RET and PTPRA

Number of citations of the paper that reports this interaction (PubMedID 32062451)
62

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		RET	PTPRA
Description		ret proto-oncogene	protein tyrosine phosphatase receptor type A
Image
GO Annotations	Cellular Component	Endosome Plasma Membrane Endosome Membrane Membrane Axon Receptor Complex Plasma Membrane Protein Complex	Plasma Membrane Focal Adhesion Membrane Receptor Complex Extracellular Exosome Anchoring Junction
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Signaling Receptor Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity
	Biological Process	MAPK Cascade Ureteric Bud Development Neural Crest Cell Migration Embryonic Epithelial Tube Formation Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Neuron Cell-cell Adhesion Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Posterior Midgut Development Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Regulation Of Cell Adhesion Neuron Differentiation Positive Regulation Of Cell Migration Membrane Protein Proteolysis Positive Regulation Of Cell Adhesion Mediated By Integrin Ureter Maturation Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Neuron Maturation Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Size Positive Regulation Of DNA-templated Transcription Response To Pain Enteric Nervous System Development Regulation Of Axonogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Peyer's Patch Morphogenesis Cellular Response To Retinoic Acid Positive Regulation Of Metanephric Glomerulus Development Lymphocyte Migration Into Lymphoid Organs GDF15-GFRAL Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Signal Transduction Integrin-mediated Signaling Pathway Regulation Of Focal Adhesion Assembly
Pathways		RAF/MAP kinase cascade RET signaling NPAS4 regulates expression of target genes Formation of the nephric duct Formation of the ureteric bud	NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth RAF/MAP kinase cascade
Drugs		Sorafenib 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Vandetanib Cabozantinib Regorafenib Ponatinib Lenvatinib Fostamatinib Amuvatinib Selpercatinib Pralsetinib
Diseases		Congenital central hypoventilation syndrome (CCHS) Hirschsprung disease (HD) Thyroid cancer Renal agenesis and Renal adysplasia
GWAS		Blood protein levels ( 30072576) Cannabis dependence symptom count ( 27028160) Hirschsprung disease ( 19196962 25310821 27702942 29379196 30031151) Smoking behaviour (cigarettes smoked per day) ( 31089300)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 28552196) Immature fraction of reticulocytes ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		46 interacting genes: AKAP5 CBL CBLB CRK DOK1 DOK2 DOK3 DOK4 DOK5 DOK6 DUSP26 ERBB2 FBXO7 FRS2 GAB1 GDNF GFRA1 GRB10 GRB2 GRB7 IKBKG LRRK1 MAPK1 MAPK14 MAPK3 MAPK8 NEDD4 NOTCH2NLA NOTCH3 NRTN PDLIM7 PIK3R1 PLCG1 PRKAR2A PTK2 PTPN11 PTPRA PTPRF PTPRR SHC1 SHC3 SHC4 SNCA SRC STAT3 TLN1	20 interacting genes: BCAR1 CALM1 FYN GABARAPL2 GAS1 GRB2 HSPB1 HUNK KCNA2 LCOR LINC00839 MBP PRKCD PTGER4 PTPRD PTPRF PTPRM PTPRS RET SRC
Entrez ID		5979	5786
HPRD ID		01266	01476
Ensembl ID		ENSG00000165731	ENSG00000132670
Uniprot IDs		A0A087WWB1 A0AAQ5BH28 B4DGX8 P07949	A0A1S5UZ22 B7Z2A4 P18433
PDB IDs		2IVS 2IVT 2IVU 2IVV 2X2K 2X2L 2X2M 2X2U 4CKI 4CKJ 4UX8 5AMN 5FM2 5FM3 6FEK 6GL7 6I82 6I83 6NE7 6NEC 6NJA 6Q2J 6Q2N 6Q2O 6Q2R 6Q2S 6VHG 7DU8 7DU9 7DUA 7JU5 7JU6 7NZN 7RUN	6UZT
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction ERBB Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Phosphotyrosine Residue Binding Receptor Tyrosine Kinase Binding Intracellular Signal Transduction Regulation Of Signal Transduction Neurotrophin TRKA Receptor Binding Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Cytosol Insulin Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Insulin-like Growth Factor Receptor Signaling Pathway Intracellular Signaling Cassette Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Response To Growth Factor Positive Regulation Of Signal Transduction ERBB2 Signaling Pathway Plasma Membrane Ephrin Receptor Binding Regulation Of MAPK Cascade Focal Adhesion Regulation Of Cell Adhesion Cellular Response To Growth Factor Stimulus Cytoplasm MAP Kinase Activity Negative Regulation Of Immune System Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Domain Specific Binding Schwann Cell Development Positive Regulation Of Macrophage Proliferation Positive Regulation Of Cell Migration Protein Phosphatase Binding Protein Tyrosine Phosphatase Activity Response To Epidermal Growth Factor Positive Regulation Of Cell Motility Regulation Of Immune System Process Negative Regulation Of Signal Transduction Positive Regulation Of Locomotion Stress-activated MAPK Cascade Insulin Receptor Binding Regulation Of Locomotion	Vascular Endothelial Growth Factor Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Transmembrane Receptor Protein Tyrosine Phosphatase Activity Plasma Membrane Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Synaptic Membrane Adhesion Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Ephrin Receptor Binding Cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Protein Tyrosine Phosphatase Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Defense Response Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity T Cell Costimulation Cell-cell Adhesion Phosphoprotein Phosphatase Activity Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Response To Growth Factor Fc Receptor Signaling Pathway Regulation Of Anatomical Structure Morphogenesis Immune Response-activating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Cellular Response To Hydrogen Peroxide Phospholipase Activator Activity Regulation Of Apoptotic Signaling Pathway Immune Effector Process Regulation Of Immune Response Cell-cell Junction Regulation Of Cell Migration ERBB Signaling Pathway Insulin Receptor Substrate Binding Immune Response-regulating Signaling Pathway Activation Of Immune Response Membrane Regulation Of Cell Motility Regulation Of Neuron Projection Development Protein Tyrosine Kinase Activator Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?