GAB1 and STAP1

Number of citations of the paper that reports this interaction (PubMedID 24728074)
77

Data Source:
BioGRID (pull down)

		GAB1	STAP1
Description		GRB2 associated binding protein 1	signal transducing adaptor family member 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cell-cell Junction	Nucleus Cytoplasm Mitochondrion Cytosol Nuclear Body Protein-containing Complex
	Molecular Function	Protein Binding Signaling Adaptor Activity	Phosphotyrosine Residue Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Phospholipid Binding Protein Kinase Binding Protein Tyrosine Kinase Activator Activity Protein-macromolecule Adaptor Activity Receptor Tyrosine Kinase Binding Signaling Adaptor Activity
	Biological Process	Angiogenesis Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Intracellular Signal Transduction Endothelial Cell Chemotaxis Vascular Endothelial Growth Factor Signaling Pathway Vasodilation Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Mechanical Stimulus	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Bacterium Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Chemotaxis Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Phagocytosis, Engulfment Cellular Response To Lipopolysaccharide Negative Regulation Of Ruffle Assembly Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Microglial Cell Activation Negative Regulation Of Microglial Cell Migration Positive Regulation Of Microglial Cell Mediated Cytotoxicity
Pathways		PI3K Cascade Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PIP3 activates AKT signaling GAB1 signalosome PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer Constitutive Signaling by EGFRvIII PI-3K cascade:FGFR1 PI-3K cascade:FGFR2 PI-3K cascade:FGFR3 PI-3K cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates PI3K/AKT signaling RET signaling MET activates PTPN11 MET activates RAP1 and RAC1 MET receptor recycling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Activated NTRK2 signals through PI3K Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants
Drugs
Diseases
GWAS		Asthma ( 21804548) Diastolic blood pressure ( 27841878) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate in non-diabetics ( 31451708) Height ( 31562340) Malaria ( 31844061) Systolic blood pressure ( 27841878) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Regular attendance at a pub or social club ( 29970889)
Interacting Genes		74 interacting genes: AKT1 ARHGAP32 BCAR3 BLK BLNK BTK C1QBP CRK CRKL EGFR EPOR ERBB2 FCGR2B FES FRS2 GAB2 GRAP2 GRB2 GTF2A1L HCK HSH2D INPP5D INPPL1 INSR ITK JAK1 LAT2 MAP3K3 MAPK1 MAPK3 MAPK4 MARK2 MET MST1R NCK1 NCK2 PDGFRB PIK3CG PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PTK6 PTPN11 PTPN18 RASA1 RET SH2D1B SH2D2A SH2D3A SHC1 SHC3 SLA SLA2 SOCS3 SOCS6 SOS1 SRC STAP1 SUPT6H SYK SYP TEC TNS1 TNS3 TNS4 TRIM15 VAV1 VAV2 VAV3 WEE2-AS1 YAP1 YES1	14 interacting genes: AR EGFR ERBB2 ERBB3 ERBB4 GAB1 GRIPAP1 KIT MET PTK2B RETREG3 SH3KBP1 TEC URI1
Entrez ID		2549	26228
HPRD ID		05116	16053
Ensembl ID		ENSG00000109458	ENSG00000035720
Uniprot IDs		B7Z3B9 Q13480 Q9HA84	Q9ULZ2
PDB IDs		4QSY	1X1F 3MAZ
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Protein Tyrosine Kinase Activity Positive Regulation Of Immune System Process Regulation Of Immune System Process ERBB Signaling Pathway Intracellular Signaling Cassette Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Immune Response Protein Kinase Activity Regulation Of Signal Transduction Immune System Process Antigen Receptor-mediated Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Kinase Activity B Cell Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Cell Activation Regulation Of MAPK Cascade Non-membrane Spanning Protein Tyrosine Kinase Activity Leukocyte Activation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Cytosol Positive Regulation Of MAPK Cascade Lymphocyte Activation Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Cell Migration Phosphorylation Insulin Receptor Signaling Pathway Immune Effector Process Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Immune System Process Receptor Tyrosine Kinase Binding Regulation Of Cell Adhesion	Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Programmed Cell Death Enzyme-linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Basal Plasma Membrane Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Kinase Activity ERBB2 Signaling Pathway Receptor Complex Kinase Activity Regulation Of Programmed Cell Death Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Neuron Differentiation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of MAPK Cascade Regulation Of Biological Quality ERBB3:ERBB2 Complex Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Regulation Of Multicellular Organismal Process Positive Regulation Of Endothelial Cell Migration Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Mast Cell Differentiation Positive Regulation Of Cell Population Proliferation Regulation Of Developmental Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Migration Positive Regulation Of Phosphate Metabolic Process Cell Migration Response To Growth Factor Positive Regulation Of Cell Motility Positive Regulation Of Locomotion
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