HSPA8 and GAK

Number of citations of the paper that reports this interaction (PubMedID 10625686)
0

Data Source:
HPRD (in vivo, in vitro)

		HSPA8	GAK
Description		heat shock protein family A (Hsp70) member 8	cyclin G associated kinase
Image
GO Annotations	Cellular Component	Prp19 Complex Extracellular Region Extracellular Space Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Lysosome Lysosomal Membrane Cytosol Plasma Membrane Focal Adhesion Membrane Secretory Granule Lumen Melanosome Lysosomal Lumen Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Extracellular Exosome Blood Microparticle Lumenal Side Of Lysosomal Membrane Protein Folding Chaperone Complex Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex	Cytoplasm Golgi Apparatus Cytosol Focal Adhesion Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Anchoring Junction Presynapse
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding RNA Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Enzyme Binding MHC Class II Protein Complex Binding Protein-macromolecule Adaptor Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Cadherin Binding Receptor Ligand Activity Unfolded Protein Binding Protein-folding Chaperone Binding C3HC4-type RING Finger Domain Binding ATP-dependent Protein Disaggregase Activity ATP-dependent Protein Folding Chaperone	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Clathrin Binding Cyclin Binding Protein Folding Chaperone Protein Serine Kinase Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing Protein Folding Autophagy Response To Unfolded Protein Signal Transduction RNA Splicing Cellular Response To Starvation Negative Regulation Of Signal Transduction Protein Catabolic Process Positive Regulation Of Cell Migration Regulation Of Protein Stability Cellular Response To Stress Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Refolding Regulation Of Protein-containing Complex Assembly Negative Regulation Of DNA-templated Transcription ATP Metabolic Process Negative Regulation Of Cellular Component Organization Membrane Organization Regulation Of Protein Complex Stability Chaperone-mediated Autophagy Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Cellular Response To Steroid Hormone Stimulus Clathrin Coat Disassembly Negative Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Supramolecular Fiber Organization Negative Regulation Of Supramolecular Fiber Organization Regulation Of Protein Import Chaperone-mediated Autophagy Translocation Complex Disassembly	Protein Folding Receptor-mediated Endocytosis Endoplasmic Reticulum Organization Golgi Organization Negative Regulation Of Neuron Projection Development Synaptic Vesicle Uncoating Protein Localization To Golgi Apparatus Intracellular Transport Clathrin Coat Assembly Clathrin Coat Disassembly Clathrin-dependent Endocytosis Protein Localization To Plasma Membrane Golgi To Lysosome Transport Regulation Of Clathrin Coat Assembly
Pathways		Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis CHL1 interactions AUF1 (hnRNP D0) binds and destabilizes mRNA Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation mRNA Splicing - Major Pathway Clathrin-mediated endocytosis Protein methylation GABA synthesis, release, reuptake and degradation Lipophagy Chaperone Mediated Autophagy Late endosomal microautophagy Respiratory syncytial virus genome transcription PKR-mediated signaling	Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis
Drugs		Dasatinib (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Copper Artenimol	Fostamatinib
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 29403010 32888494) Postoperative acute renal failure after cardiac surgery ( 30678657) Red cell distribution width ( 32888494) Serum metabolite levels ( 33031748)	A body shape index ( 34021172) HDL cholesterol ( 30275531) Mortality in sepsis ( 27639821) Parkinson's disease ( 20711177 32310270 27182965 25064009 22438815 21738487 21292315) Parkinson's disease (age of onset) ( 30957308) Parkinson's disease (familial) ( 18985386) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Primary biliary cholangitis ( 26394269) Triglycerides ( 30275531) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		92 interacting genes: ABI1 AIPL1 ALDOB APOB ATM BAG1 BAG2 BAG3 BAG4 BAG6 BRCA1 CCT3 CD40 CDKN2A CITED1 CLTA COL7A1 CXCR4 CYCS DNAJA1 DNAJA3 DPP3 DYNLL1 EGFR ERBB3 ERH ESR1 FANCC FBP1 FNDC3B FOXP1 GAK GCH1 GOT2 H3C1 HDAC10 HDAC3 HGS HLTF HSF1 HSP90AA1 HSPA1A HSPBP1 HSPH1 HTN3 HTT IL32 JAK2 JUN LALBA LINC01554 MAPK8 MAPT NEDD8 NMI NOA1 PHC1 PPID PTEN PTPRF RAF1 RB1 REL RGS2 RNF26 SAYSD1 SIRPA SNCA SP1 SRRT ST13 STAT1 STIP1 STMN1 STUB1 SUMO2 SUMO4 TADA3 TCERG1 TGM2 TM4SF1 TNFRSF1A TRIM38 TSSK6 TTC1 UBC UCHL1 USP40 VHL WEE2-AS1 YWHAG YWHAQ	14 interacting genes: AP1M1 AP1M2 AP2M1 APP AR AXIN1 CCNG1 CDK5 CLTC CREBBP HSPA8 LRRK1 MFHAS1 USO1
Entrez ID		3312	2580
HPRD ID		07205	03631
Ensembl ID		ENSG00000109971	ENSG00000178950
Uniprot IDs		P11142 Q53HF2 V9HW22	B4DS37 O14976
PDB IDs		3AGY 3AGZ 3ESK 3FZF 3FZH 3FZK 3FZL 3FZM 3LDQ 3M3Z 4H5N 4H5R 4H5T 4H5V 4H5W 4HWI 4KBQ 5AQF 5AQG 5AQH 5AQI 5AQJ 5AQK 5AQL 5AQM 5AQN 5AQO 5AQP 5AQQ 5AQR 5AQS 5AQT 5AQU 5AQV 6B1I 6B1M 6B1N 6ZYJ	4C57 4C58 4C59 4O38 4Y8D 5Y7Z 5Y80
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Regulation Of Protein Stability Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Protein Folding Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Protein Stabilization Negative Regulation Of Apoptotic Process Enzyme Binding Response To Stress Negative Regulation Of Programmed Cell Death Cytosol Apoptotic Process Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Cell Death Positive Regulation Of Programmed Cell Death Adenyl-nucleotide Exchange Factor Activity Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Primary Metabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Protein Modification Process Heat Shock Protein Binding Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Multicellular Organismal Process Hsp70 Protein Binding Cellular Response To Stress Regulation Of Signaling Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Communication Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Folding Chaperone Complex Negative Regulation Of Intracellular Signal Transduction Response To Heat Cellular Response To Oxygen-containing Compound Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Catabolic Process Nucleus Response To Peptide Positive Regulation Of Protein Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process	Intracellular Transport Intracellular Protein Transport Clathrin Adaptor Complex Regulation Of Protein Localization Clathrin Adaptor Activity Acetylcholine Receptor Activator Activity Negative Regulation Of Protein Localization Cellular Localization Establishment Of Localization In Cell Low-density Lipoprotein Particle Receptor Binding Regulation Of Protein Import Trans-Golgi Network Membrane Regulation Of Protein Localization To Plasma Membrane Cytoplasmic Vesicle Clathrin Coat Disassembly Regulation Of Protein Localization To Cell Periphery Vesicle Uncoating Regulation Of Protein Localization To Membrane Protein Transport Vesicle-mediated Transport Clathrin-coated Pit P53 Binding Clathrin-coated Vesicle Establishment Of Protein Localization AP-1 Adaptor Complex Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Negative Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Binding Endolysosome Membrane Transcytosis Cytosol Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Serine/threonine Kinase Binding Clathrin-coated Endocytic Vesicle Negative Regulation Of Macromolecule Biosynthetic Process Disordered Domain Specific Binding Regulation Of JNK Cascade Regulation Of Proteolysis Negative Regulation Of Biosynthetic Process Positive Regulation Of Receptor Internalization Lysosomal Membrane Regulation Of Synaptic Vesicle Recycling Negative Regulation Of Protein Localization To Plasma Membrane Enzyme Binding Regulation Of Protein Localization To Nucleus Clathrin-dependent Endocytosis Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Component Assembly
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