Wiki-Pi
About
Search
People
Updates
Search
RET and DOK4
Number of citations of the paper that reports this interaction (PubMedID
11470823
)
64
Data Source:
HPRD
(two hybrid, in vitro, in vivo)
RET
DOK4
Description
ret proto-oncogene
docking protein 4
Image
No pdb structure
GO Annotations
Cellular Component
Endosome
Plasma Membrane
Endosome Membrane
Membrane
Axon
Receptor Complex
Plasma Membrane Protein Complex
Cytoplasm
Cytosol
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Calcium Ion Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Signaling Receptor Activity
Protein Binding
Biological Process
MAPK Cascade
Ureteric Bud Development
Neural Crest Cell Migration
Embryonic Epithelial Tube Formation
Cell Adhesion
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Neuron Cell-cell Adhesion
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Nervous System Development
Axon Guidance
Posterior Midgut Development
Positive Regulation Of Gene Expression
Positive Regulation Of Neuron Projection Development
Regulation Of Cell Adhesion
Neuron Differentiation
Positive Regulation Of Cell Migration
Membrane Protein Proteolysis
Positive Regulation Of Cell Adhesion Mediated By Integrin
Ureter Maturation
Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway
Neuron Maturation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Cell Size
Positive Regulation Of DNA-templated Transcription
Response To Pain
Enteric Nervous System Development
Regulation Of Axonogenesis
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Peyer's Patch Morphogenesis
Cellular Response To Retinoic Acid
Positive Regulation Of Metanephric Glomerulus Development
Lymphocyte Migration Into Lymphoid Organs
GDF15-GFRAL Signaling Pathway
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Nervous System Development
Positive Regulation Of MAPK Cascade
Pathways
RAF/MAP kinase cascade
RET signaling
NPAS4 regulates expression of target genes
Formation of the nephric duct
Formation of the ureteric bud
RET signaling
Drugs
Sorafenib
1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
Vandetanib
Cabozantinib
Regorafenib
Ponatinib
Lenvatinib
Fostamatinib
Amuvatinib
Selpercatinib
Pralsetinib
Diseases
Congenital central hypoventilation syndrome (CCHS)
Hirschsprung disease (HD)
Thyroid cancer
Renal agenesis and Renal adysplasia
GWAS
Blood protein levels (
30072576
)
Cannabis dependence symptom count (
27028160
)
Hirschsprung disease (
19196962
25310821
27702942
29379196
30031151
)
Smoking behaviour (cigarettes smoked per day) (
31089300
)
Interacting Genes
46 interacting genes:
AKAP5
CBL
CBLB
CRK
DOK1
DOK2
DOK3
DOK4
DOK5
DOK6
DUSP26
ERBB2
FBXO7
FRS2
GAB1
GDNF
GFRA1
GRB10
GRB2
GRB7
IKBKG
LRRK1
MAPK1
MAPK14
MAPK3
MAPK8
NEDD4
NOTCH2NLA
NOTCH3
NRTN
PDLIM7
PIK3R1
PLCG1
PRKAR2A
PTK2
PTPN11
PTPRA
PTPRF
PTPRR
SHC1
SHC3
SHC4
SNCA
SRC
STAT3
TLN1
21 interacting genes:
CRK
EGFR
ERBB2
FYN
IGF1R
INCA1
INSR
LIX1
MAPRE3
OLIG1
OPRM1
PAX8
PFDN5
PTK2
RASA1
RBP7
RET
RHOU
SRC
STAT2
TEK
Entrez ID
5979
55715
HPRD ID
01266
16316
Ensembl ID
ENSG00000165731
ENSG00000125170
Uniprot IDs
A0A087WWB1
A0AAQ5BH28
B4DGX8
P07949
H3BQ19
Q8TEW6
PDB IDs
2IVS
2IVT
2IVU
2IVV
2X2K
2X2L
2X2M
2X2U
4CKI
4CKJ
4UX8
5AMN
5FM2
5FM3
6FEK
6GL7
6I82
6I83
6NE7
6NEC
6NJA
6Q2J
6Q2N
6Q2O
6Q2R
6Q2S
6VHG
7DU8
7DU9
7DUA
7JU5
7JU6
7NZN
7RUN
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
ERBB Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Phosphotyrosine Residue Binding
Receptor Tyrosine Kinase Binding
Intracellular Signal Transduction
Regulation Of Signal Transduction
Neurotrophin TRKA Receptor Binding
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Cytosol
Insulin Receptor Signaling Pathway
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Intracellular Signal Transduction
Insulin-like Growth Factor Receptor Signaling Pathway
Intracellular Signaling Cassette
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Response To Growth Factor
Positive Regulation Of Signal Transduction
ERBB2 Signaling Pathway
Plasma Membrane
Ephrin Receptor Binding
Regulation Of MAPK Cascade
Focal Adhesion
Regulation Of Cell Adhesion
Cellular Response To Growth Factor Stimulus
Cytoplasm
MAP Kinase Activity
Negative Regulation Of Immune System Process
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Protein Domain Specific Binding
Schwann Cell Development
Positive Regulation Of Macrophage Proliferation
Positive Regulation Of Cell Migration
Protein Phosphatase Binding
Protein Tyrosine Phosphatase Activity
Response To Epidermal Growth Factor
Positive Regulation Of Cell Motility
Regulation Of Immune System Process
Negative Regulation Of Signal Transduction
Positive Regulation Of Locomotion
Stress-activated MAPK Cascade
Insulin Receptor Binding
Regulation Of Locomotion
Protein Tyrosine Kinase Activity
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Activity
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Anatomical Structure Morphogenesis
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of MAPK Cascade
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Cell Communication
Ephrin Receptor Signaling Pathway
Regulation Of Signaling
Regulation Of Developmental Process
Protein Kinase Activity
Peptidyl-tyrosine Phosphorylation
Regulation Of Cellular Component Organization
Regulation Of Signal Transduction
Regulation Of Cell Morphogenesis
Positive Regulation Of Intracellular Signal Transduction
Kinase Activity
Regulation Of MAPK Cascade
Positive Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Receptor Complex
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Apoptotic Process
Positive Regulation Of Cell Motility
Dendritic Spine Maintenance
Positive Regulation Of Locomotion
Regulation Of Programmed Cell Death
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Cell Shape
Cell Surface Receptor Signaling Pathway
Cellular Response To Growth Factor Stimulus
Regulation Of Cell Migration
Epidermal Growth Factor Receptor Signaling Pathway
Phosphatidylinositol 3-kinase Binding
Signal Transduction
Regulation Of Cell Motility
Response To Growth Factor
Positive Regulation Of Small GTPase Mediated Signal Transduction
Regulation Of Locomotion
Regulation Of Cell-substrate Junction Organization
ERBB Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of Cell Adhesion
ERBB2 Signaling Pathway
Protein Phosphorylation
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?