclear Division Phosphatidylinositol Metabolic Process Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Smooth Muscle Cell Proliferation Skeletal System Morphogenesis Smooth Muscle Tissue Development Inner Ear Development Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Chemotaxis Cardiac Myofibril Assembly Response To Hyperoxia Cell Chemotaxis Cell Migration Involved In Coronary Angiogenesis Retina Vasculature Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Smooth Muscle Cell Chemotaxis Metanephric Mesenchyme Development Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Metanephric Glomerular Capillary Formation Metanephric Comma-shaped Body Morphogenesis Metanephric S-shaped Body Morphogenesis Positive Regulation Of Calcium Ion Import Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of DNA Biosynthetic Process
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling IRS-mediated signalling IGF1R signaling cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling IRS-related events triggered by IGF1R PI3K/AKT activation Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR PI3K Cascade Innate Immune System Signaling by Insulin receptor Signaling by PDGF Signalling by NGF DAP12 interactions Insulin receptor signalling cascade GAB1 signalosome IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR IRS-mediated signalling Downstream signal transduction Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Signaling by FGFR mutants PI3K/AKT Signaling in Cancer Constitutive Signaling by EGFRvIII PI3K Cascade Adaptive Immune System	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs			Becaplermin Sorafenib Imatinib Dasatinib Sunitinib Pazopanib Regorafenib
Diseases
GWAS		Asthma ( 21804548)
Protein-Protein Interactions		31 interactors: ARHGAP32 C1QBP CRK CRKL EGFR EPOR FRS2 GAB2 GRAP2 GRB2 GTF2A1L INPP5D INSR LAT2 MAP3K3 MAPK1 MAPK3 MAPK4 MARK2 MET MST1R PDGFRB PIK3CG PIK3R1 PLCG1 PLCG2 PTPN11 PTPN18 RET SHC1 SOS1	59 interactors: ARAF BAG1 CAV1 CAV3 CBL COPA COPB1 CRK EGFR EIF2AK2 FYN GAB1 GRB10 GRB14 GRB2 GRB7 ITGB3 JAK1 JAK2 KLHL12 KRTAP4-12 NCK1 NCK2 NEDD4 PDAP1 PDGFB PDGFD PDGFRA PIK3C2B PIK3CA PIK3R1 PIK3R2 PIK3R3 PLCG1 PRDX2 PTK2 PTPN1 PTPN11 PTPN2 PTPRJ RAF1 RASA1 S1PR1 SHC1 SLC9A3R1 SNX1 SNX2 SNX4 SOCS1 SRC STAT1 STAT3 STAT5A STAT5B SYNGAP1 TRIP6 TYK2 VAV1 YES1
Entrez ID		2549	5159
HPRD ID		05116	01423
Ensembl ID		ENSG00000109458	ENSG00000113721
Uniprot IDs		Q13480 Q9HA84	P09619 Q59F04
PDB IDs			1GQ5 1H9O 1LWP 2L6W 2PLD 2PLE 3MJG
Enriched GO Terms of Interacting Partners?		Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Transferase Activity Regulation Of Immune Response Positive Regulation Of MAPK Cascade Enzyme Linked Receptor Protein Signaling Pathway Immune Response Activation Of Protein Kinase Activity Regulation Of MAPK Cascade Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAP Kinase Activity Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Blood Coagulation Hemostasis Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation ERBB Signaling Pathway Immune System Process Regulation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Defense Response Wound Healing Signaling Cellular Response To Fibroblast Growth Factor Stimulus Cell Communication Response To Fibroblast Growth Factor Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Regulation Of MAP Kinase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Catalytic Activity Response To Wounding Regulation Of Phosphorylation Regulation Of Immune System Process Positive Regulation Of Protein Modification Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organonitrogen Compound Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Signal Transduction Regulation Of Signaling Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Phosphorylation Regulation Of Body Fluid Levels Regulation Of Immune System Process Response To Peptide Hormone Signal Transduction Regulation Of Immune Response Response To Peptide Blood Coagulation Hemostasis Regulation Of Phosphorus Metabolic Process Signaling Cell Communication Innate Immune Response Response To Organonitrogen Compound Cellular Response To Hormone Stimulus Regulation Of Kinase Activity Wound Healing Immune System Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Organic Substance Fc Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Intracellular Signal Transduction Locomotion Positive Regulation Of Signal Transduction Response To Wounding Cell Migration Fibroblast Growth Factor Receptor Signaling Pathway Response To Hormone Neurotrophin TRK Receptor Signaling Pathway Defense Response Neurotrophin Signaling Pathway Leukocyte Migration Cell Motility Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response Regulation Of Protein Phosphorylation Response To Organic Substance
Tagcloud ?		adaptor amplifies antagonism bdl bile binder broad ccl5 chemokine conditional contributor duct elucidate exacerbated fibrogenesis fibrosis fibrotic gab1cko grb2 hepatocyte hepatocytes injections knockout ligation lipopolysaccharide liver livers myofibroblasts tetrachloride	14q32 5q31 5q33 apart apl aspirate break complication cytogenetic cytogenetics exon firstly fusion infrequent kiaa1509 myeloid neoplasm neoplasms partner promyelocytic q32 q33 rara rarely rearrangement rt trip11 undetectable xy
Tagcloud (Difference) ?		adaptor amplifies antagonism bdl bile binder broad ccl5 chemokine conditional contributor duct elucidate exacerbated fibrogenesis fibrosis fibrotic gab1cko grb2 hepatocyte hepatocytes injections knockout ligation lipopolysaccharide liver livers myofibroblasts tetrachloride	14q32 5q31 5q33 apart apl aspirate break complication cytogenetic cytogenetics exon firstly fusion infrequent kiaa1509 myeloid neoplasm neoplasms partner promyelocytic q32 q33 rara rarely rearrangement rt trip11 undetectable xy
Tagcloud (Intersection) ?