| Description | ataxin 1 | ataxin 2 | 
    
      | Image |  |  | 
    
 
     | Cellular Component |  |  | 
    
      | Molecular Function |  |  | 
    
      | Biological Process |  |  | 
    
      | Pathways |  |  | 
    
      | Drugs |  |  | 
    
      | Diseases |  |  | 
    
      | GWAS | 
                          Amyotrophic lateral sclerosis ( 19451621)Atrial fibrillation ( 30061737 29892015)Breast cancer ( 29059683)Central corneal thickness ( 32528159)Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444)Cortical amyloid beta load ( 29860282)Fish- and plant-related diet ( 32066663)Gambling ( 22780124)General cognitive ability ( 29844566)Generalized epilepsy ( 30531953)Granulocyte count ( 27863252)Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)Gut microbiota relative abundance (Ruminococcus belonging to family Lachnospiraceae) ( 33208821)HDL cholesterol levels ( 32203549)High light scatter reticulocyte count ( 27863252)High light scatter reticulocyte percentage of red cells ( 27863252)Household income (MTAG) ( 31844048)Immature fraction of reticulocytes ( 32888494)Lymphocyte percentage of white cells ( 32888494)Major depressive disorder ( 23377640)Metabolite levels ( 23823483)Monocyte count ( 32888494)Monocyte percentage of white cells ( 32888494)Multiple sclerosis ( 31604244)Myeloid white cell count ( 27863252)Neutrophil count ( 27863252 32888494 29403010)Neutrophil percentage of white cells ( 32888494)Reticulocyte count ( 27863252)Reticulocyte fraction of red cells ( 27863252)Subcutaneous adipose tissue attenuation (Hounsfield unit scale) ( 27918534)Sum basophil neutrophil counts ( 27863252)Sum neutrophil eosinophil counts ( 27863252)Systemic lupus erythematosus ( 27399966 28714469)Total body bone mineral density ( 30172743)Visceral adipose tissue attenuation (Hounslow unit scale) ( 27918534)Waist circumference adjusted for body mass index ( 34021172)White blood cell count ( 29403010 27863252 32888494) | 
                          Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081)Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359)Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359)Allergic disease (asthma, hay fever or eczema) ( 29083406)Allergic rhinitis ( 30013184 31361310)Alopecia areata ( 25608926)Apolipoprotein B levels ( 32203549)Arthritis (juvenile idiopathic) ( 33106285)Asthma ( 30929738 32296059)Asthma (age of onset) ( 31036433)Asthma (childhood onset) ( 30929738 31036433)Asthma onset (childhood vs adult) ( 30929738)Beta-2 microglubulin plasma levels ( 23417110)Blood osmolality (transformed sodium) ( 28360221)Blood pressure ( 21909110)Body mass index ( 26426971)Body mass index and coronary artery disease (pairwise) ( 33619380)Body mass index and HDL-C (pairwise) ( 33619380)Body mass index and systole blood pressure (pairwise) ( 33619380)Caffeine consumption from coffee or tea ( 33287642)Celiac disease ( 18311140 22057235)Chronic kidney disease ( 20383146)Coronary artery disease ( 29212778)Crohn's disease ( 26192919 28067908)Diastolic blood pressure ( 19430483 26390057 27736895)Diastolic blood pressure (cigarette smoking interaction) ( 29455858)Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)Eosinophil count ( 27863252 32888494)Eosinophil percentage of granulocytes ( 27863252)Eosinophil percentage of white cells ( 27863252 32888494)Estimated glomerular filtration rate ( 31015462 31152163)Gastroesophageal reflux disease ( 31527586)Glaucoma (primary open-angle) ( 26752265 33627673)Glomerular filtration rate (cystatin C) ( 28452372)Glycated hemoglobin levels ( 28898252)HDL cholesterol ( 30275531)Heart failure ( 31919418)Hematocrit ( 19862010)High light scatter reticulocyte count ( 27863252)High light scatter reticulocyte percentage of red cells ( 27863252)Hypertension ( 31879980)Hypothyroidism ( 22493691 27182965)Immature fraction of reticulocytes ( 27863252)Inflammatory bowel disease ( 26192919 28067908)Intraocular pressure ( 30054594)Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761)LDL cholesterol ( 30275531)LDL cholesterol levels ( 32203549)Left ventricle diastolic internal dimension ( 28394258)Liver enzyme levels (alkaline phosphatase) ( 33972514)Low density lipoprotein cholesterol levels ( 32154731)Lymphocyte percentage of white cells ( 32888494)Mean arterial pressure ( 27618448)Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962)Mean corpuscular hemoglobin ( 32888494)Mean corpuscular volume ( 27863252 32888494)Mean platelet volume ( 32888494)Mean reticulocyte volume ( 32888494)Mean spheric corpuscular volume ( 32888494)Monocyte count ( 27863252)Myeloproliferative neoplasms ( 33057200)Myocardial infarction ( 30226566 33532862)Neutrophil count ( 32888494)Neutrophil percentage of granulocytes ( 27863252)Neutrophil percentage of white cells ( 32888494)Parental lifespan ( 30642433)Parental longevity (combined parental age at death) ( 29227965)Parental longevity (combined parental attained age, Martingale residuals) ( 29227965)Parental longevity (father's age at death) ( 29227965)Parental longevity (father's attained age) ( 29227965)Parental longevity (mother's attained age) ( 29227965)Peripheral artery disease ( 25009551)Platelet count ( 24026423 27863252 29403010 32888494 33545615)Platelet distribution width ( 27863252)Plateletcrit ( 27863252 32888494)Primary biliary cholangitis ( 26394269)Primary biliary cirrhosis ( 22961000)Primary sclerosing cholangitis ( 23603763)Reaction time ( 29844566)Red blood cell count ( 32888494)Red blood cell traits ( 23222517)Reticulocyte fraction of red cells ( 27863252)Retinal vascular caliber ( 21060863)Sarcoidosis ( 26051272)Serum alkaline phosphatase levels ( 33547301)Serum total protein levels ( 29403010)Sjögren's syndrome ( 24097067)Smoking initiation ( 33082346)Smoking initiation (ever regular vs never regular) ( 30679032)Smoking status (ever vs never smokers) ( 30643258)Sum eosinophil basophil counts ( 27863252)Systemic lupus erythematosus ( 26502338 28714469 33272962)Systolic blood pressure (cigarette smoking interaction) ( 29455858)Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)Thyroid peroxidase antibody levels ( 24586183)Thyroid peroxidase antibody positivity ( 24586183)Total cholesterol levels ( 30275531)Urate levels ( 23263486 31578528)Vitiligo ( 27723757)White blood cell count ( 32888494) | 
    
	
    
				
    
      | Interacting Genes | 289 interacting genes:
                  -
                  ACACA
                  ACOT7
                  ADAM15
                  ADCY6
                  ADD3
                  AHDC1
                  AKT1
                  ANKHD1
                  ANP32A
                  APBB1
                  ARHGAP32
                  ARID5A
                  ASNS
                  ATF5
                  ATP1A3
                  ATP6V0D1
                  ATXN1L
                  ATXN2
                  ATXN2L
                  BAALC
                  BASP1
                  BATF2
                  BEND2
                  BHLHE40
                  BICRAL
                  BLTP3B
                  BRD10
                  BTG3
                  C10orf55
                  C1orf94
                  CAMK1
                  CAMK2B
                  CCDC136
                  CCNK
                  CDIP1
                  CDK6
                  CDRT15P3
                  CFL1
                  CHRNA7
                  CIC
                  CIRBP
                  CLASRP
                  CLCN2
                  CLEC4F
                  COIL
                  CPSF7
                  CREM
                  CRIP2
                  CRK
                  CRX
                  CRY2
                  CST3
                  CUTC
                  DAZ2
                  DAZAP2
                  DCTN3
                  DHRSX
                  DHX37
                  DIXDC1
                  DMPK
                  DNAJA3
                  DOCK5
                  DZIP3
                  EFEMP2
                  EHMT1
                  EIF1AY
                  EIF1B
                  EIF3F
                  EIF4ENIF1
                  ELP5
                  EML3
                  ENTPD6
                  EPN2
                  ESRP1
                  ESRRA
                  ETV4
                  EXTL3
                  FAM153B
                  FAM168A
                  FAM193B
                  FAR1
                  FAT4
                  FDPS
                  FHL2
                  FNDC9
                  FOSL1
                  FOXN4
                  FUBP3
                  FYN
                  GAPDH
                  GATAD1
                  GCA
                  GCFC2
                  GGA2
                  GMEB2
                  GPATCH8
                  GSPT1
                  H2AP
                  H3C1
                  HACL2
                  HEY2
                  HEYL
                  HIVEP1
                  HNRNPLL
                  HOTAIR
                  HPCAL1
                  HSFX1
                  HSFY1
                  HSFY2
                  HSPA1A
                  IGF2R
                  IL34
                  IMMT
                  IPO8
                  IST1
                  ITGB4
                  KAT5
                  KAT6A
                  KCNAB2
                  KCTD15
                  KIAA1549L
                  KIF22
                  KLF11
                  KLHL12
                  KLHL8
                  KMT2B
                  KRTAP12-4
                  KRTAP13-3
                  LASP1
                  LDB1
                  LITAF
                  LOXL1
                  LPAR2
                  LRSAM1
                  MAGEB18
                  MAGEB2
                  MAGEB6
                  MATN2
                  MBP
                  MED15
                  METTL17
                  METTL27
                  MLST8
                  MSMO1
                  MSX2
                  MTERF4
                  MYO18A
                  NARS1
                  NCAM1
                  NCOR1
                  NCOR2
                  NFYA
                  NHSL2
                  NLGN3
                  NLK
                  NPHP3
                  NR4A1
                  NUDT21
                  NUMBL
                  NUTM2B
                  OAZ1
                  OPCML
                  OTX2
                  PANX2
                  PEPD
                  PHPT1
                  PIAS1
                  PICALM
                  PIM2
                  PLA2G10
                  PLEKHB1
                  PLEKHN1
                  PML
                  POGZ
                  POM121
                  POMP
                  PPAT
                  PPP6R2
                  PQBP1
                  PRDM1
                  PRR20A
                  PRR20B
                  PRR20C
                  PRR20D
                  PRR20E
                  PRRC2A
                  PRRC2B
                  PSMC3
                  PSPH
                  PTGDS
                  PUM1
                  QKI
                  QRICH1
                  R3HDM1
                  R3HDM2
                  RAD54L2
                  RAI2
                  RAPGEF1
                  RAPGEF4
                  RBFOX1
                  RBFOX2
                  RBM26
                  RBPMS
                  RCC1L
                  RCN1
                  REL
                  RHOXF2
                  RNF10
                  RNF31
                  RNF4
                  SAR1A
                  SEMA4G
                  SETD2
                  SETD6
                  SF1
                  SGMS1
                  SIX5
                  SLC25A51
                  SLC4A2
                  SLC51A
                  SLC6A13
                  SMARCC2
                  SORCS3
                  SOX3
                  SPEN
                  SREBF1
                  SREBF2
                  ST6GALNAC6
                  STAC2
                  STAM2
                  SUGP2
                  SUMO1
                  SUPT20H
                  SV2A
                  SYBU
                  TBC1D5
                  TBX15
                  TCAP
                  TCEANC
                  TCTA
                  TDP2
                  TENT5A
                  TENT5B
                  TMX2
                  TOLLIP
                  TOMM20
                  TOX4
                  TP53I11
                  TPRX1
                  TRAF2
                  TRIM32
                  TRIM38
                  TRIP6
                  TSC1
                  TTC19
                  U2AF2
                  UBAP2L
                  UBE2E3
                  UBE2I
                  UBQLN4
                  UHRF2
                  UNK
                  USP54
                  USP7
                  VCP
                  VSNL1
                  VSTM2L
                  WASHC2C
                  WNK1
                  WNK2
                  YWHAE
                  YWHAZ
                  YY1AP1
                  ZBTB32
                  ZC3H10
                  ZC3H7B
                  ZCCHC13
                  ZHX1
                  ZHX2
                  ZHX3
                  ZNF276
                  ZNF488
                  ZNF609
                  ZNF804A
                  ZSCAN1
                  ZSWIM8
                  ZXDC
                  ZYX | 23 interacting genes:
                  ACTN1
                  ACTN2
                  ATXN1
                  BAG6
                  BIN1
                  CEBPA
                  CHGB
                  GFI1B
                  GOLGA6L5P
                  IDH3B
                  KIFBP
                  LCP1
                  MIR128-1
                  MIR34B
                  MIR7-1
                  NCOA4
                  PABPC1
                  PLS3
                  POLR1H
                  RBFOX1
                  SH3GL2
                  SH3GL3
                  TDRD7 | 
				
    
      | Entrez ID | 6310 | 6311 | 
    
      | HPRD ID | 03333 | 03307 | 
    
      | Ensembl ID | ENSG00000124788 | ENSG00000204842 | 
    
      | Uniprot IDs | A0A2R8YCF3 
                P54253 
                Q96FF1 | A0A5F9ZI57 
                F8VQP2 
                Q2M2R5 
                Q99700 
                V9GY86 | 
    
      | PDB IDs | 1OA8 
                    2M41 
                    4APT 
                    4AQP 
                    4J2J 
                    4J2L 
                    6QIU | 3KTR | 
    
      | Enriched GO Terms of Interacting Partners? |  |  | 
    
      | Tagcloud ? |  |  | 
    
      | Tagcloud (Difference) ? |  |  | 
    
      | Tagcloud (Intersection) ? |  |