ATXN1 and FDPS

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ATXN1	FDPS
Gene Name		ataxin 1	farnesyl diphosphate synthase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear RNA Export Factor Complex Nuclear Inclusion Body Intracellular Membrane-bounded Organelle	Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Protein C-terminus Binding Poly(U) RNA Binding Poly(G) Binding Identical Protein Binding Protein Self-association	Dimethylallyltranstransferase Activity Geranyltranstransferase Activity Poly(A) RNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Processing Adult Locomotory Behavior Visual Learning Negative Regulation Of Phosphorylation Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Lung Alveolus Development Nuclear Export Regulation Of Excitatory Postsynaptic Membrane Potential	Cholesterol Biosynthetic Process Viral Process Geranyl Diphosphate Biosynthetic Process Small Molecule Metabolic Process Farnesyl Diphosphate Biosynthetic Process
Pathways			Regulation of cholesterol biosynthesis by SREBP (SREBF) Cholesterol biosynthesis Metabolism of lipids and lipoproteins Activation of gene expression by SREBF (SREBP)
Drugs			Pamidronate Zoledronate Alendronate Ibandronate Risedronate Dimethylallyl Diphosphate Isopentyl Pyrophosphate Geranyl Diphosphate ISOPENTENYL PYROPHOSPHATE FARNESYL DIPHOSPHATE GERANYLGERANYL DIPHOSPHATE
Diseases
GWAS		Amyotrophic lateral sclerosis ( 19451621) Gambling ( 22780124) Major depressive disorder ( 23377640)
Protein-Protein Interactions		252 interactors: ACACA ACOT7 ADCY6 ADD3 AHDC1 AKT1 ANKHD1 ANP32A APBB1 ARHGAP32 ARID5A ASNS ATF5 ATP1A3 ATP6V0D1 ATXN1L ATXN2 ATXN2L BAALC BASP1 BATF2 BEND2 BTG3 C1orf94 C2orf27B CAMK2B CCDC136 CCNK CDIP1 CDK6 CFL1 CHRNA7 CIC CIRBP CLASRP CLCN2 CLEC4F COIL CPSF7 CREM CRIP2 CRK CRY2 CST3 DAZAP2 DCTN3 DHRSX DHX37 DIXDC1 DMPK DNAJA3 DOCK5 DZIP3 EFEMP2 EHMT1 EIF1AY EIF1B EIF3F EIF4ENIF1 ELP5 ENTPD6 ESRP1 ESRRA ETV4 FAM193B FAM21C FAM46A FAM46B FAR1 FAT4 FDPS FHL2 FOSL1 FUBP3 FYN GAPDH GATAD1 GCA GCFC2 GGA2 GMEB2 GPATCH8 GSPT1 HEY2 HEYL HIST1H3A HIVEP1 HNRNPLL HOTAIR HPCAL1 HSFX1 HSPA1A HYPM IGF2R IL34 ILVBL IMMT IPO8 IST1 ITGB4 KAT5 KAT6A KCNAB2 KCTD15 KIAA1549L KIAA2026 KIF22 KLF11 KLHL12 KLHL8 KMT2B LASP1 LDB1 LITAF LOC401442 LOXL1 LPAR2 LRSAM1 MAGEB18 MAGEB2 MAGEB6 MATN2 MBP MED15 METTL17 MLST8 MSMO1 MSX2 MTERF4 MYO18A NARS NCAM1 NCOR1 NCOR2 NLK NPHP3 NR4A1 NUDT21 NUMBL NUTM2B OAZ1 OPCML OTX2 PEPD PHPT1 PIAS1 PIM2 PLEKHB1 PML POM121 PPAT PPP6R2 PQBP1 PRDM1 PRR20A PRRC2A PRRC2B PSMC3 PSPH PTGDS PUM1 QKI QRICH1 R3HDM1 R3HDM2 RAD54L2 RAI2 RAPGEF1 RAPGEF4 RBFOX1 RBFOX2 RBM26 RBPMS RCN1 REL RHOXF2 RNF31 RNF4 SAR1A SEMA4G SETD2 SF1 SGMS1 SIX5 SLC25A51 SLC4A2 SLC51A SLC6A13 SMARCC2 SPEN SREBF1 SREBF2 ST6GALNAC6 STAC2 STAM2 SUGP2 SUMO1 SUMO2 SUPT20H SV2A SYBU TBC1D5 TBX15 TCAP TCEANC TCTA TDP2 TMX2 TOLLIP TOMM20 TOX4 TP53I11 TRAF2 TRIM32 TRIM38 TRIP6 TSC1 TTC19 U2AF2 UBAP2L UBE2E3 UBE2I UBQLN4 UHRF1BP1L UHRF2 UNK USP54 USP7 VCP VSNL1 VSTM2L WBSCR16 WNK1 WNK2 YWHAE YWHAZ YY1AP1 ZBTB32 ZC3H10 ZC3H7B ZCCHC13 ZHX1 ZHX2 ZHX3 ZNF276 ZNF488 ZNF609 ZNF804A ZSCAN1 ZSWIM8 ZXDC ZYX	3 interactors: ATXN1 EIF4ENIF1 FGFR1
Entrez ID		6310	2224
HPRD ID		03333	00606
Ensembl ID		ENSG00000124788	ENSG00000160752
Uniprot IDs		P54253 Q96FF1	P14324
PDB IDs		1OA8 4APT 4AQP 4J2J 4J2L	1YQ7 1YV5 1ZW5 2F7M 2F89 2F8C 2F8Z 2F92 2F94 2F9K 2OPM 2OPN 2QIS 2RAH 2VF6 3B7L 3CP6 3N1V 3N1W 3N3L 3N45 3N46 3N49 3N5H 3N5J 3N6K 3RYE 3S4J 4DEM 4GA3 4H5C 4H5D 4H5E
Enriched GO Terms of Interacting Partners?		Gene Expression RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Biosynthetic Process Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Organic Substance Multicellular Organismal Development Positive Regulation Of Metabolic Process Developmental Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Differentiation System Development Anatomical Structure Development Cell Differentiation Organ Development Positive Regulation Of Protein Metabolic Process Positive Regulation Of Gene Expression Cellular Response To Organic Substance Cellular Process Response To Stress Positive Regulation Of Cellular Protein Metabolic Process Generation Of Neurons Response To Stimulus	Regulation Of Lateral Mesodermal Cell Fate Specification Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Lung Development Respiratory Tube Development Ventricular Zone Neuroblast Division Respiratory System Development Orbitofrontal Cortex Development Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Outer Ear Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Mesenchymal-epithelial Cell Signaling Forebrain Neuroblast Division Regulation Of Branching Involved In Salivary Gland Morphogenesis Auditory Receptor Cell Development Lung-associated Mesenchyme Development Regulation Of Cell Fate Specification Tube Development Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Paraxial Mesoderm Development Middle Ear Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter Somatic Stem Cell Division Positive Regulation Of Cardiac Muscle Cell Proliferation Branching Involved In Salivary Gland Morphogenesis Auditory Receptor Cell Differentiation Regulation Of Cell Fate Commitment Cell-cell Signaling Regulation Of Gastrulation Organ Induction Hair Cell Differentiation Positive Regulation Of Heart Growth Inner Ear Receptor Cell Development Positive Regulation Of Mesenchymal Cell Proliferation Stem Cell Division Regulation Of Cardiac Muscle Cell Proliferation Salivary Gland Morphogenesis Salivary Gland Development Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Organ Growth Cell Proliferation In Forebrain Negative Regulation Of Transcription, DNA-templated Developmental Induction Regulation Of Organ Formation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Lung Alveolus Development Neuroblast Proliferation Neurological System Process
Tagcloud ?		akap6 atf7 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668	clopidogrel clots corresponds dissolution elt euglobulin extrinsic fgfc1 fibrin fibrinogen fibrinogenolysis fibrinolytic fitc fluorescein hemolytic hemorrhagic isothiocyanate lysis ogen olytic pharmacodynamic pyranoindole shortened stems thromboembolism thrombolysis thrombolytic thrombus urokinase
Tagcloud (Difference) ?		akap6 atf7 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668	clopidogrel clots corresponds dissolution elt euglobulin extrinsic fgfc1 fibrin fibrinogen fibrinogenolysis fibrinolytic fitc fluorescein hemolytic hemorrhagic isothiocyanate lysis ogen olytic pharmacodynamic pyranoindole shortened stems thromboembolism thrombolysis thrombolytic thrombus urokinase
Tagcloud (Intersection) ?