GAB1 and SH2D3A

Number of citations of the paper that reports this interaction (PubMedID 24728074)
77

Data Source:
BioGRID (pull down)

		GAB1	SH2D3A
Description		GRB2 associated binding protein 1	SH2 domain containing 3A
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cell-cell Junction
	Molecular Function	Protein Binding Signaling Adaptor Activity	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Angiogenesis Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Intracellular Signal Transduction Endothelial Cell Chemotaxis Vascular Endothelial Growth Factor Signaling Pathway Vasodilation Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Mechanical Stimulus	JNK Cascade Small GTPase-mediated Signal Transduction
Pathways		PI3K Cascade Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PIP3 activates AKT signaling GAB1 signalosome PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer Constitutive Signaling by EGFRvIII PI-3K cascade:FGFR1 PI-3K cascade:FGFR2 PI-3K cascade:FGFR3 PI-3K cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates PI3K/AKT signaling RET signaling MET activates PTPN11 MET activates RAP1 and RAC1 MET receptor recycling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Activated NTRK2 signals through PI3K Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants
Drugs
Diseases
GWAS		Asthma ( 21804548) Diastolic blood pressure ( 27841878) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate in non-diabetics ( 31451708) Height ( 31562340) Malaria ( 31844061) Systolic blood pressure ( 27841878) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		74 interacting genes: AKT1 ARHGAP32 BCAR3 BLK BLNK BTK C1QBP CRK CRKL EGFR EPOR ERBB2 FCGR2B FES FRS2 GAB2 GRAP2 GRB2 GTF2A1L HCK HSH2D INPP5D INPPL1 INSR ITK JAK1 LAT2 MAP3K3 MAPK1 MAPK3 MAPK4 MARK2 MET MST1R NCK1 NCK2 PDGFRB PIK3CG PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PTK6 PTPN11 PTPN18 RASA1 RET SH2D1B SH2D2A SH2D3A SHC1 SHC3 SLA SLA2 SOCS3 SOCS6 SOS1 SRC STAP1 SUPT6H SYK SYP TEC TNS1 TNS3 TNS4 TRIM15 VAV1 VAV2 VAV3 WEE2-AS1 YAP1 YES1	7 interacting genes: BCAR1 CENPB EGFR ERBB2 ERBB3 GAB1 NXF1
Entrez ID		2549	10045
HPRD ID		05116	05283
Ensembl ID		ENSG00000109458	ENSG00000125731
Uniprot IDs		B7Z3B9 Q13480 Q9HA84	A8K2M8 Q9BRG2
PDB IDs		4QSY
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Protein Tyrosine Kinase Activity Positive Regulation Of Immune System Process Regulation Of Immune System Process ERBB Signaling Pathway Intracellular Signaling Cassette Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Immune Response Protein Kinase Activity Regulation Of Signal Transduction Immune System Process Antigen Receptor-mediated Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Kinase Activity B Cell Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Cell Activation Regulation Of MAPK Cascade Non-membrane Spanning Protein Tyrosine Kinase Activity Leukocyte Activation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Cytosol Positive Regulation Of MAPK Cascade Lymphocyte Activation Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Cell Migration Phosphorylation Insulin Receptor Signaling Pathway Immune Effector Process Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Immune System Process Receptor Tyrosine Kinase Binding Regulation Of Cell Adhesion	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway ERBB2 Signaling Pathway ERBB3:ERBB2 Complex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ErbB-3 Class Receptor Binding Basal Plasma Membrane ERBB2-EGFR Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Tyrosine Kinase Activator Activity Protein Tyrosine Kinase Activity Schwann Cell Development Peripheral Nervous System Development Receptor Complex Positive Regulation Of Epithelial Cell Proliferation Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transmembrane Signaling Receptor Activity Basolateral Plasma Membrane Growth Factor Binding Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Cellular Response To Growth Factor Stimulus Animal Organ Development Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Cycle G1/S Phase Transition Response To Growth Factor Multivesicular Body, Internal Vesicle Lumen Regulation Of Angiogenesis Glial Cell Development Ribonucleoside-diphosphate Reductase Activity Regulation Of Vasculature Development Wound Healing Neuron Differentiation Cell Migration Insulin Receptor Signaling Pathway Regulation Of Epithelial Cell Proliferation Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Growth Ruffle Membrane Focal Adhesion Shc-EGFR Complex Myelination Axon Ensheathment Positive Regulation Of Cardiac Muscle Tissue Development
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