ATXN1 and TRIP6

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ATXN1	TRIP6
Gene Name		ataxin 1	thyroid hormone receptor interactor 6
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear RNA Export Factor Complex Nuclear Inclusion Body Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Interleukin-1 Receptor Complex
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Protein C-terminus Binding Poly(U) RNA Binding Poly(G) Binding Identical Protein Binding Protein Self-association	Interleukin-1 Receptor Binding Protein Binding Zinc Ion Binding Kinase Binding Poly(A) RNA Binding Thyroid Hormone Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Processing Adult Locomotory Behavior Visual Learning Negative Regulation Of Phosphorylation Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Lung Alveolus Development Nuclear Export Regulation Of Excitatory Postsynaptic Membrane Potential	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of Cell Migration Focal Adhesion Assembly
Pathways
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 19451621) Gambling ( 22780124) Major depressive disorder ( 23377640)	Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020)
Protein-Protein Interactions		252 interactors: ACACA ACOT7 ADCY6 ADD3 AHDC1 AKT1 ANKHD1 ANP32A APBB1 ARHGAP32 ARID5A ASNS ATF5 ATP1A3 ATP6V0D1 ATXN1L ATXN2 ATXN2L BAALC BASP1 BATF2 BEND2 BTG3 C1orf94 C2orf27B CAMK2B CCDC136 CCNK CDIP1 CDK6 CFL1 CHRNA7 CIC CIRBP CLASRP CLCN2 CLEC4F COIL CPSF7 CREM CRIP2 CRK CRY2 CST3 DAZAP2 DCTN3 DHRSX DHX37 DIXDC1 DMPK DNAJA3 DOCK5 DZIP3 EFEMP2 EHMT1 EIF1AY EIF1B EIF3F EIF4ENIF1 ELP5 ENTPD6 ESRP1 ESRRA ETV4 FAM193B FAM21C FAM46A FAM46B FAR1 FAT4 FDPS FHL2 FOSL1 FUBP3 FYN GAPDH GATAD1 GCA GCFC2 GGA2 GMEB2 GPATCH8 GSPT1 HEY2 HEYL HIST1H3A HIVEP1 HNRNPLL HOTAIR HPCAL1 HSFX1 HSPA1A HYPM IGF2R IL34 ILVBL IMMT IPO8 IST1 ITGB4 KAT5 KAT6A KCNAB2 KCTD15 KIAA1549L KIAA2026 KIF22 KLF11 KLHL12 KLHL8 KMT2B LASP1 LDB1 LITAF LOC401442 LOXL1 LPAR2 LRSAM1 MAGEB18 MAGEB2 MAGEB6 MATN2 MBP MED15 METTL17 MLST8 MSMO1 MSX2 MTERF4 MYO18A NARS NCAM1 NCOR1 NCOR2 NLK NPHP3 NR4A1 NUDT21 NUMBL NUTM2B OAZ1 OPCML OTX2 PEPD PHPT1 PIAS1 PIM2 PLEKHB1 PML POM121 PPAT PPP6R2 PQBP1 PRDM1 PRR20A PRRC2A PRRC2B PSMC3 PSPH PTGDS PUM1 QKI QRICH1 R3HDM1 R3HDM2 RAD54L2 RAI2 RAPGEF1 RAPGEF4 RBFOX1 RBFOX2 RBM26 RBPMS RCN1 REL RHOXF2 RNF31 RNF4 SAR1A SEMA4G SETD2 SF1 SGMS1 SIX5 SLC25A51 SLC4A2 SLC51A SLC6A13 SMARCC2 SPEN SREBF1 SREBF2 ST6GALNAC6 STAC2 STAM2 SUGP2 SUMO1 SUMO2 SUPT20H SV2A SYBU TBC1D5 TBX15 TCAP TCEANC TCTA TDP2 TMX2 TOLLIP TOMM20 TOX4 TP53I11 TRAF2 TRIM32 TRIM38 TRIP6 TSC1 TTC19 U2AF2 UBAP2L UBE2E3 UBE2I UBQLN4 UHRF1BP1L UHRF2 UNK USP54 USP7 VCP VSNL1 VSTM2L WBSCR16 WNK1 WNK2 YWHAE YWHAZ YY1AP1 ZBTB32 ZC3H10 ZC3H7B ZCCHC13 ZHX1 ZHX2 ZHX3 ZNF276 ZNF488 ZNF609 ZNF804A ZSCAN1 ZSWIM8 ZXDC ZYX	105 interactors: ABI2 ADAMTSL4 AQP1 ARNT2 ATN1 ATP5O ATXN1 BCAR1 BYSL CATSPER1 CBLC CCL5 CEP57L1 CNTF CREB5 CTAG2 DHX37 DMRT3 DTX2 EXOC3-AS1 FAM124B FAM154A FAM46C FASLG FHL3 FRS3 GDPD5 GFI1B GNAI2 GSE1 HLA-DPB1 HOXA1 HOXA9 HOXB9 HYKK ILF3 INCA1 KIAA1683 KIF1A KIR2DL4 KLK15 KRTAP26-1 LMO2 LOC149950 LPAR2 MAPKBP1 MEMO1 METTL17 MSRB3 MVP NCK2 NEDD9 NEU4 NUP210 ODF1 OIP5 OTUB2 PDGFRB PDLIM4 PIN1 POM121 POM121L4P PPP1R16A PRKAA1 PRKAA2 PTK2 PTPN13 PXN RAD23A RERE RFX3 RHOA RHOQ RNF213 RNF214 SCRIB SIK3 SLC15A3 SLC25A6 SMAD1 SON SRC STAC STK16 SVIL SYNGAP1 TAB1 TCAF1 TEKT4 THRB TLR2 TMSB4X TPM3 TPM4 TRAF3IP2 TRAPPC2L TRIM29 TTLL10 TXN2 TXNDC5 VCL WT1-AS XRCC6BP1 YPEL3 ZBP1
Entrez ID		6310	7205
HPRD ID		03333	04242
Ensembl ID		ENSG00000124788	ENSG00000087077
Uniprot IDs		P54253 Q96FF1	F2ZC06 Q15654
PDB IDs		1OA8 4APT 4AQP 4J2J 4J2L	1X61 2DLO
Enriched GO Terms of Interacting Partners?		Gene Expression RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Biosynthetic Process Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Organic Substance Multicellular Organismal Development Positive Regulation Of Metabolic Process Developmental Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Differentiation System Development Anatomical Structure Development Cell Differentiation Organ Development Positive Regulation Of Protein Metabolic Process Positive Regulation Of Gene Expression Cellular Response To Organic Substance Cellular Process Response To Stress Positive Regulation Of Cellular Protein Metabolic Process Generation Of Neurons Response To Stimulus	Signal Complex Assembly Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Response To Organic Substance Regulation Of Signaling Actin Filament-based Process Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Positive Regulation Of Intracellular Signal Transduction Response To Growth Factor Cytoskeleton Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction ERBB Signaling Pathway Cell Communication Cellular Process Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorylation Multicellular Organismal Development Regulation Of Apoptotic Process Response To Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Response To Transforming Growth Factor Beta Regulation Of Protein Phosphorylation Cellular Response To Stimulus Platelet Activation Response To Hormone Response To Stress Cellular Response To Growth Factor Stimulus Response To Wounding Regulation Of Protein Metabolic Process Regulation Of Cell Death Actin Cytoskeleton Organization Wound Healing Signaling Transforming Growth Factor Beta Receptor Signaling Pathway Organ Development Regulation Of Cell Motility Cell Motility Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Apoptotic Process
Tagcloud ?		akap6 atf7 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668	adaptors ap competition dimerization discrete domains enables enhances example exerts focal glucocorticoid gr interacts intriguing isoform lim med1 mediating mediator negatively orchestrating promoters recruitment tethering thought thrap3 transrepression
Tagcloud (Difference) ?		akap6 atf7 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668	adaptors ap competition dimerization discrete domains enables enhances example exerts focal glucocorticoid gr interacts intriguing isoform lim med1 mediating mediator negatively orchestrating promoters recruitment tethering thought thrap3 transrepression
Tagcloud (Intersection) ?