GAB1 and PTPN18

Number of citations of the paper that reports this interaction (PubMedID 14660651)
0

Data Source:
HPRD (in vitro)

		GAB1	PTPN18
Description		GRB2 associated binding protein 1	protein tyrosine phosphatase non-receptor type 18
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cell-cell Junction	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Signaling Adaptor Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity
	Biological Process	Angiogenesis Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Intracellular Signal Transduction Endothelial Cell Chemotaxis Vascular Endothelial Growth Factor Signaling Pathway Vasodilation Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Mechanical Stimulus	Blastocyst Formation Protein Dephosphorylation Negative Regulation Of ERBB Signaling Pathway
Pathways		PI3K Cascade Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PIP3 activates AKT signaling GAB1 signalosome PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer Constitutive Signaling by EGFRvIII PI-3K cascade:FGFR1 PI-3K cascade:FGFR2 PI-3K cascade:FGFR3 PI-3K cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates PI3K/AKT signaling RET signaling MET activates PTPN11 MET activates RAP1 and RAC1 MET receptor recycling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Activated NTRK2 signals through PI3K Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants	Downregulation of ERBB2 signaling Interleukin-37 signaling
Drugs
Diseases
GWAS		Asthma ( 21804548) Diastolic blood pressure ( 27841878) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate in non-diabetics ( 31451708) Height ( 31562340) Malaria ( 31844061) Systolic blood pressure ( 27841878) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		74 interacting genes: AKT1 ARHGAP32 BCAR3 BLK BLNK BTK C1QBP CRK CRKL EGFR EPOR ERBB2 FCGR2B FES FRS2 GAB2 GRAP2 GRB2 GTF2A1L HCK HSH2D INPP5D INPPL1 INSR ITK JAK1 LAT2 MAP3K3 MAPK1 MAPK3 MAPK4 MARK2 MET MST1R NCK1 NCK2 PDGFRB PIK3CG PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PTK6 PTPN11 PTPN18 RASA1 RET SH2D1B SH2D2A SH2D3A SHC1 SHC3 SLA SLA2 SOCS3 SOCS6 SOS1 SRC STAP1 SUPT6H SYK SYP TEC TNS1 TNS3 TNS4 TRIM15 VAV1 VAV2 VAV3 WEE2-AS1 YAP1 YES1	13 interacting genes: AATK ABL1 ARHGAP5 CNKSR1 CSK EGFR ERBB2 GAB1 PSTPIP1 PSTPIP2 SNCA SRC TEC
Entrez ID		2549	26469
HPRD ID		05116	05961
Ensembl ID		ENSG00000109458	ENSG00000072135
Uniprot IDs		B7Z3B9 Q13480 Q9HA84	Q99952
PDB IDs		4QSY	2OC3 4GFU 4GFV 4NND
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Protein Tyrosine Kinase Activity Positive Regulation Of Immune System Process Regulation Of Immune System Process ERBB Signaling Pathway Intracellular Signaling Cassette Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Immune Response Protein Kinase Activity Regulation Of Signal Transduction Immune System Process Antigen Receptor-mediated Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Kinase Activity B Cell Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Cell Activation Regulation Of MAPK Cascade Non-membrane Spanning Protein Tyrosine Kinase Activity Leukocyte Activation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Cytosol Positive Regulation Of MAPK Cascade Lymphocyte Activation Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Cell Migration Phosphorylation Insulin Receptor Signaling Pathway Immune Effector Process Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Immune System Process Receptor Tyrosine Kinase Binding Regulation Of Cell Adhesion	Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase Activity ERBB Signaling Pathway Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Perinuclear Region Of Cytoplasm Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB2 Signaling Pathway Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade ATP Binding Response To Growth Factor Cytoplasm SH2 Domain Binding Protein Phosphorylation Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Phosphorylation Transferase Activity Nucleotide Binding Cell-cell Junction ERBB2-EGFR Signaling Pathway Protein Domain Specific Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Signal Transduction Cytosol Cell Surface Receptor Signaling Pathway Cytoskeleton Plasma Membrane Integrin-mediated Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Response To Epinephrine Immune Response-regulating Cell Surface Receptor Signaling Pathway Ruffle Membrane Protein Tyrosine Kinase Activator Activity Positive Regulation Of Locomotion Neuron Apoptotic Process Negative Regulation Of Cell Adhesion T Cell Receptor Signaling Pathway Glial Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Endocytosis Proline-rich Region Binding Positive Regulation Of Phosphate Metabolic Process Regulation Of Locomotion Regulation Of Multicellular Organismal Process Regulation Of MAPK Cascade
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