ATXN1 and UBE2I

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ATXN1	UBE2I
Gene Name		ataxin 1	ubiquitin-conjugating enzyme E2I
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear RNA Export Factor Complex Nuclear Inclusion Body Intracellular Membrane-bounded Organelle	Synaptonemal Complex Fibrillar Center Nucleus Nucleoplasm Cytoplasm PML Body Dendrite Synapse Transferase Complex Sumoylated E2 Ligase Complex
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Protein C-terminus Binding Poly(U) RNA Binding Poly(G) Binding Identical Protein Binding Protein Self-association	Protein Binding ATP Binding Protein C-terminus Binding Transcription Factor Binding Ligase Activity Enzyme Binding Ubiquitin Protein Ligase Binding HLH Domain Binding BHLH Transcription Factor Binding Poly(A) RNA Binding Ubiquitin Protein Ligase Activity SUMO Conjugating Enzyme Activity RING-like Zinc Finger Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Processing Adult Locomotory Behavior Visual Learning Negative Regulation Of Phosphorylation Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Lung Alveolus Development Nuclear Export Regulation Of Excitatory Postsynaptic Membrane Potential	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Chromosome Segregation Mitotic Nuclear Division Regulation Of Receptor Activity Viral Process Protein Ubiquitination Protein Sumoylation Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cell Division Positive Regulation Of SUMO Transferase Activity
Pathways			Post-translational protein modification SUMOylation Meiotic synapsis Processing and activation of SUMO SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 19451621) Gambling ( 22780124) Major depressive disorder ( 23377640)
Protein-Protein Interactions		252 interactors: ACACA ACOT7 ADCY6 ADD3 AHDC1 AKT1 ANKHD1 ANP32A APBB1 ARHGAP32 ARID5A ASNS ATF5 ATP1A3 ATP6V0D1 ATXN1L ATXN2 ATXN2L BAALC BASP1 BATF2 BEND2 BTG3 C1orf94 C2orf27B CAMK2B CCDC136 CCNK CDIP1 CDK6 CFL1 CHRNA7 CIC CIRBP CLASRP CLCN2 CLEC4F COIL CPSF7 CREM CRIP2 CRK CRY2 CST3 DAZAP2 DCTN3 DHRSX DHX37 DIXDC1 DMPK DNAJA3 DOCK5 DZIP3 EFEMP2 EHMT1 EIF1AY EIF1B EIF3F EIF4ENIF1 ELP5 ENTPD6 ESRP1 ESRRA ETV4 FAM193B FAM21C FAM46A FAM46B FAR1 FAT4 FDPS FHL2 FOSL1 FUBP3 FYN GAPDH GATAD1 GCA GCFC2 GGA2 GMEB2 GPATCH8 GSPT1 HEY2 HEYL HIST1H3A HIVEP1 HNRNPLL HOTAIR HPCAL1 HSFX1 HSPA1A HYPM IGF2R IL34 ILVBL IMMT IPO8 IST1 ITGB4 KAT5 KAT6A KCNAB2 KCTD15 KIAA1549L KIAA2026 KIF22 KLF11 KLHL12 KLHL8 KMT2B LASP1 LDB1 LITAF LOC401442 LOXL1 LPAR2 LRSAM1 MAGEB18 MAGEB2 MAGEB6 MATN2 MBP MED15 METTL17 MLST8 MSMO1 MSX2 MTERF4 MYO18A NARS NCAM1 NCOR1 NCOR2 NLK NPHP3 NR4A1 NUDT21 NUMBL NUTM2B OAZ1 OPCML OTX2 PEPD PHPT1 PIAS1 PIM2 PLEKHB1 PML POM121 PPAT PPP6R2 PQBP1 PRDM1 PRR20A PRRC2A PRRC2B PSMC3 PSPH PTGDS PUM1 QKI QRICH1 R3HDM1 R3HDM2 RAD54L2 RAI2 RAPGEF1 RAPGEF4 RBFOX1 RBFOX2 RBM26 RBPMS RCN1 REL RHOXF2 RNF31 RNF4 SAR1A SEMA4G SETD2 SF1 SGMS1 SIX5 SLC25A51 SLC4A2 SLC51A SLC6A13 SMARCC2 SPEN SREBF1 SREBF2 ST6GALNAC6 STAC2 STAM2 SUGP2 SUMO1 SUMO2 SUPT20H SV2A SYBU TBC1D5 TBX15 TCAP TCEANC TCTA TDP2 TMX2 TOLLIP TOMM20 TOX4 TP53I11 TRAF2 TRIM32 TRIM38 TRIP6 TSC1 TTC19 U2AF2 UBAP2L UBE2E3 UBE2I UBQLN4 UHRF1BP1L UHRF2 UNK USP54 USP7 VCP VSNL1 VSTM2L WBSCR16 WNK1 WNK2 YWHAE YWHAZ YY1AP1 ZBTB32 ZC3H10 ZC3H7B ZCCHC13 ZHX1 ZHX2 ZHX3 ZNF276 ZNF488 ZNF609 ZNF804A ZSCAN1 ZSWIM8 ZXDC ZYX	258 interactors: ADAR ANXA1 APEX1 AR ARNT ARNTL ATF2 ATF7IP ATXN1 BCAM BEND5 BIRC3 BIRC7 BLM BLMH BMI1 C18orf25 CARM1 CASP2 CASP8AP2 CBLC CBS CBX4 CDC37 CDCA8 CEBPD CEBPE CFTR CHD3 CHFR CHMP1A CHMP4B CHUK CLDN2 CLK2 CORO2A CREB1 CREBBP CREM CSNK2B CTBP2 DACH1 DAXX DES DHX9 DNM1 DNMT3A DNMT3B DRG1 DTX3L DZIP3 EDARADD EDF1 EGR2 ELK1 EP300 ESR1 ETS1 ETV6 EXOSC9 FAS FHIT FHL3 FLI1 FMR1 FOS FOXM1 GCM1 GLUL GMCL1P1 GMEB1 GMEB2 GOLGA2 GOLGB1 GRIP1 HABP4 HDAC1 HDAC4 HDAC5 HDAC7 HGS HIC1 HIPK1 HIPK2 HIPK3 HIST1H4A HIST4H4 HMGN2 HNF4A HNRNPC HNRNPD HNRNPK HNRNPLL HSF1 HSF2 HSF2BP IKZF1 IKZF3 IPO13 JUN KCNK1 KCTD1 KLHL12 KRT19 LMNA LMO2 LNX2 MAP3K1 MAPK1IP1L MARCH5 MDM2 MED7 MGRN1 MITF MKL1 MKRN3 MTA1 MYB NCOR2 NIN NR1D2 NR1H2 NR3C1 NR3C2 NR5A2 NUDCD3 PARK7 PARP1 PDLIM7 PDZK1 PELI1 PEX10 PHC1 PIAS1 PIAS2 PIAS3 PIAS4 PLAGL1 PML PPARA PPARGC1A PPM1J PRKAA2 PRPF40A PSMC3 PTEN PUF60 RAD18 RAD51 RAD52 RAD54B RAD54L2 RANBP2 RANGAP1 RB1 RBBP5 RBBP6 RC3H2 RCBTB2 RFPL3 RIPK2 RNF10 RNF111 RNF115 RNF128 RNF133 RNF144B RNF185 RNF4 RNF40 RORB RPS6KA6 SAE1 SALL1 SATB1 SCNN1A SETBP1 SETD8 SETDB1 SETX SIAH1 SIAH2 SIRT1 SKIL SLC2A1 SLC2A4 SMAD4 SNIP1 SOCS6 SOX10 SOX4 SP100 SP3 SPECC1L SREBF1 SREBF2 SRF STAT1 STRA13 SUMO1 SUMO1P1 SUMO2 SUMO3 SUZ12 TAB2 TAF1 TAF10 TAF12 TAF5 TBP TCF3 TCF7L2 TDG TDP2 TFAP2A TFAP2B TFAP2C TNFRSF1A TOP1 TOPORS TP53 TP63 TP73 TRAF3 TRAF4 TRAF6 TRIM21 TRIM23 TRIM27 TRIM28 TRIM29 TRIM38 TRIM41 TRIM54 TRIM63 TRIM72 TRPS1 UBA2 UBE2K UBXN1 UCHL1 UNC119 USP25 WHSC1L1 WT1 XBP1 XIAP ZBED1 ZBTB16 ZBTB26 ZBTB8A ZCCHC7 ZEB2 ZMYM2 ZNF106 ZNF451 ZNF646 ZNRD1
Entrez ID		6310	7329
HPRD ID		03333	09045
Ensembl ID		ENSG00000124788	ENSG00000103275
Uniprot IDs		P54253 Q96FF1	A8K503 B0QYN7 P63279
PDB IDs		1OA8 4APT 4AQP 4J2J 4J2L	1A3S 1KPS 1Z5Q 1Z5S 2GRN 2GRO 2GRP 2GRQ 2GRR 2O25 2PE6 2PX9 2XWU 3A4S 3UIN 3UIO 3UIP
Enriched GO Terms of Interacting Partners?		Gene Expression RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Biosynthetic Process Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Organic Substance Multicellular Organismal Development Positive Regulation Of Metabolic Process Developmental Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Differentiation System Development Anatomical Structure Development Cell Differentiation Organ Development Positive Regulation Of Protein Metabolic Process Positive Regulation Of Gene Expression Cellular Response To Organic Substance Cellular Process Response To Stress Positive Regulation Of Cellular Protein Metabolic Process Generation Of Neurons Response To Stimulus	Transcription, DNA-templated RNA Biosynthetic Process Gene Expression RNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Regulation Of Cellular Process Protein Ubiquitination Chromosome Organization Response To Organic Substance Metabolic Process Cellular Protein Modification Process Cellular Response To Stress Chromatin Organization Chromatin Modification Peptidyl-lysine Modification Cellular Response To Organic Substance Regulation Of Protein Metabolic Process Cellular Response To Stimulus
Tagcloud ?		akap6 atf7 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668	array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2e1 ube2n ube2q1 ube2z ubiquitin ubiquitination
Tagcloud (Difference) ?		akap6 atf7 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668	array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2e1 ube2n ube2q1 ube2z ubiquitin ubiquitination
Tagcloud (Intersection) ?