RET and AKAP5

Number of citations of the paper that reports this interaction (PubMedID 11886862)
0

Data Source:
HPRD (in vivo)

		RET	AKAP5
Description		ret proto-oncogene	A-kinase anchoring protein 5
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GO Annotations	Cellular Component	Endosome Plasma Membrane Endosome Membrane Membrane Axon Receptor Complex Plasma Membrane Protein Complex	Endosome Cytosol Plasma Membrane Protein Serine/threonine Phosphatase Complex Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Membrane Dendrite Dendrite Membrane Cell Projection Dendritic Spine Membrane Raft Synapse Postsynaptic Membrane Excitatory Synapse Postsynaptic Recycling Endosome Postsynaptic Recycling Endosome Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Signaling Receptor Activity	Protein Binding Calmodulin Binding Adenylate Cyclase Binding SH3 Domain Binding Protein Phosphatase 2B Binding Beta-2 Adrenergic Receptor Binding Protein Kinase A Regulatory Subunit Binding Glutamate Receptor Binding GABA Receptor Binding Protein Kinase A Binding Molecular Adaptor Activity Scaffold Protein Binding
	Biological Process	MAPK Cascade Ureteric Bud Development Neural Crest Cell Migration Embryonic Epithelial Tube Formation Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Neuron Cell-cell Adhesion Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Posterior Midgut Development Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Regulation Of Cell Adhesion Neuron Differentiation Positive Regulation Of Cell Migration Membrane Protein Proteolysis Positive Regulation Of Cell Adhesion Mediated By Integrin Ureter Maturation Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Neuron Maturation Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Size Positive Regulation Of DNA-templated Transcription Response To Pain Enteric Nervous System Development Regulation Of Axonogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Peyer's Patch Morphogenesis Cellular Response To Retinoic Acid Positive Regulation Of Metanephric Glomerulus Development Lymphocyte Migration Into Lymphoid Organs GDF15-GFRAL Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Chemical Synaptic Transmission Regulation Of Protein Kinase A Signaling Calcineurin-NFAT Signaling Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Endosome To Plasma Membrane Protein Transport
Pathways		RAF/MAP kinase cascade RET signaling NPAS4 regulates expression of target genes Formation of the nephric duct Formation of the ureteric bud	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Trafficking of AMPA receptors ROBO receptors bind AKAP5 ROBO receptors bind AKAP5
Drugs		Sorafenib 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Vandetanib Cabozantinib Regorafenib Ponatinib Lenvatinib Fostamatinib Amuvatinib Selpercatinib Pralsetinib
Diseases		Congenital central hypoventilation syndrome (CCHS) Hirschsprung disease (HD) Thyroid cancer Renal agenesis and Renal adysplasia
GWAS		Blood protein levels ( 30072576) Cannabis dependence symptom count ( 27028160) Hirschsprung disease ( 19196962 25310821 27702942 29379196 30031151) Smoking behaviour (cigarettes smoked per day) ( 31089300)
Interacting Genes		46 interacting genes: AKAP5 CBL CBLB CRK DOK1 DOK2 DOK3 DOK4 DOK5 DOK6 DUSP26 ERBB2 FBXO7 FRS2 GAB1 GDNF GFRA1 GRB10 GRB2 GRB7 IKBKG LRRK1 MAPK1 MAPK14 MAPK3 MAPK8 NEDD4 NOTCH2NLA NOTCH3 NRTN PDLIM7 PIK3R1 PLCG1 PRKAR2A PTK2 PTPN11 PTPRA PTPRF PTPRR SHC1 SHC3 SHC4 SNCA SRC STAT3 TLN1	21 interacting genes: ADRB2 CALM1 DLG1 DLG4 FOS GABRB1 GABRB3 IQGAP1 JUN KCNJ2 MDM2 PPP3CA PRKAR1A PRKAR2A PRKAR2B PRKCA RET ROPN1 ROPN1L TP53 TRPV1
Entrez ID		5979	9495
HPRD ID		01266	05255
Ensembl ID		ENSG00000165731	ENSG00000179841
Uniprot IDs		A0A087WWB1 A0AAQ5BH28 B4DGX8 P07949	P24588 Q6PG46
PDB IDs		2IVS 2IVT 2IVU 2IVV 2X2K 2X2L 2X2M 2X2U 4CKI 4CKJ 4UX8 5AMN 5FM2 5FM3 6FEK 6GL7 6I82 6I83 6NE7 6NEC 6NJA 6Q2J 6Q2N 6Q2O 6Q2R 6Q2S 6VHG 7DU8 7DU9 7DUA 7JU5 7JU6 7NZN 7RUN	2H9R 3LL8 5NIN
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction ERBB Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Phosphotyrosine Residue Binding Receptor Tyrosine Kinase Binding Intracellular Signal Transduction Regulation Of Signal Transduction Neurotrophin TRKA Receptor Binding Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Cytosol Insulin Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Insulin-like Growth Factor Receptor Signaling Pathway Intracellular Signaling Cassette Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Response To Growth Factor Positive Regulation Of Signal Transduction ERBB2 Signaling Pathway Plasma Membrane Ephrin Receptor Binding Regulation Of MAPK Cascade Focal Adhesion Regulation Of Cell Adhesion Cellular Response To Growth Factor Stimulus Cytoplasm MAP Kinase Activity Negative Regulation Of Immune System Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Domain Specific Binding Schwann Cell Development Positive Regulation Of Macrophage Proliferation Positive Regulation Of Cell Migration Protein Phosphatase Binding Protein Tyrosine Phosphatase Activity Response To Epidermal Growth Factor Positive Regulation Of Cell Motility Regulation Of Immune System Process Negative Regulation Of Signal Transduction Positive Regulation Of Locomotion Stress-activated MAPK Cascade Insulin Receptor Binding Regulation Of Locomotion	Regulation Of Membrane Potential Intracellular Signal Transduction Response To Metal Ion Signal Transduction Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction CAMP-dependent Protein Kinase Regulator Activity Regulation Of Biological Quality Regulation Of System Process CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Regulation Of CAMP/PKA Signal Transduction Regulation Of Muscle System Process Response To Calcium Ion Protein Kinase A Catalytic Subunit Binding Regulation Of Multicellular Organismal Process Dendritic Spine Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Developmental Process Cellular Response To Metal Ion CAMP Binding Plasma Membrane System Process Glutamatergic Synapse Cellular Response To Actinomycin D Positive Regulation Of Angiotensin-activated Signaling Pathway Negative Regulation Of CAMP/PKA Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Response To Steroid Hormone Enzyme Binding Response To Toxic Substance Regulation Of Postsynaptic Membrane Potential Protein Domain Specific Binding Postsynaptic Membrane Response To Actinomycin D Extracellular Ligand-gated Monoatomic Ion Channel Activity Muscle System Process Cellular Response To UV-C Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Glomerulus Development Learning Or Memory Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ciliary Base Modulation Of Chemical Synaptic Transmission Transcription Factor AP-1 Complex Cellular Response To Histamine Response To Xenobiotic Stimulus
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