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HSPA8 and HSF1
Number of citations of the paper that reports this interaction (PubMedID
7639722
)
0
Data Source:
HPRD
(in vitro, in vivo)
HSPA8
HSF1
Description
heat shock protein family A (Hsp70) member 8
heat shock transcription factor 1
Image
GO Annotations
Cellular Component
Prp19 Complex
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Spliceosomal Complex
Nucleolus
Cytoplasm
Lysosome
Lysosomal Membrane
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Secretory Granule Lumen
Melanosome
Lysosomal Lumen
Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane
Extracellular Exosome
Blood Microparticle
Lumenal Side Of Lysosomal Membrane
Protein Folding Chaperone Complex
Ficolin-1-rich Granule Lumen
Ribonucleoprotein Complex
Chromosome, Centromeric Region
Kinetochore
Chromatin
Euchromatin
Heterochromatin
Spindle Pole
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
PML Body
Protein-containing Complex
Pronucleus
Perinuclear Region Of Cytoplasm
Nuclear Stress Granule
Mitotic Spindle Pole
Protein Folding Chaperone Complex
Ribonucleoprotein Complex
Molecular Function
Nucleotide Binding
G Protein-coupled Receptor Binding
RNA Binding
Protein Binding
ATP Binding
Hydrolase Activity
ATP Hydrolysis Activity
Enzyme Binding
MHC Class II Protein Complex Binding
Protein-macromolecule Adaptor Activity
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Protein Folding Chaperone
Cadherin Binding
Receptor Ligand Activity
Unfolded Protein Binding
Protein-folding Chaperone Binding
C3HC4-type RING Finger Domain Binding
ATP-dependent Protein Disaggregase Activity
ATP-dependent Protein Folding Chaperone
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Kinase Binding
Heat Shock Protein Binding
Chromatin DNA Binding
Identical Protein Binding
Sequence-specific DNA Binding
Protein Heterodimerization Activity
Hsp90 Protein Binding
Translation Elongation Factor Binding
STAT Family Protein Binding
Sequence-specific Single Stranded DNA Binding
General Transcription Initiation Factor Binding
Sequence-specific Double-stranded DNA Binding
Promoter-specific Chromatin Binding
Biological Process
MRNA Splicing, Via Spliceosome
MRNA Processing
Protein Folding
Autophagy
Response To Unfolded Protein
Signal Transduction
RNA Splicing
Cellular Response To Starvation
Negative Regulation Of Signal Transduction
Protein Catabolic Process
Positive Regulation Of Cell Migration
Regulation Of Protein Stability
Cellular Response To Stress
Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Protein Refolding
Regulation Of Protein-containing Complex Assembly
Negative Regulation Of DNA-templated Transcription
ATP Metabolic Process
Negative Regulation Of Cellular Component Organization
Membrane Organization
Regulation Of Protein Complex Stability
Chaperone-mediated Autophagy
Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy
Cellular Response To Steroid Hormone Stimulus
Clathrin Coat Disassembly
Negative Regulation Of NLRP3 Inflammasome Complex Assembly
Regulation Of Supramolecular Fiber Organization
Negative Regulation Of Supramolecular Fiber Organization
Regulation Of Protein Import
Chaperone-mediated Autophagy Translocation Complex Disassembly
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
In Utero Embryonic Development
Embryonic Placenta Development
DNA Repair
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
MRNA Processing
Defense Response
DNA Damage Response
Female Meiotic Nuclear Division
Spermatogenesis
Response To Nutrient
Cell Population Proliferation
Response To Heat
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Response To Activity
Negative Regulation Of Protein-containing Complex Assembly
Response To Estradiol
Response To Lipopolysaccharide
Negative Regulation Of Tumor Necrosis Factor Production
Response To Testosterone
Cellular Response To Heat
Cellular Response To Unfolded Protein
Cellular Response To Potassium Ion
Positive Regulation Of Multicellular Organism Growth
Response To Amino Acid
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Epithelial Cell Proliferation
Negative Regulation Of Epithelial Cell Proliferation
MRNA Transport
Embryonic Process Involved In Female Pregnancy
Positive Regulation Of Stress Granule Assembly
Protein-containing Complex Assembly
Cellular Response To Hydrogen Peroxide
Cellular Response To Lipopolysaccharide
Cellular Response To Amino Acid Stimulus
Cellular Response To Cadmium Ion
Cellular Response To Copper Ion
Cellular Response To Estradiol Stimulus
Cellular Response To Xenobiotic Stimulus
Cellular Response To Radiation
Cellular Response To Gamma Radiation
Cellular Response To Diamide
Negative Regulation Of Inclusion Body Assembly
Positive Regulation Of Inclusion Body Assembly
Positive Regulation Of Cold-induced Thermogenesis
Regulation Of Cellular Response To Heat
Response To Peptide
Positive Regulation Of Apoptotic DNA Fragmentation
Cellular Response To Sodium Arsenite
Cellular Response To Angiotensin
Cellular Response To Nitroglycerin
Cellular Response To L-glutamine
Response To Hypobaric Hypoxia
Response To Psychosocial Stress
Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Positive Regulation Of Apoptotic Signaling Pathway
Pathways
Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Attenuation phase
HSF1-dependent transactivation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
CHL1 interactions
AUF1 (hnRNP D0) binds and destabilizes mRNA
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
mRNA Splicing - Major Pathway
Clathrin-mediated endocytosis
Protein methylation
GABA synthesis, release, reuptake and degradation
Lipophagy
Chaperone Mediated Autophagy
Late endosomal microautophagy
Respiratory syncytial virus genome transcription
PKR-mediated signaling
Regulation of HSF1-mediated heat shock response
HSF1 activation
Attenuation phase
HSF1-dependent transactivation
Aggrephagy
Mitochondrial unfolded protein response (UPRmt)
Drugs
Dasatinib
(2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Copper
Artenimol
Bimoclomol
Diseases
GWAS
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular hemoglobin concentration (
29403010
32888494
)
Postoperative acute renal failure after cardiac surgery (
30678657
)
Red cell distribution width (
32888494
)
Serum metabolite levels (
33031748
)
Dupuytren's disease (
28886342
)
Interacting Genes
92 interacting genes:
ABI1
AIPL1
ALDOB
APOB
ATM
BAG1
BAG2
BAG3
BAG4
BAG6
BRCA1
CCT3
CD40
CDKN2A
CITED1
CLTA
COL7A1
CXCR4
CYCS
DNAJA1
DNAJA3
DPP3
DYNLL1
EGFR
ERBB3
ERH
ESR1
FANCC
FBP1
FNDC3B
FOXP1
GAK
GCH1
GOT2
H3C1
HDAC10
HDAC3
HGS
HLTF
HSF1
HSP90AA1
HSPA1A
HSPBP1
HSPH1
HTN3
HTT
IL32
JAK2
JUN
LALBA
LINC01554
MAPK8
MAPT
NEDD8
NMI
NOA1
PHC1
PPID
PTEN
PTPRF
RAF1
RB1
REL
RGS2
RNF26
SAYSD1
SIRPA
SNCA
SP1
SRRT
ST13
STAT1
STIP1
STMN1
STUB1
SUMO2
SUMO4
TADA3
TCERG1
TGM2
TM4SF1
TNFRSF1A
TRIM38
TSSK6
TTC1
UBC
UCHL1
USP40
VHL
WEE2-AS1
YWHAG
YWHAQ
52 interacting genes:
CAMK2A
CDC20
CDK6
CEBPB
CHST10
CREBBP
CSNK2A1
DAXX
DNAJB1
ENO2
FILIP1
FKBP4
FKBP5
GSK3A
GTF2A2
GTF2B
HSBP1
HSF2
HSP90AA1
HSPA1A
HSPA8
MAPK1
MAPK3
MAPK8
MAPK9
MAPKAPK2
NCOA6
OTUB1
PIM2
PPID
PRKDC
PTGES3
RALBP1
REPS1
RNF20
SMARCA4
STAT1
STUB1
SUB1
SUMO1
SUMO3
SYMPK
TAF1
TAF7
TAF9
TBP
TRRAP
UBC
UBE2I
XRCC5
XRCC6
YWHAE
Entrez ID
3312
3297
HPRD ID
07205
00778
Ensembl ID
ENSG00000109971
ENSG00000185122
Uniprot IDs
P11142
Q53HF2
V9HW22
Q00613
PDB IDs
3AGY
3AGZ
3ESK
3FZF
3FZH
3FZK
3FZL
3FZM
3LDQ
3M3Z
4H5N
4H5R
4H5T
4H5V
4H5W
4HWI
4KBQ
5AQF
5AQG
5AQH
5AQI
5AQJ
5AQK
5AQL
5AQM
5AQN
5AQO
5AQP
5AQQ
5AQR
5AQS
5AQT
5AQU
5AQV
6B1I
6B1M
6B1N
6ZYJ
2LDU
5D5U
5D5V
5HDG
5HDN
7DCJ
7DCS
7DCT
Enriched GO Terms of Interacting Partners
?
Ubiquitin Protein Ligase Binding
Regulation Of Protein Stability
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Protein Folding
Positive Regulation Of Metabolic Process
Regulation Of Metabolic Process
Protein Stabilization
Negative Regulation Of Apoptotic Process
Enzyme Binding
Response To Stress
Negative Regulation Of Programmed Cell Death
Cytosol
Apoptotic Process
Programmed Cell Death
Positive Regulation Of Macromolecule Metabolic Process
Cell Death
Positive Regulation Of Programmed Cell Death
Adenyl-nucleotide Exchange Factor Activity
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Intracellular Signal Transduction
Regulation Of Primary Metabolic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Metabolic Process
Regulation Of Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Protein Modification Process
Heat Shock Protein Binding
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Multicellular Organismal Process
Hsp70 Protein Binding
Cellular Response To Stress
Regulation Of Signaling
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cell Communication
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Protein Folding Chaperone Complex
Negative Regulation Of Intracellular Signal Transduction
Response To Heat
Cellular Response To Oxygen-containing Compound
Negative Regulation Of Biosynthetic Process
Regulation Of Gene Expression
Positive Regulation Of Catabolic Process
Nucleus
Response To Peptide
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Nucleoplasm
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Metabolic Process
Cellular Response To Stress
Nucleus
Cellular Response To Heat
Positive Regulation Of Metabolic Process
Regulation Of Protein Stability
Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Stabilization
Enzyme Binding
Regulation Of DNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Response To Heat
ATP Binding
Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Cytosol
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Biosynthetic Process
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Cellular Response To Stress
Transcription Factor TFIID Complex
Protein Serine Kinase Activity
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Transcription Preinitiation Complex Assembly
Regulation Of Gene Expression
DNA Damage Response
Heat Shock Protein Binding
Nucleic Acid Metabolic Process
Ubiquitin Protein Ligase Binding
Macromolecule Metabolic Process
RNA Polymerase II General Transcription Initiation Factor Activity
Protein Serine/threonine Kinase Activity
DNA-templated Transcription Initiation
Nucleobase-containing Compound Metabolic Process
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Negative Regulation Of Metabolic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Protein Modification Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
RNA Polymerase II Preinitiation Complex Assembly
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