RET and DOK3

Number of citations of the paper that reports this interaction (PMID 11470823)
30

Data Source:
HPRD (two hybrid)

		RET	DOK3
Gene Name		ret proto-oncogene	docking protein 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Intracellular Membrane-bounded Organelle Receptor Complex Membrane Raft	Cytoplasm Plasma Membrane
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Activity Calcium Ion Binding Protein Binding ATP Binding	Insulin Receptor Binding Protein Binding
	Biological Process	MAPK Cascade Ureteric Bud Development Neural Crest Cell Migration Embryonic Epithelial Tube Formation Protein Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Neuron Cell-cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Posterior Midgut Development Positive Regulation Of Neuron Projection Development Positive Regulation Of Neuron Maturation Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Membrane Protein Proteolysis Positive Regulation Of Cell Adhesion Mediated By Integrin Ureter Maturation Response To Drug Neuron Maturation Positive Regulation Of Cell Size Positive Regulation Of Transcription, DNA-templated Response To Pain Enteric Nervous System Development Regulation Of Axonogenesis Retina Development In Camera-type Eye Innervation Peyer's Patch Morphogenesis Cellular Response To Retinoic Acid Positive Regulation Of Metanephric Glomerulus Development Lymphocyte Migration Into Lymphoid Organs Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Ras Protein Signal Transduction
Pathways
Drugs		Imatinib
Diseases
GWAS		Hirschsprung's disease ( 19196962)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		36 interactors: AKAP5 CBL CBLB CRK DOK1 DOK2 DOK3 DOK4 DOK5 DOK6 FRS2 GAB1 GDNF GFRA1 GRB10 GRB2 GRB7 IKBKG MAPK1 MAPK14 MAPK3 MAPK8 NOTCH2NL NOTCH3 NRTN PDLIM7 PIK3R1 PLCG1 PRKAR2A PTK2 PTPN11 PTPRF SHC1 SHC3 SRC STAT3	9 interactors: ABL1 CSK FYN INPP5D LCK LYN RBPMS RET TRAF1
Entrez ID		5979	79930
HPRD ID		01266	16834
Ensembl ID		ENSG00000165731	ENSG00000146094
Uniprot IDs		P07949 Q9BTX6	D6RAM3 Q7L591
PDB IDs		1XPD 2IVS 2IVT 2IVU 2IVV 2X2K 2X2L 2X2M 2X2U
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Signaling Cellular Response To Growth Factor Stimulus Cell Communication Response To Growth Factor Response To Peptide Response To Peptide Hormone Fc Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Positive Regulation Of Signal Transduction Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Cellular Response To Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cellular Response To Hormone Stimulus Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Insulin Response To Organonitrogen Compound Blood Coagulation Hemostasis Activation Of Protein Kinase Activity Cellular Response To Organic Substance Response To Stimulus Innate Immune Response Fc-epsilon Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Signaling Positive Regulation Of Protein Kinase Activity Wound Healing Regulation Of Signal Transduction Response To Hormone Positive Regulation Of Kinase Activity MAPK Cascade Regulation Of Immune Response Response To Wounding Ras Protein Signal Transduction Positive Regulation Of Transferase Activity	Peptidyl-tyrosine Autophosphorylation Antigen Receptor-mediated Signaling Pathway Peptidyl-tyrosine Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Migration Blood Coagulation Hemostasis Cell Motility Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction Protein Autophosphorylation Leukocyte Migration Regulation Of Signaling T Cell Costimulation Regulation Of Body Fluid Levels Wound Healing Regulation Of Cell Adhesion Positive Regulation Of Immune Response Positive Regulation Of Cell Activation Locomotion Positive Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Metabolic Process Response To Wounding T Cell Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Movement Of Cell Or Subcellular Component Regulation Of Lymphocyte Activation Positive Regulation Of Cell Differentiation Regulation Of Cell Death Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Peptidyl-amino Acid Modification B Cell Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Regulation Of Cell Activation Platelet Activation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell-cell Adhesion
Tagcloud ?		coimmunoprecipitation crest displays docking enlightening fmtc gdnf grb2 hirschsprung inherited isoform isoforms medullar megacolon neurotrophic neurturin oncogenes owing papillary performing phosphopeptides phosphotyrosines proto ptc2 ptc2y620f ptcs rearrangements separately shc	abrogation adaptor attenuates attenuation btk calcineurin cyclosporine defect deleting dispensable follicular germinal helper immunization inability nonredundant pc pcs pd pdl1 pdl2 plcgamma2 programmed reconstitution rectifies suppresses sustain tfh
Tagcloud (Difference) ?		coimmunoprecipitation crest displays docking enlightening fmtc gdnf grb2 hirschsprung inherited isoform isoforms medullar megacolon neurotrophic neurturin oncogenes owing papillary performing phosphopeptides phosphotyrosines proto ptc2 ptc2y620f ptcs rearrangements separately shc	abrogation adaptor attenuates attenuation btk calcineurin cyclosporine defect deleting dispensable follicular germinal helper immunization inability nonredundant pc pcs pd pdl1 pdl2 plcgamma2 programmed reconstitution rectifies suppresses sustain tfh
Tagcloud (Intersection) ?