HSPA8 and BAG2

Number of citations of the paper that reports this interaction (PMID 9873016)
84

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo, two hybrid)

		HSPA8	BAG2
Gene Name		heat shock 70kDa protein 8	BCL2-associated athanogene 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Prp19 Complex Extracellular Space Intracellular Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytosol Plasma Membrane Focal Adhesion Membrane Ribonucleoprotein Complex Melanosome Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	G-protein Coupled Receptor Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding MHC Class II Protein Complex Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding ATPase Activity, Coupled Poly(A) RNA Binding Unfolded Protein Binding	Protein Binding Identical Protein Binding Chaperone Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription, DNA-templated Protein Folding Post-Golgi Vesicle-mediated Transport Response To Unfolded Protein Synaptic Transmission Neurotransmitter Secretion Axon Guidance RNA Splicing Gene Expression Viral Process Cellular Response To Heat Protein Refolding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of MRNA Splicing, Via Spliceosome Chaperone Mediated Protein Folding Requiring Cofactor Regulation Of Cell Cycle Membrane Organization Clathrin Coat Disassembly Regulation Of Cellular Response To Heat Negative Regulation Of Fibril Organization	Protein Folding Protein Metabolic Process
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing Regulation of mRNA stability by proteins that bind AU-rich elements Axon guidance Golgi Associated Vesicle Biogenesis Attenuation phase mRNA Splicing - Major Pathway L1CAM interactions Regulation of HSF1-mediated heat shock response Cellular response to heat stress AUF1 (hnRNP D0) destabilizes mRNA GABA synthesis, release, reuptake and degradation Clathrin derived vesicle budding Lysosome Vesicle Biogenesis HSF1-dependent transactivation Neurotransmitter Release Cycle CHL1 interactions trans-Golgi Network Vesicle Budding Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		83 interactors: ABI1 AIPL1 ALDOB APOB BAG1 BAG2 BAG3 BAG4 BAG6 BRCA1 CAPZA1 CAPZB CCAR2 CCT3 CD40 CDKN2A CITED1 CLTA COL7A1 CXCR4 CYCS DNAJA1 DNAJA3 DNAJB1 DNAJC7 DPP3 DYNLL1 EGFR ERH ESR1 FANCC FBP1 GAK GCH1 GOT2 HDAC10 HDAC3 HGS HLTF HSF1 HSP90AA1 HSPA1A HSPBP1 HSPH1 HTT IL32 JAK2 JUN LALBA MAPK8 MAPT METTL21A NMI NOA1 PHC1 PPID RAF1 RB1 REL RGS2 SGTA SNCA SP1 SRRT ST13 STIP1 STMN1 STUB1 SUMO4 TADA3 TCERG1 TCP1 TGM2 TM4SF1 TNFRSF1A TRIM38 TSSK6 TTC1 UBC UCHL1 VHL YWHAG YWHAQ	12 interactors: CCAR2 DNAJC6 HSPA1A HSPA4 HSPA8 MAPKAPK2 NOTCH3 PINK1 PPIH SLU7 WDR77 WDR83
Entrez ID		3312	9532
HPRD ID		07205	04859
Ensembl ID		ENSG00000109971
Uniprot IDs		P11142 Q53HF2	B4DXE2 O95816
PDB IDs		3AGY 3AGZ 3ESK 3FZF 3FZH 3FZK 3FZL 3FZM 3LDQ 3M3Z 4HWI
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Death Protein Folding Regulation Of Apoptotic Process Apoptotic Process Programmed Cell Death Cell Death Death Protein Refolding Response To Stress Regulation Of Signal Transduction Response To Stimulus Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Response To Organic Substance Cellular Response To Stimulus Regulation Of Signaling Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Response To Abiotic Stimulus Protein Metabolic Process Regulation Of Protein Stability Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Protein Metabolic Process Apoptotic Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Negative Regulation Of Signaling Defense Response Chaperone Cofactor-dependent Protein Refolding Regulation Of Intracellular Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Positive Regulation Of Signal Transduction Cell Communication Cellular Response To Organic Substance Protein Complex Assembly Negative Regulation Of Phosphorylation Positive Regulation Of Cellular Metabolic Process	Cellular Response To Heat Regulation Of Cellular Response To Heat Response To Heat MRNA Metabolic Process RNA Splicing Response To Temperature Stimulus MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing Clathrin Coat Disassembly Gene Expression Response To Abiotic Stimulus RNA Metabolic Process Response To Unfolded Protein Regulation Of Protein Stability Cellular Response To Stress Protein Refolding Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Apoptotic Signaling Pathway Protein Folding Nucleobase-containing Compound Metabolic Process Response To Stress Positive Regulation Of DNA Damage Checkpoint Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Fibril Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Post-Golgi Vesicle-mediated Transport Mitochondrion Organization Protein Stabilization Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cellular Response To Hypoxia Cellular Heat Acclimation Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Fibril Organization Nitrogen Compound Metabolic Process Peptidyl-serine Phosphorylation Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Protein Import Into Mitochondrial Outer Membrane Positive Regulation Of Cellular Respiration Cellular Protein Metabolic Process Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Death MRNA 3'-splice Site Recognition Regulation Of Cellular Response To Hypoxia
Tagcloud ?		alteration cadherin cd133 cognate ectopically electrophoresis filament glioblastoma glioblastomas gliomas hairpin hsc71 interfere invasion modulating nanog nestin oct overexpress progenitor restored shrna sphere stemness suppresses transfected transfection tumorigenic vi	abolished ameliorates athanogene balance collapse cytochrome dimer disassociation dj elucidated homodimer link modulating monomer monomerization mpp neurodegeneration neuroprotective overexpressed overexpressing parkinson partners pd phenylpyridinium prevents property pulldown strengthening
Tagcloud (Difference) ?		alteration cadherin cd133 cognate ectopically electrophoresis filament glioblastoma glioblastomas gliomas hairpin hsc71 interfere invasion nanog nestin oct overexpress progenitor restored shrna sphere stemness suppresses transfected transfection tumorigenic vi	abolished ameliorates athanogene balance collapse cytochrome dimer disassociation dj elucidated homodimer link monomer monomerization mpp neurodegeneration neuroprotective overexpressed overexpressing parkinson partners pd phenylpyridinium prevents property pulldown strengthening
Tagcloud (Intersection) ?		modulating