HSPA8 and LALBA

Number of citations: 0 (PubMedID 20618441)
Data Source: BioGRID (pull down)

		HSPA8	LALBA
Name		heat shock protein family A (Hsp70) member 8	lactalbumin alpha
Structure
GO Annotations	Cellular Component	Prp19 Complex Extracellular Region Extracellular Space Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Lysosome Lysosomal Membrane Cytosol Plasma Membrane Focal Adhesion Membrane Secretory Granule Lumen Melanosome Lysosomal Lumen Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Extracellular Exosome Blood Microparticle Lumenal Side Of Lysosomal Membrane Protein Folding Chaperone Complex Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex	Golgi Membrane Extracellular Region Extracellular Space Golgi Lumen Protein-containing Complex
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding RNA Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Enzyme Binding MHC Class II Protein Complex Binding Protein-macromolecule Adaptor Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Cadherin Binding Receptor Ligand Activity Unfolded Protein Binding Protein-folding Chaperone Binding C3HC4-type RING Finger Domain Binding ATP-dependent Protein Disaggregase Activity ATP-dependent Protein Folding Chaperone	Lysozyme Activity Lactose Synthase Activity Calcium Ion Binding Metal Ion Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing Protein Folding Autophagy Response To Unfolded Protein Signal Transduction RNA Splicing Cellular Response To Starvation Negative Regulation Of Signal Transduction Protein Catabolic Process Positive Regulation Of Cell Migration Regulation Of Protein Stability Cellular Response To Stress Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Refolding Regulation Of Protein-containing Complex Assembly Negative Regulation Of DNA-templated Transcription ATP Metabolic Process Negative Regulation Of Cellular Component Organization Membrane Organization Regulation Of Protein Complex Stability Chaperone-mediated Autophagy Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Cellular Response To Steroid Hormone Stimulus Clathrin Coat Disassembly Negative Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Supramolecular Fiber Organization Negative Regulation Of Supramolecular Fiber Organization Regulation Of Protein Import Chaperone-mediated Autophagy Translocation Complex Disassembly	Lactose Biosynthetic Process Apoptotic Process Signal Transduction Cell-cell Signaling Defense Response To Bacterium Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium
Pathways		Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis CHL1 interactions AUF1 (hnRNP D0) binds and destabilizes mRNA Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation mRNA Splicing - Major Pathway Clathrin-mediated endocytosis Protein methylation GABA synthesis, release, reuptake and degradation Lipophagy Chaperone Mediated Autophagy Late endosomal microautophagy Respiratory syncytial virus genome transcription PKR-mediated signaling	Lactose synthesis Developmental Lineage of Mammary Gland Alveolar Cells
Drugs		Dasatinib (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Copper Artenimol	Palmitic Acid
GWAS		Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular hemoglobin concentration ( 29403010 32888494 ) Postoperative acute renal failure after cardiac surgery ( 30678657 ) Red cell distribution width ( 32888494 ) Serum metabolite levels ( 33031748 )	Adiponectin levels ( 24105470 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 )
Interacting Genes		92 interacting genes: ABI1 AIPL1 ALDOB APOB ATM BAG1 BAG2 BAG3 BAG4 BAG6 BRCA1 CCT3 CD40 CDKN2A CITED1 CLTA COL7A1 CXCR4 CYCS DNAJA1 DNAJA3 DPP3 DYNLL1 EGFR ERBB3 ERH ESR1 FANCC FBP1 FNDC3B FOXP1 GAK GCH1 GOT2 H3C1 HDAC10 HDAC3 HGS HLTF HSF1 HSP90AA1 HSPA1A HSPBP1 HSPH1 HTN3 HTT IL32 JAK2 JUN LALBA LINC01554 MAPK8 MAPT NEDD8 NMI NOA1 PHC1 PPID PTEN PTPRF RAF1 RB1 REL RGS2 RNF26 SAYSD1 SIRPA SNCA SP1 SRRT ST13 STAT1 STIP1 STMN1 STUB1 SUMO2 SUMO4 TADA3 TCERG1 TGM2 TM4SF1 TNFRSF1A TRIM38 TSSK6 TTC1 UBC UCHL1 USP40 VHL WEE2-AS1 YWHAG YWHAQ	6 interacting genes: B4GALT1 CRYAA CRYAB H2BC21 H3C15 HSPA8
Entrez ID		3312	3906
HPRD ID		07205	01024
Ensembl ID		ENSG00000109971	ENSG00000167531
Uniprot IDs		P11142 Q53HF2 V9HW22	A0A080YV01 P00709
PDB IDs		3AGY 3AGZ 3ESK 3FZF 3FZH 3FZK 3FZL 3FZM 3LDQ 3M3Z 4H5N 4H5R 4H5T 4H5V 4H5W 4HWI 4KBQ 5AQF 5AQG 5AQH 5AQI 5AQJ 5AQK 5AQL 5AQM 5AQN 5AQO 5AQP 5AQQ 5AQR 5AQS 5AQT 5AQU 5AQV 6B1I 6B1M 6B1N 6ZYJ	1A4V 1B9O 1CB3 1HML 3B0I 3B0O 4L41
GO Terms Enriched among Interactors		Ubiquitin Protein Ligase Binding Regulation Of Protein Stability Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Protein Folding Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Protein Stabilization Negative Regulation Of Apoptotic Process Enzyme Binding Response To Stress Negative Regulation Of Programmed Cell Death Cytosol Apoptotic Process Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Cell Death Positive Regulation Of Programmed Cell Death Adenyl-nucleotide Exchange Factor Activity Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Primary Metabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Protein Modification Process Heat Shock Protein Binding Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Multicellular Organismal Process Hsp70 Protein Binding Cellular Response To Stress Regulation Of Signaling Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Communication Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Folding Chaperone Complex Negative Regulation Of Intracellular Signal Transduction Response To Heat Cellular Response To Oxygen-containing Compound Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Catabolic Process Nucleus Response To Peptide Positive Regulation Of Protein Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process	Protein Refolding Tubulin Complex Assembly Unfolded Protein Binding Protein-containing Complex Organization Structural Constituent Of Eye Lens Apoptotic Process Involved In Morphogenesis Protein Folding Apoptotic Process Involved In Development Lens Development In Camera-type Eye Extracellular Exosome Negative Regulation Of Intracellular Transport Regulation Of Protein Stability Response To Heat Camera-type Eye Development Protein-containing Complex Assembly Positive Regulation Of Circulating Fibrinogen Levels Chaperone-mediated Autophagy Translocation Complex Disassembly Structural Constituent Of Chromatin Response To Hydrogen Peroxide Lactose Biosynthetic Process Lumenal Side Of Lysosomal Membrane Nucleosome Nucleosome Assembly Eye Development Response To Stress Negative Regulation Of Protein-containing Complex Assembly UDP-galactosyltransferase Activity Lactose Synthase Activity Regulation Of Protein Import Nucleosome Organization Response To Temperature Stimulus Response To Reactive Oxygen Species Negative Regulation Of Supramolecular Fiber Organization N-acetyllactosamine Synthase Activity Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Sensory Organ Development Structural Molecule Activity Protein-containing Complex C3HC4-type RING Finger Domain Binding Clathrin Coat Disassembly Protein-DNA Complex Assembly Development Of Secondary Sexual Characteristics ATP-dependent Protein Disaggregase Activity Vesicle Uncoating Lens Fiber Cell Morphogenesis Cardiac Myofibril Galactosyltransferase Activity Chaperone-mediated Autophagy Protein Stabilization