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HSPA8 and HGS
Number of citations of the paper that reports this interaction (PubMedID
33961781
)
97
Data Source:
BioGRID
(affinity chromatography technology, pull down)
HSPA8
HGS
Description
heat shock protein family A (Hsp70) member 8
hepatocyte growth factor-regulated tyrosine kinase substrate
Image
GO Annotations
Cellular Component
Prp19 Complex
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Spliceosomal Complex
Nucleolus
Cytoplasm
Lysosome
Lysosomal Membrane
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Secretory Granule Lumen
Melanosome
Lysosomal Lumen
Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane
Extracellular Exosome
Blood Microparticle
Lumenal Side Of Lysosomal Membrane
Protein Folding Chaperone Complex
Ficolin-1-rich Granule Lumen
Ribonucleoprotein Complex
Cytoplasm
Lysosome
Endosome
Early Endosome
Cytosol
Membrane
Early Endosome Membrane
Multivesicular Body Membrane
ESCRT-0 Complex
Extracellular Exosome
Phagocytic Vesicle Lumen
Molecular Function
Nucleotide Binding
G Protein-coupled Receptor Binding
RNA Binding
Protein Binding
ATP Binding
Hydrolase Activity
ATP Hydrolysis Activity
Enzyme Binding
MHC Class II Protein Complex Binding
Protein-macromolecule Adaptor Activity
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Protein Folding Chaperone
Cadherin Binding
Receptor Ligand Activity
Unfolded Protein Binding
Protein-folding Chaperone Binding
C3HC4-type RING Finger Domain Binding
ATP-dependent Protein Disaggregase Activity
ATP-dependent Protein Folding Chaperone
Protein Binding
Zinc Ion Binding
Protein Domain Specific Binding
Phosphatidylinositol Binding
Ubiquitin Binding
Ubiquitin-like Protein Ligase Binding
Metal Ion Binding
Biological Process
MRNA Splicing, Via Spliceosome
MRNA Processing
Protein Folding
Autophagy
Response To Unfolded Protein
Signal Transduction
RNA Splicing
Cellular Response To Starvation
Negative Regulation Of Signal Transduction
Protein Catabolic Process
Positive Regulation Of Cell Migration
Regulation Of Protein Stability
Cellular Response To Stress
Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Protein Refolding
Regulation Of Protein-containing Complex Assembly
Negative Regulation Of DNA-templated Transcription
ATP Metabolic Process
Negative Regulation Of Cellular Component Organization
Membrane Organization
Regulation Of Protein Complex Stability
Chaperone-mediated Autophagy
Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy
Cellular Response To Steroid Hormone Stimulus
Clathrin Coat Disassembly
Negative Regulation Of NLRP3 Inflammasome Complex Assembly
Regulation Of Supramolecular Fiber Organization
Negative Regulation Of Supramolecular Fiber Organization
Regulation Of Protein Import
Chaperone-mediated Autophagy Translocation Complex Disassembly
Protein Targeting To Lysosome
Signal Transduction
Negative Regulation Of Cell Population Proliferation
Membrane Invagination
Positive Regulation Of Gene Expression
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Protein Transport
Endosomal Transport
Macroautophagy
Negative Regulation Of Angiogenesis
Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Receptor Internalization
Endocytic Recycling
Multivesicular Body Assembly
Regulation Of Protein Catabolic Process
Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Regulation Of MAP Kinase Activity
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Protein Localization To Membrane
Membrane Fission
Positive Regulation Of Exosomal Secretion
Pathways
Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Attenuation phase
HSF1-dependent transactivation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
CHL1 interactions
AUF1 (hnRNP D0) binds and destabilizes mRNA
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
mRNA Splicing - Major Pathway
Clathrin-mediated endocytosis
Protein methylation
GABA synthesis, release, reuptake and degradation
Lipophagy
Chaperone Mediated Autophagy
Late endosomal microautophagy
Respiratory syncytial virus genome transcription
PKR-mediated signaling
EGFR downregulation
Lysosome Vesicle Biogenesis
Ub-specific processing proteases
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
InlB-mediated entry of Listeria monocytogenes into host cell
RHOU GTPase cycle
Endosomal Sorting Complex Required For Transport (ESCRT)
Inhibition of membrane repair
Prevention of phagosomal-lysosomal fusion
RHOBTB3 ATPase cycle
Drugs
Dasatinib
(2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Copper
Artenimol
Citric acid
Diseases
GWAS
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular hemoglobin concentration (
29403010
32888494
)
Postoperative acute renal failure after cardiac surgery (
30678657
)
Red cell distribution width (
32888494
)
Serum metabolite levels (
33031748
)
Eye color traits (
20463881
)
Refractive error (
32231278
)
Interacting Genes
92 interacting genes:
ABI1
AIPL1
ALDOB
APOB
ATM
BAG1
BAG2
BAG3
BAG4
BAG6
BRCA1
CCT3
CD40
CDKN2A
CITED1
CLTA
COL7A1
CXCR4
CYCS
DNAJA1
DNAJA3
DPP3
DYNLL1
EGFR
ERBB3
ERH
ESR1
FANCC
FBP1
FNDC3B
FOXP1
GAK
GCH1
GOT2
H3C1
HDAC10
HDAC3
HGS
HLTF
HSF1
HSP90AA1
HSPA1A
HSPBP1
HSPH1
HTN3
HTT
IL32
JAK2
JUN
LALBA
LINC01554
MAPK8
MAPT
NEDD8
NMI
NOA1
PHC1
PPID
PTEN
PTPRF
RAF1
RB1
REL
RGS2
RNF26
SAYSD1
SIRPA
SNCA
SP1
SRRT
ST13
STAT1
STIP1
STMN1
STUB1
SUMO2
SUMO4
TADA3
TCERG1
TGM2
TM4SF1
TNFRSF1A
TRIM38
TSSK6
TTC1
UBC
UCHL1
USP40
VHL
WEE2-AS1
YWHAG
YWHAQ
328 interacting genes:
ABI2
ACLY
ACOT11
ACTN3
ADRA2C
AHCYL1
AKAP8L
ANKRD55
ANTKMT
APC
APLP2
APP
ARFIP2
ARL6IP1
ARMC7
ASB12
ATN1
ATP1A1
ATP2A2
ATXN1L
BBC3
BCAS2
BEGAIN
BFSP2
BICRAL
BLOC1S1
BORCS6
BRINP3
BSG
C1orf94
C20orf173
C3orf36
CASK
CBS
CCDC136
CCDC196
CCDC33
CCND3
CDR2
CDSN
CEACAM6
CEP55
CEP57L1
CEP63
CEP68
CFAP68
CIMIP2A
CLTC
COG8
CRMP1
CRX
CSNK2A1
CSTF2
CSTF2T
CTTNBP2NL
CYB5R2
DAAM2
DAZAP2
DCTN2
DECR1
DEUP1
DGCR6
DLG4
DNAAF19
DSN1
DTX2
DYDC1
EFHC2
EGFL7
EGFR
EHMT2
EIF3F
EPS15
ESRRG
EXOC3L1
EXOC5
EXOC7
EXOC8
EYA2
FAM168A
FAM185A
FANCG
FBN1
FCHSD2
FIGN
FLOT1
FLOT2
FNDC11
FOXD4L1
FOXI1
FSD2
FTCD
GATC
GFAP
GFI1B
GGA2
GKAP1
GOLGA2
GOLGA6L9
GOLGA7B
GUCA1C
HAP1
HAUS1
HNRNPDL
HNRNPM
HSF4
HSFY1
HSPA8
ICA1L
IFNA16
IFT74
IL2RB
IL4R
ILKAP
ING5
INTS4
IPO4
JAKMIP2
JMJD7
KIAA0753
KIAA0825
KLF4
KRT13
KRT14
KRT15
KRT16
KRT18
KRT19
KRT24
KRT25
KRT26
KRT27
KRT3
KRT31
KRT33B
KRT34
KRT35
KRT36
KRT37
KRT38
KRT39
KRT40
KRT6A
KRT75
KRT76
KRT82
KRT86
KRTAP19-5
KRTAP26-1
KRTAP7-1
LASP1
LDOC1
LINC00265
LITAF
LMO1
LMO4
LRRC61
LURAP1
LYST
MAGEB4
MAGED1
MAP3K1
MAP3K10
MAP3K7
MAPK1IP1L
MARK4
MAT2A
MED21
MED22
MED25
MED30
MED4
MED7
MEIS3
MEST
MET
METTL27
MIF4GD
MKNK1
MKRN3
MRFAP1L1
MTHFD1L
NADSYN1
NDC80
NDUFB10
NEDD4
NEDD8
NEFL
NF2
NFYC
NMI
NPAS2
NUP54
NUP62
NUTM2F
ODAM
OIP5
OSBPL5
P4HA3
PAK1
PAX5
PAX6
PEF1
PELP1
PFKM
PIK3R1
PITX1
PKNOX2
PLA2G10
PLAAT1
PLCD1
PLD3
PLEKHB2
PMEPA1
PNMA1
POGZ
POU2AF1
POU6F2
PPP1R16A
PPP1R7
PPP2R3B
PRR22
PRR5
PSMB11
PSMB4
PTCD3
RASSF4
RBCK1
RFC2
RFX6
RHOBTB3
RINT1
RNF4
RPRD1A
RPS3A
RSPO4
RSU1
RUNX1
SAPCD1
SAXO4
SCAMP3
SCRN1
SCT
SDS
SERGEF
SERTAD3
SF3B3
SHANK3
SMAD2
SMAD3
SMAD5
SMARCB1
SNAP25
SNX1
SNX5
SNX7
SORBS3
SPATA12
SPC25
SPIRE2
SPMIP6
SS18L1
STAM
STAM2
STK32C
STMN3
STX11
STXBP1
SUMO1
SUN2
SYK
TADA2A
TASOR2
TBX19
TCP11L2
TEKT1
TEKT5
TFG
TIMM10B
TIMMDC1
TJP2
TLE5
TMCC2
TOM1L1
TP53BP1
TRAF1
TRAF4
TRAK1
TRAP1
TRIM10
TRIM17
TRIM23
TRIM27
TRIM54
TRIM69
TRIM73
TRIML2
TSC1
TSG101
TUBB
TUBB2A
UBA1
UBA52
UBAP2
UBB
UBC
UBE2I
UBE4B
UBQLN1
UBQLN4
UBQLNL
UBXN11
USHBP1
USP54
VGLL3
VMP1
VPS37A
VPS37B
VPS37C
VPS37D
VPS52
WASHC1
WWP2
YPEL3
ZNF302
ZNF34
ZNF430
ZNF44
Entrez ID
3312
9146
HPRD ID
07205
05085
Ensembl ID
ENSG00000109971
ENSG00000185359
Uniprot IDs
P11142
Q53HF2
V9HW22
A0A0S2Z4R4
O14964
PDB IDs
3AGY
3AGZ
3ESK
3FZF
3FZH
3FZK
3FZL
3FZM
3LDQ
3M3Z
4H5N
4H5R
4H5T
4H5V
4H5W
4HWI
4KBQ
5AQF
5AQG
5AQH
5AQI
5AQJ
5AQK
5AQL
5AQM
5AQN
5AQO
5AQP
5AQQ
5AQR
5AQS
5AQT
5AQU
5AQV
6B1I
6B1M
6B1N
6ZYJ
2D3G
3F1I
3OBQ
3ZYQ
4AVX
Enriched GO Terms of Interacting Partners
?
Ubiquitin Protein Ligase Binding
Regulation Of Protein Stability
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Protein Folding
Positive Regulation Of Metabolic Process
Regulation Of Metabolic Process
Protein Stabilization
Negative Regulation Of Apoptotic Process
Enzyme Binding
Response To Stress
Negative Regulation Of Programmed Cell Death
Cytosol
Apoptotic Process
Programmed Cell Death
Positive Regulation Of Macromolecule Metabolic Process
Cell Death
Positive Regulation Of Programmed Cell Death
Adenyl-nucleotide Exchange Factor Activity
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Intracellular Signal Transduction
Regulation Of Primary Metabolic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Metabolic Process
Regulation Of Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Protein Modification Process
Heat Shock Protein Binding
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Multicellular Organismal Process
Hsp70 Protein Binding
Cellular Response To Stress
Regulation Of Signaling
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cell Communication
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Protein Folding Chaperone Complex
Negative Regulation Of Intracellular Signal Transduction
Response To Heat
Cellular Response To Oxygen-containing Compound
Negative Regulation Of Biosynthetic Process
Regulation Of Gene Expression
Positive Regulation Of Catabolic Process
Nucleus
Response To Peptide
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Intermediate Filament Organization
Structural Constituent Of Skin Epidermis
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Keratin Filament
Intermediate Filament
Protein Binding
Structural Molecule Activity
Organelle Organization
Epithelial Cell Differentiation
Supramolecular Fiber Organization
Cytoskeleton Organization
Cytoskeleton
Morphogenesis Of An Epithelium
Tissue Morphogenesis
Anatomical Structure Morphogenesis
Cellular Localization
Cytosol
Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Membrane Fission
Ubiquitin Protein Ligase Binding
Intracellular Transport
Intracellular Protein Localization
Establishment Of Protein Localization
Axonemal A Tubule Inner Sheath
Microtubule-based Process
Protein Transport
Establishment Of Protein Localization To Vacuole
Structural Constituent Of Cytoskeleton
Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway
Ubiquitin Binding
Establishment Of Localization In Cell
Endosome Transport Via Multivesicular Body Sorting Pathway
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
ESCRT I Complex
Protein Localization To Vacuole
Multivesicular Body Assembly
Multivesicular Body Organization
Endosomal Transport
Endosome Membrane
Multivesicular Body Sorting Pathway
Identical Protein Binding
Epidermis Development
Modification-dependent Protein Catabolic Process
Late Endosome To Vacuole Transport
Viral Budding
Protein Tag Activity
Core Mediator Complex
Exocyst
Organelle Localization
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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