RET and SNCA

Number of citations of the paper that reports this interaction (PubMedID 39079530)
128

Data Source:
BioGRID (two hybrid)

		RET	SNCA
Description		ret proto-oncogene	synuclein alpha
Image
GO Annotations	Cellular Component	Endosome Plasma Membrane Endosome Membrane Membrane Axon Receptor Complex Plasma Membrane Protein Complex	Extracellular Region Extracellular Space Nucleus Nuclear Outer Membrane Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Lysosome Cytosol Ribosome Cytoskeleton Plasma Membrane Cell Cortex Synaptic Vesicle Actin Cytoskeleton Membrane Inclusion Body Axon Growth Cone Cytoplasmic Vesicle Membrane Synaptic Vesicle Membrane Platelet Alpha Granule Membrane Protein-containing Complex Cell Projection Neuronal Cell Body Terminal Bouton Axon Terminus Synapse Perinuclear Region Of Cytoplasm Presynapse Postsynapse Supramolecular Fiber
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Signaling Receptor Activity	SNARE Binding Magnesium Ion Binding Transcription Cis-regulatory Region Binding Actin Binding Enzyme Inhibitor Activity Protein Kinase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Fatty Acid Binding Copper Ion Binding Calcium Ion Binding Protein Binding Phospholipid Binding Microtubule Binding Enzyme Activator Activity Ferrous Iron Binding Zinc Ion Binding Lipid Binding Oxidoreductase Activity Kinesin Binding Enzyme Binding Protein Domain Specific Binding Hsp70 Protein Binding Histone Binding Identical Protein Binding Alpha-tubulin Binding Phospholipase Binding Metal Ion Binding Tau Protein Binding Beta-tubulin Binding Phosphoprotein Binding Molecular Adaptor Activity Phospholipase D Inhibitor Activity Dynein Complex Binding Protein Sequestering Activity Transporter Regulator Activity Cuprous Ion Binding
	Biological Process	MAPK Cascade Ureteric Bud Development Neural Crest Cell Migration Embryonic Epithelial Tube Formation Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Neuron Cell-cell Adhesion Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Posterior Midgut Development Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Regulation Of Cell Adhesion Neuron Differentiation Positive Regulation Of Cell Migration Membrane Protein Proteolysis Positive Regulation Of Cell Adhesion Mediated By Integrin Ureter Maturation Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Neuron Maturation Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Size Positive Regulation Of DNA-templated Transcription Response To Pain Enteric Nervous System Development Regulation Of Axonogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Peyer's Patch Morphogenesis Cellular Response To Retinoic Acid Positive Regulation Of Metanephric Glomerulus Development Lymphocyte Migration Into Lymphoid Organs GDF15-GFRAL Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Negative Regulation Of Transcription By RNA Polymerase II Microglial Cell Activation Positive Regulation Of Receptor Recycling Positive Regulation Of Neurotransmitter Secretion Synaptic Transmission, Dopaminergic Fatty Acid Metabolic Process Neutral Lipid Metabolic Process Phospholipid Metabolic Process Glutathione Metabolic Process Mitochondrial Membrane Organization Chemical Synaptic Transmission Neurotransmitter Secretion Adult Locomotory Behavior Response To Xenobiotic Stimulus Response To Iron(II) Ion Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Glutamate Secretion Regulation Of Dopamine Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Priming Negative Regulation Of Microtubule Polymerization Receptor Internalization Protein Destabilization Response To Magnesium Ion Response To Lipopolysaccharide Response To Type II Interferon Cellular Response To Oxidative Stress SNARE Complex Assembly Positive Regulation Of SNARE Complex Assembly Regulation Of Locomotion Response To Cocaine Dopamine Biosynthetic Process Dopamine Metabolic Process Mitochondrial ATP Synthesis Coupled Electron Transport Regulation Of Macrophage Activation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Endocytosis Negative Regulation Of Exocytosis Positive Regulation Of Exocytosis Negative Regulation Of Dopamine Metabolic Process Regulation Of Neurotransmitter Secretion Behavioral Response To Cocaine Regulation Of Neuronal Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Positive Regulation Of Inflammatory Response Positive Regulation Of Synaptic Transmission Synapse Organization Regulation Of Acyl-CoA Biosynthetic Process Protein Complex Oligomerization Protein Tetramerization Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neuron Apoptotic Process Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Serotonin Uptake Regulation Of Norepinephrine Uptake Negative Regulation Of Norepinephrine Uptake Calcium Ion Homeostasis Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Positive Regulation Of Inositol Phosphate Biosynthetic Process Membrane Organization Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Response To Interleukin-1 Cellular Response To Copper Ion Cellular Response To Epinephrine Stimulus Supramolecular Fiber Organization Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Regulation Of Synaptic Vesicle Recycling Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Desipramine Positive Regulation Of Protein Localization To Cell Periphery Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Presynapse Assembly Amyloid Fibril Formation Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		RAF/MAP kinase cascade RET signaling NPAS4 regulates expression of target genes Formation of the nephric duct Formation of the ureteric bud	Amyloid fiber formation PKR-mediated signaling
Drugs		Sorafenib 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Vandetanib Cabozantinib Regorafenib Ponatinib Lenvatinib Fostamatinib Amuvatinib Selpercatinib Pralsetinib	Resveratrol Dequalinium Copper
Diseases		Congenital central hypoventilation syndrome (CCHS) Hirschsprung disease (HD) Thyroid cancer Renal agenesis and Renal adysplasia	Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)
GWAS		Blood protein levels ( 30072576) Cannabis dependence symptom count ( 27028160) Hirschsprung disease ( 19196962 25310821 27702942 29379196 30031151) Smoking behaviour (cigarettes smoked per day) ( 31089300)	Anxiety ( 33859377) Blood protein levels ( 30072576) Dementia with Lewy bodies ( 29263008) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Feeling nervous ( 29500382) Neurociticism ( 29500382) Parkinson's disease ( 28892059 34064523 32310270 32201043 31660654 19915575 28011712 21084426 19915576 20070850 20711177 21044948 21292315 21738487 22438815 22451204 24511991 25064009 27182965) Parkinson's disease (age of onset) ( 30957308 31660654 33884653) Parkinson's disease in GBA mutation carriers ( 31755958) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Response to bupropion in depression ( 27622933)
Interacting Genes		46 interacting genes: AKAP5 CBL CBLB CRK DOK1 DOK2 DOK3 DOK4 DOK5 DOK6 DUSP26 ERBB2 FBXO7 FRS2 GAB1 GDNF GFRA1 GRB10 GRB2 GRB7 IKBKG LRRK1 MAPK1 MAPK14 MAPK3 MAPK8 NEDD4 NOTCH2NLA NOTCH3 NRTN PDLIM7 PIK3R1 PLCG1 PRKAR2A PTK2 PTPN11 PTPRA PTPRF PTPRR SHC1 SHC3 SHC4 SNCA SRC STAT3 TLN1	419 interacting genes: A1BG ACAP1 ACKR2 ACTA1 ACTR1A ADAP2 ADM ADORA2A ADRB2 AGO2 AKT1 AMBRA1 ANGPT1 ANXA2 ANXA6 AP1G2 AP2M1 APBB1 APLP1 APOC2 APOC3 APOE APP ARAP2 ARAP3 ARF1 ARF3 ARF5 ARF6 ARFGAP1 ARFGAP2 ARFGAP3 ARHGAP15 ARPP19 ARRB1 ARRB2 ARSA ASGR1 ASGR2 ATP13A1 AXIN2 B4GALT1 BAD BAG5 BASP1 BCL2L1 BCL6 BDH2 BET1 CACFD1 CACNB4 CACNG5 CACYBP CALM1 CALU CAMK1D CAP1 CAV1 CAV2 CAV3 CBLC CBS CCL3 CCR1 CDC42 CDC42EP2 CDC42EP3 CDC42SE1 CDH13 CDK4 CHMP1B CHMP2A CHMP2B CHMP4B CHMP6 CHRM3 CHRM4 CHRM5 CHRNA4 CHRNB2 CHRND CKB CLEC10A CLEC4M CLSTN2 CLTB CLTCL1 CNIH2 CNN3 CNST COL25A1 COLEC11 COLQ COPG1 CPEB1 CPLX4 CPNE1 CPNE3 CRIPT CRYAB CSNK1A1 CSNK1D CSNK1E CSNK1G1 CSNK1G2 CSNK1G3 CSNK2A1 CSNK2A2 CTNND1 CTSD CXCL16 CYCS CYTH2 CYTH3 CYTH4 DBH DDX1 DDX17 DLG3 DMTN DNAJA1 DNAJC5 DNM1 DNM3 DOCK7 DOLPP1 DTNB DVL1 DYRK1A EDC4 EEF1D EGFR EGR1 EGR3 EHD3 EIF3C EIF3G EIF3L ELK1 ELMO3 ELMOD3 ENC1 ENSA EPN2 ERBB3 ERGIC2 ERGIC3 EXOC1 F2R FAM120A FAM98A FBXL5 FBXW7 FGFR4 FGR FOLR3 FSHR FTH1 FYN GAB2 GABARAPL1 GABRA4 GAD1 GBA1 GHRH GNAI1 GNAI3 GRK1 GRK2 GRK3 GRK4 GRK5 GRK6 GULP1 H1-1 H1-2 H2AC11 HFE HOMER3 HSD17B4 HSPA1B HSPA6 HSPA8 HSPB2 HSPB6 HSPB8 HTR1B ICA1 IQSEC2 ITSN2 KAT2A KAT2B KCNJ10 KCNMB4 KDR KIAA1191 KLC1 KLK6 LAMP2 LDLRAP1 LEFTY2 LGALS3 LILRB1 LIN7B LIN7C LRFN2 LRP12 LRPAP1 LRRC15 LRRC4 LYN MAP1B MAP1LC3B MAP4K2 MAPK1 MAPK8 MAPK8IP1 MAPKAPK5 MAPT MARCO MDM2 MEF2D MLC1 MME MMRN1 MS4A2 MSR1 MT-CO1 MT-CO3 MVB12A MYH9 MYLK2 MYO6 NAP1L1 NECAP1 NECAP2 NEDD4 NEDD4L NKD2 NME1 NRP1 OPTN OSBPL11 OSBPL5 OSBPL7 PABPC1 PACSIN1 PAICS PAK3 PARD6A PARK7 PATL1 PCLO PDCD6IP PDE4DIP PDIA2 PDLIM7 PELP1 PF4 PHACTR1 PHETA1 PIAS3 PIK3CD PIP5K1B PIP5K1C PLAT PLCB2 PLD1 PLG PLK1 PLK3 PLS3 PML POPDC1 PPP3CA PRDX1 PREP PRKAR1A PRKCE PRKN PSD3 PSMA1 PSMB1 PTBP1 PTK2B PTPN18 PTPN6 PTPRR PTX3 QARS1 RAB11A RAB11B RAB11FIP1 RAB11FIP2 RAB17 RAB1A RAB20 RAB26 RAB3A RAB4A RAB5A RAB5B RAB5C RABAC1 RABEP1 RAC1 RALA RASGRP2 RBBP4 RET RHOA RHOBTB3 RNF10 ROPN1B RPH3AL RPL18A RPL22 RPS12 RPS25 RUFY1 S100A9 SAMD4A SAP30BP SCAMP1 SCARA5 SCYL1 SDF4 SELE SEMA4F SEPTIN2 SEPTIN3 SEPTIN4 SFRP4 SH3BP4 SIAH2 SLC22A2 SLC30A8 SLC35E2B SLC5A7 SLC6A1 SLC6A15 SLC6A20 SLC6A3 SLC6A7 SMAP2 SMURF2 SNCAIP SNCB SNX1 SNX16 SPAG9 SPTBN1 SQSTM1 SRC SRI ST13 STAM STAMBP STUB1 STX11 STX18 STX1B STX2 STXBP3 SYK SYN1 SYN3 SYPL2 SYT3 SYTL4 TFG TFRC TGFB2 TGM1 TGM2 TH TOM1 TOMM20 TOR1A TPPP TPRG1L TRAPPC2 TRAPPC6B TRIP11 TRPV6 TSG101 TUBA1A TXLNA UBA52 UBB UBC UBE2D2 UBE2W UBL3 USP2 USP33 USP47 USP7 USP8 VAMP2 VCP VPS13C VPS25 VPS28 VPS29 VPS36 VPS37D VPS45 VPS4A VTA1 WASHC2A WTAP YOD1 YTHDF1 YTHDF2 YWHAB YWHAE YWHAH ZRANB1
Entrez ID		5979	6622
HPRD ID		01266	01227
Ensembl ID		ENSG00000165731	ENSG00000145335
Uniprot IDs		A0A087WWB1 A0AAQ5BH28 B4DGX8 P07949	H6UYS5 P37840
PDB IDs		2IVS 2IVT 2IVU 2IVV 2X2K 2X2L 2X2M 2X2U 4CKI 4CKJ 4UX8 5AMN 5FM2 5FM3 6FEK 6GL7 6I82 6I83 6NE7 6NEC 6NJA 6Q2J 6Q2N 6Q2O 6Q2R 6Q2S 6VHG 7DU8 7DU9 7DUA 7JU5 7JU6 7NZN 7RUN	1XQ8 2JN5 2KKW 2M55 2N0A 2X6M 3Q25 3Q26 3Q27 3Q28 3Q29 4BXL 4R0U 4R0W 4RIK 4RIL 4ZNN 5CRW 6A6B 6CT7 6CU7 6CU8 6H6B 6I42 6L1T 6L1U 6L4S 6LRQ 6OSJ 6OSL 6OSM 6PEO 6PES 6RT0 6RTB 6SST 6SSX 6UFR 6XYO 6XYP 6XYQ 7C1D 7E0F 7L7H 7LC9 7NCA 7NCG 7NCH 7NCI 7NCJ 7NCK 7OZG 7OZH 7STX 7UAK 7V47 7V48 7V49 7V4A 7V4B 7V4C 7V4D 7WMM 7WNZ 7WO0 7XJX 7XO0 7XO1 7XO2 7XO3 7YK2 7YK8 7YNF 7YNG 7YNL 7YNM 7YNN 7YNO 7YNP 7YNQ 7YNR 7YNS 7YNT 8A4L 8A9L 8ADS 8ADU 8ADV 8ADW 8AEX 8B9V 8BQV 8BQW 8CE7 8CEB 8CYR 8CYS 8CYT 8CYV 8CYW 8CYX 8CYY 8CZ0 8CZ1 8CZ2 8CZ3 8CZ6 8FPT 8G0L 8GF7 8H03 8H04 8H05 8HZB 8HZC 8HZS 8JEX 8JEY 8JJV 8JLY 8OG0 8OJR 8OL8 8OQI 8PIX 8PJO 8PK2 8PK4 8QPZ 8RI9 8RQM 8RRR 8UKA 8X7B 8X7L 8X7M 8X7O 8X7P 8X7Q 8X7R 8XWD 8Y2P 8Y2Q 8ZLI 8ZLO 8ZLP 8ZMY 8ZWH 8ZWI 8ZWJ 8ZWK 9CD9 9CDA 9CK3 9CX6 9D5C 9EUU 9FYP 9HGR 9HGS 9HXA 9IJP
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction ERBB Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Phosphotyrosine Residue Binding Receptor Tyrosine Kinase Binding Intracellular Signal Transduction Regulation Of Signal Transduction Neurotrophin TRKA Receptor Binding Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Cytosol Insulin Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Insulin-like Growth Factor Receptor Signaling Pathway Intracellular Signaling Cassette Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Response To Growth Factor Positive Regulation Of Signal Transduction ERBB2 Signaling Pathway Plasma Membrane Ephrin Receptor Binding Regulation Of MAPK Cascade Focal Adhesion Regulation Of Cell Adhesion Cellular Response To Growth Factor Stimulus Cytoplasm MAP Kinase Activity Negative Regulation Of Immune System Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Domain Specific Binding Schwann Cell Development Positive Regulation Of Macrophage Proliferation Positive Regulation Of Cell Migration Protein Phosphatase Binding Protein Tyrosine Phosphatase Activity Response To Epidermal Growth Factor Positive Regulation Of Cell Motility Regulation Of Immune System Process Negative Regulation Of Signal Transduction Positive Regulation Of Locomotion Stress-activated MAPK Cascade Insulin Receptor Binding Regulation Of Locomotion	Vesicle-mediated Transport Endocytosis Import Into Cell Regulation Of Vesicle-mediated Transport Regulation Of Transport Plasma Membrane Intracellular Protein Localization Protein Transport Regulation Of Signaling Cytoplasm Establishment Of Protein Localization Regulation Of Cell Communication Establishment Of Localization In Cell Regulation Of Cellular Component Organization Synapse Endosome Membrane Regulation Of Endocytosis Cytosol Cellular Localization Vesicle Organization Extracellular Exosome Regulation Of Protein Localization Receptor-mediated Endocytosis Regulation Of Biological Quality Regulation Of Signal Transduction Regulation Of Secretion Intracellular Transport Regulation Of Secretion By Cell Positive Regulation Of Transport Membrane Organization Secretion Cytoplasmic Vesicle Exocytosis Multivesicular Body Assembly Secretion By Cell Positive Regulation Of Cellular Component Organization Multivesicular Body Organization Early Endosome Endosome Organization Presynapse Modulation Of Chemical Synaptic Transmission Intracellular Protein Transport Ubiquitin Protein Ligase Binding Endosomal Transport Positive Regulation Of Catabolic Process Organelle Localization Glutamatergic Synapse Regulation Of Intracellular Signal Transduction Regulation Of Cellular Localization
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