HSPA8 and CITED1

Number of citations of the paper that reports this interaction (PMID 10722728)
19

Data Source:
BioGRID (genetic interference)
HPRD (in vivo, in vitro)

		HSPA8	CITED1
Gene Name		heat shock 70kDa protein 8	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Prp19 Complex Extracellular Space Intracellular Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytosol Plasma Membrane Focal Adhesion Membrane Ribonucleoprotein Complex Melanosome Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Extracellular Vesicular Exosome Blood Microparticle	Nucleus Cytoplasm Cytosol
	Molecular Function	G-protein Coupled Receptor Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding MHC Class II Protein Complex Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding ATPase Activity, Coupled Poly(A) RNA Binding Unfolded Protein Binding	Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Protein C-terminus Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding LBD Domain Binding Co-SMAD Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription, DNA-templated Protein Folding Post-Golgi Vesicle-mediated Transport Response To Unfolded Protein Synaptic Transmission Neurotransmitter Secretion Axon Guidance RNA Splicing Gene Expression Viral Process Cellular Response To Heat Protein Refolding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of MRNA Splicing, Via Spliceosome Chaperone Mediated Protein Folding Requiring Cofactor Regulation Of Cell Cycle Membrane Organization Clathrin Coat Disassembly Regulation Of Cellular Response To Heat Negative Regulation Of Fibril Organization	Embryonic Axis Specification Vasculogenesis Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Placenta Development Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Nucleocytoplasmic Transport Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Brain Development Cell Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Wnt Signaling Pathway Melanocyte Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Lipopolysaccharide Response To Insulin Response To Cytokine Response To Interferon-gamma Melanin Biosynthetic Process Pigmentation Negative Regulation Of Neuron Apoptotic Process Response To Estrogen Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Response To CAMP Mesenchymal To Epithelial Transition SMAD Protein Signal Transduction Labyrinthine Layer Development Spongiotrophoblast Layer Development Response To Interleukin-1 Response To Interleukin-2 Response To Interleukin-4 Response To Interleukin-6 Response To Interleukin-9 Response To Interleukin-11 Response To Parathyroid Hormone Response To Transforming Growth Factor Beta
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing Regulation of mRNA stability by proteins that bind AU-rich elements Axon guidance Golgi Associated Vesicle Biogenesis Attenuation phase mRNA Splicing - Major Pathway L1CAM interactions Regulation of HSF1-mediated heat shock response Cellular response to heat stress AUF1 (hnRNP D0) destabilizes mRNA GABA synthesis, release, reuptake and degradation Clathrin derived vesicle budding Lysosome Vesicle Biogenesis HSF1-dependent transactivation Neurotransmitter Release Cycle CHL1 interactions trans-Golgi Network Vesicle Budding Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		83 interactors: ABI1 AIPL1 ALDOB APOB BAG1 BAG2 BAG3 BAG4 BAG6 BRCA1 CAPZA1 CAPZB CCAR2 CCT3 CD40 CDKN2A CITED1 CLTA COL7A1 CXCR4 CYCS DNAJA1 DNAJA3 DNAJB1 DNAJC7 DPP3 DYNLL1 EGFR ERH ESR1 FANCC FBP1 GAK GCH1 GOT2 HDAC10 HDAC3 HGS HLTF HSF1 HSP90AA1 HSPA1A HSPBP1 HSPH1 HTT IL32 JAK2 JUN LALBA MAPK8 MAPT METTL21A NMI NOA1 PHC1 PPID RAF1 RB1 REL RGS2 SGTA SNCA SP1 SRRT ST13 STIP1 STMN1 STUB1 SUMO4 TADA3 TCERG1 TCP1 TGM2 TM4SF1 TNFRSF1A TRIM38 TSSK6 TTC1 UBC UCHL1 VHL YWHAG YWHAQ	8 interactors: CREBBP EP300 ESR1 HSPA8 LNX1 SMAD4 TFAP2B TFAP2C
Entrez ID		3312	4435
HPRD ID		07205	02146
Ensembl ID		ENSG00000109971	ENSG00000125931
Uniprot IDs		P11142 Q53HF2	Q99966
PDB IDs		3AGY 3AGZ 3ESK 3FZF 3FZH 3FZK 3FZL 3FZM 3LDQ 3M3Z 4HWI
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Death Protein Folding Regulation Of Apoptotic Process Apoptotic Process Programmed Cell Death Cell Death Death Protein Refolding Response To Stress Regulation Of Signal Transduction Response To Stimulus Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Response To Organic Substance Cellular Response To Stimulus Regulation Of Signaling Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Response To Abiotic Stimulus Protein Metabolic Process Regulation Of Protein Stability Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Protein Metabolic Process Apoptotic Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Negative Regulation Of Signaling Defense Response Chaperone Cofactor-dependent Protein Refolding Regulation Of Intracellular Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Positive Regulation Of Signal Transduction Cell Communication Cellular Response To Organic Substance Protein Complex Assembly Negative Regulation Of Phosphorylation Positive Regulation Of Cellular Metabolic Process	Negative Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Cellular Response To Heat Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Negative Regulation Of Biosynthetic Process Anatomical Structure Morphogenesis Cellular Response To Heat Tube Development Germ-line Stem Cell Maintenance Branch Elongation Involved In Mammary Gland Duct Branching Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Sebaceous Gland Development Regulation Of Transcription From RNA Polymerase II Promoter Response To Heat N-terminal Protein Amino Acid Acetylation RNA Metabolic Process Organ Morphogenesis Positive Regulation Of Metabolic Process Epithelium Development Gene Expression Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Stem Cell Maintenance Macromolecule Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Mammary Gland Epithelial Cell Proliferation Branch Elongation Of An Epithelium Response To Temperature Stimulus Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Branching Morphogenesis Of An Epithelial Tube Tissue Morphogenesis N-terminal Protein Amino Acid Modification Regulation Of Transcription, DNA-templated Skin Development DNA-templated Transcription, Initiation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Morphogenesis Of A Branching Epithelium
Tagcloud ?		alteration cadherin cd133 cognate ectopically electrophoresis filament glioblastoma glioblastomas gliomas hairpin hsc71 interfere invasion modulating nanog nestin oct overexpress progenitor restored shrna sphere stemness suppresses transfected transfection tumorigenic vi	calm3 cblb ccna2 ccnd3 cdk6 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Difference) ?		alteration cadherin cd133 cognate ectopically electrophoresis filament glioblastoma glioblastomas gliomas hairpin hsc71 interfere invasion modulating nanog nestin oct overexpress progenitor restored shrna sphere stemness suppresses transfected transfection tumorigenic vi	calm3 cblb ccna2 ccnd3 cdk6 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Intersection) ?