RET and NRTN

Number of citations of the paper that reports this interaction (PMID 9192898)
26

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		RET	NRTN
Gene Name		ret proto-oncogene	neurturin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Intracellular Membrane-bounded Organelle Receptor Complex Membrane Raft	Extracellular Region Axon
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Activity Calcium Ion Binding Protein Binding ATP Binding	Receptor Binding Growth Factor Activity
	Biological Process	MAPK Cascade Ureteric Bud Development Neural Crest Cell Migration Embryonic Epithelial Tube Formation Protein Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Neuron Cell-cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Posterior Midgut Development Positive Regulation Of Neuron Projection Development Positive Regulation Of Neuron Maturation Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Membrane Protein Proteolysis Positive Regulation Of Cell Adhesion Mediated By Integrin Ureter Maturation Response To Drug Neuron Maturation Positive Regulation Of Cell Size Positive Regulation Of Transcription, DNA-templated Response To Pain Enteric Nervous System Development Regulation Of Axonogenesis Retina Development In Camera-type Eye Innervation Peyer's Patch Morphogenesis Cellular Response To Retinoic Acid Positive Regulation Of Metanephric Glomerulus Development Lymphocyte Migration Into Lymphoid Organs Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	MAPK Cascade Neural Crest Cell Migration Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Nerve Development Neuron Projection Development
Pathways			NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth
Drugs		Imatinib
Diseases
GWAS		Hirschsprung's disease ( 19196962)	N-glycan levels ( 21203500)
Protein-Protein Interactions		36 interactors: AKAP5 CBL CBLB CRK DOK1 DOK2 DOK3 DOK4 DOK5 DOK6 FRS2 GAB1 GDNF GFRA1 GRB10 GRB2 GRB7 IKBKG MAPK1 MAPK14 MAPK3 MAPK8 NOTCH2NL NOTCH3 NRTN PDLIM7 PIK3R1 PLCG1 PRKAR2A PTK2 PTPN11 PTPRF SHC1 SHC3 SRC STAT3	3 interactors: GFRA1 GFRA2 RET
Entrez ID		5979	4902
HPRD ID		01266	03604
Ensembl ID		ENSG00000165731	ENSG00000171119
Uniprot IDs		P07949 Q9BTX6	Q99748
PDB IDs		1XPD 2IVS 2IVT 2IVU 2IVV 2X2K 2X2L 2X2M 2X2U
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Signaling Cellular Response To Growth Factor Stimulus Cell Communication Response To Growth Factor Response To Peptide Response To Peptide Hormone Fc Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Positive Regulation Of Signal Transduction Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Cellular Response To Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cellular Response To Hormone Stimulus Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Insulin Response To Organonitrogen Compound Blood Coagulation Hemostasis Activation Of Protein Kinase Activity Cellular Response To Organic Substance Response To Stimulus Innate Immune Response Fc-epsilon Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Signaling Positive Regulation Of Protein Kinase Activity Wound Healing Regulation Of Signal Transduction Response To Hormone Positive Regulation Of Kinase Activity MAPK Cascade Regulation Of Immune Response Response To Wounding Ras Protein Signal Transduction Positive Regulation Of Transferase Activity	Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Posterior Midgut Development Positive Regulation Of Neuron Maturation Lymphocyte Migration Into Lymphoid Organs Cellular Response To Organic Substance Peyer's Patch Morphogenesis Positive Regulation Of Metanephric Glomerulus Development Ureter Maturation Regulation Of Neuron Maturation Nervous System Development Cytokine-mediated Signaling Pathway Positive Regulation Of Glomerulus Development Negative Regulation Of Protein Autophosphorylation Response To Organic Substance Enteric Nervous System Development Cellular Response To Cytokine Stimulus Neuron Cell-cell Adhesion Positive Regulation Of Cell Size Ureter Development Positive Regulation Of Cell Adhesion Mediated By Integrin Peyer's Patch Development Cell Surface Receptor Signaling Pathway Midgut Development Response To Cytokine Regulation Of Protein Autophosphorylation Neuron Maturation Lymphocyte Migration Membrane Protein Proteolysis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Innervation Positive Regulation Of Kidney Development Neuron Development Response To Pain Regulation Of Cell Adhesion Mediated By Integrin Autonomic Nervous System Development System Development Neural Crest Cell Migration Neuron Differentiation Locomotion Multicellular Organismal Development Neural Crest Cell Development Cellular Response To Retinoic Acid Anatomical Structure Development Neural Crest Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Signal Transduction Multicellular Organismal Response To Stress
Tagcloud ?		coimmunoprecipitation crest displays docking enlightening fmtc gdnf grb2 hirschsprung inherited isoform isoforms medullar megacolon neurotrophic neurturin oncogenes owing papillary performing phosphopeptides phosphotyrosines proto ptc2 ptc2y620f ptcs rearrangements separately shc	bain biol dev division es excitotoxic gdnf gfralpha1 gfralpha2 grown immunocytochemistry injured ligands likelihood lineage manipulable modestly neurons neurotrophin neurotrophins neurturin nmda nt oligodendrocytes plating pluripotential pretreatment ret vulnerability
Tagcloud (Difference) ?		coimmunoprecipitation crest displays docking enlightening fmtc grb2 hirschsprung inherited isoform isoforms medullar megacolon neurotrophic oncogenes owing papillary performing phosphopeptides phosphotyrosines proto ptc2 ptc2y620f ptcs rearrangements separately shc	bain biol dev division es excitotoxic gfralpha1 gfralpha2 grown immunocytochemistry injured ligands likelihood lineage manipulable modestly neurons neurotrophin neurotrophins nmda nt oligodendrocytes plating pluripotential pretreatment vulnerability
Tagcloud (Intersection) ?		gdnf neurturin ret