RET and DOK3

Number of citations of the paper that reports this interaction (PubMedID 11470823)
64

Data Source:
HPRD (two hybrid)

		RET	DOK3
Description		ret proto-oncogene	docking protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Endosome Membrane Membrane Axon Receptor Complex Plasma Membrane Protein Complex	Cytoplasm Plasma Membrane Membrane Secretory Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Signaling Receptor Activity	Protein Binding
	Biological Process	MAPK Cascade Ureteric Bud Development Neural Crest Cell Migration Embryonic Epithelial Tube Formation Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Neuron Cell-cell Adhesion Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Posterior Midgut Development Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Regulation Of Cell Adhesion Neuron Differentiation Positive Regulation Of Cell Migration Membrane Protein Proteolysis Positive Regulation Of Cell Adhesion Mediated By Integrin Ureter Maturation Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Neuron Maturation Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Size Positive Regulation Of DNA-templated Transcription Response To Pain Enteric Nervous System Development Regulation Of Axonogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Peyer's Patch Morphogenesis Cellular Response To Retinoic Acid Positive Regulation Of Metanephric Glomerulus Development Lymphocyte Migration Into Lymphoid Organs GDF15-GFRAL Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction
Pathways		RAF/MAP kinase cascade RET signaling NPAS4 regulates expression of target genes Formation of the nephric duct Formation of the ureteric bud	Neutrophil degranulation
Drugs		Sorafenib 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Vandetanib Cabozantinib Regorafenib Ponatinib Lenvatinib Fostamatinib Amuvatinib Selpercatinib Pralsetinib
Diseases		Congenital central hypoventilation syndrome (CCHS) Hirschsprung disease (HD) Thyroid cancer Renal agenesis and Renal adysplasia
GWAS		Blood protein levels ( 30072576) Cannabis dependence symptom count ( 27028160) Hirschsprung disease ( 19196962 25310821 27702942 29379196 30031151) Smoking behaviour (cigarettes smoked per day) ( 31089300)	Coronary artery disease ( 29212778) Inflammatory bowel disease ( 23128233) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		46 interacting genes: AKAP5 CBL CBLB CRK DOK1 DOK2 DOK3 DOK4 DOK5 DOK6 DUSP26 ERBB2 FBXO7 FRS2 GAB1 GDNF GFRA1 GRB10 GRB2 GRB7 IKBKG LRRK1 MAPK1 MAPK14 MAPK3 MAPK8 NEDD4 NOTCH2NLA NOTCH3 NRTN PDLIM7 PIK3R1 PLCG1 PRKAR2A PTK2 PTPN11 PTPRA PTPRF PTPRR SHC1 SHC3 SHC4 SNCA SRC STAT3 TLN1	31 interacting genes: A1CF ABL1 ANKS1A APPL1 APPL2 COX5B CRK CSK DOK1 DOK2 DOK5 DTX2 FYN GCM2 HOXA1 INPP5D LCK LYN MDFI PLEKHA3 PPIH PRKAB2 RBPMS RET RIN3 SHC3 SHE SPAG8 STAT3 TNS2 TRAF1
Entrez ID		5979	79930
HPRD ID		01266	16834
Ensembl ID		ENSG00000165731	ENSG00000146094
Uniprot IDs		A0A087WWB1 A0AAQ5BH28 B4DGX8 P07949	A0A6M4C8X9 D6RAM3 Q7L591
PDB IDs		2IVS 2IVT 2IVU 2IVV 2X2K 2X2L 2X2M 2X2U 4CKI 4CKJ 4UX8 5AMN 5FM2 5FM3 6FEK 6GL7 6I82 6I83 6NE7 6NEC 6NJA 6Q2J 6Q2N 6Q2O 6Q2R 6Q2S 6VHG 7DU8 7DU9 7DUA 7JU5 7JU6 7NZN 7RUN
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction ERBB Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Phosphotyrosine Residue Binding Receptor Tyrosine Kinase Binding Intracellular Signal Transduction Regulation Of Signal Transduction Neurotrophin TRKA Receptor Binding Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Cytosol Insulin Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Insulin-like Growth Factor Receptor Signaling Pathway Intracellular Signaling Cassette Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Response To Growth Factor Positive Regulation Of Signal Transduction ERBB2 Signaling Pathway Plasma Membrane Ephrin Receptor Binding Regulation Of MAPK Cascade Focal Adhesion Regulation Of Cell Adhesion Cellular Response To Growth Factor Stimulus Cytoplasm MAP Kinase Activity Negative Regulation Of Immune System Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Domain Specific Binding Schwann Cell Development Positive Regulation Of Macrophage Proliferation Positive Regulation Of Cell Migration Protein Phosphatase Binding Protein Tyrosine Phosphatase Activity Response To Epidermal Growth Factor Positive Regulation Of Cell Motility Regulation Of Immune System Process Negative Regulation Of Signal Transduction Positive Regulation Of Locomotion Stress-activated MAPK Cascade Insulin Receptor Binding Regulation Of Locomotion	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Ephrin Receptor Binding Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Ephrin Receptor Signaling Pathway Protein Tyrosine Kinase Activity Antigen Receptor-mediated Signaling Pathway Fc-gamma Receptor Signaling Pathway Signal Transduction T Cell Costimulation T Cell Receptor Signaling Pathway Fc Receptor Signaling Pathway Response To Hepatocyte Growth Factor Positive Regulation Of Macropinocytosis Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Protein Localization To Membrane Regulation Of MAPK Cascade Regulation Of Endocytosis CD8 Receptor Binding Positive Regulation Of Cell Adhesion Intracellular Signal Transduction Regulation Of Immune Response Cytosol Positive Regulation Of Lymphocyte Activation Regulation Of Phagocytosis Identical Protein Binding Regulation Of Toll-like Receptor 4 Signaling Pathway Macropinosome Immune Response-activating Signaling Pathway Negative Regulation Of Immune System Process Cytoplasm Regulation Of Cell Migration Regulation Of Vesicle-mediated Transport Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway SH2 Domain Binding Leukocyte Migration Regulation Of Immune System Process Regulation Of Cell Motility Positive Regulation Of Cell Activation Positive Regulation Of Pinocytosis Regulation Of Signal Transduction Regulation Of Locomotion
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