RAB5A and CHM

Number of citations of the paper that reports this interaction (PMID 8294464)
30

Data Source:
BioGRID (pull down)

		RAB5A	CHM
Gene Name		RAB5A, member RAS oncogene family	choroideremia (Rab escort protein 1)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Synaptic Vesicle Endosome Membrane Actin Cytoskeleton Endocytic Vesicle Axon Dendrite Somatodendritic Compartment Melanosome Zymogen Granule Membrane Neuronal Cell Body Terminal Bouton Protein Complex Axon Terminus Membrane Raft Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Vesicular Exosome Cytoplasmic Side Of Early Endosome Membrane	Cytosol Rab-protein Geranylgeranyltransferase Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding GDP-dissociation Inhibitor Binding	Rab Geranylgeranyltransferase Activity GTPase Activator Activity Rab GTPase Binding
	Biological Process	Intracellular Protein Transport Endocytosis Blood Coagulation Positive Regulation Of Smooth Muscle Cell Migration Regulation Of Endocytosis Rab Protein Signal Transduction Synaptic Vesicle Recycling Early Endosome To Late Endosome Transport Positive Regulation Of Exocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Endosome Size Regulation Of Filopodium Assembly Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Synaptic Vesicle Exocytosis	Blood Vessel Development Protein Targeting To Membrane Visual Perception Protein Geranylgeranylation Positive Regulation Of GTPase Activity Response To Stimulus
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS
Protein-Protein Interactions		41 interactors: AGTR1 ALS2CL ANKFY1 AP1G1 AP1G2 APPL1 APPL2 CHM CHML EEA1 GDI2 GGA1 GGA2 GGA3 GRIK4 ITSN1 NME2 OCRL RAB37 RAB7A RABAC1 RABEP1 RABEP2 RABGGTB RASA1 RBSN RIN1 RIN2 RIN3 RIT2 RUFY1 SDCBP SGSM3 STX4 SUN2 TBC1D15 TBC1D17 TBC1D3C TBC1D3F TSC2 USP6NL	13 interactors: RAB14 RAB18 RAB1A RAB1B RAB32 RAB3A RAB3B RAB3D RAB4A RAB5A RAB5B RAB6A RAB7A
Entrez ID		5868	1121
HPRD ID		01542	02312
Ensembl ID		ENSG00000144566	ENSG00000188419
Uniprot IDs		B4DJA5 P20339	P24386
PDB IDs		1N6H 1N6I 1N6K 1N6L 1N6N 1N6O 1N6P 1N6R 1R2Q 1TU3 1TU4 3MJH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Positive Regulation Of Hydrolase Activity Vesicle-mediated Transport Positive Regulation Of Catalytic Activity Positive Regulation Of Ras GTPase Activity Regulation Of Ras GTPase Activity Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Regulation Of Catalytic Activity Regulation Of Ras Protein Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Small GTPase Mediated Signal Transduction Protein Transport Protein Localization Establishment Of Protein Localization Establishment Of Localization In Cell Intracellular Transport Transport Cellular Localization Endocytosis Intracellular Protein Transport Regulation Of Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Endosomal Transport Regulation Of Signaling Regulation Of Signal Transduction Membrane Organization Cellular Protein Localization Protein Geranylgeranylation Regulation Of Vesicle-mediated Transport Regulation Of Metabolic Process Vesicle Fusion Membrane Fusion Positive Regulation Of Exocytosis Protein Prenylation Regulation Of Exocytosis Organelle Fusion Golgi To Lysosome Transport Vesicle Organization Intracellular Signal Transduction Ras Protein Signal Transduction Lysosomal Transport Golgi To Vacuole Transport Plasma Membrane To Endosome Transport Cytoplasmic Transport Signaling Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion	Rab Protein Signal Transduction Ras Protein Signal Transduction Small GTPase Mediated Signal Transduction Intracellular Protein Transport Cellular Protein Localization Protein Transport Establishment Of Protein Localization Intracellular Transport Intracellular Signal Transduction Protein Localization Establishment Of Localization In Cell Cellular Localization Cytoplasmic Transport Peptidyl-cysteine Methylation Vesicle-mediated Transport Regulation Of Vesicle-mediated Transport Endosomal Transport Transport Signal Transduction Antigen Processing And Presentation Signaling Cell Communication Regulation Of Exocytosis Positive Regulation Of Exocytosis Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Cellular Response To Stimulus Membrane Docking Synaptic Vesicle Transport Protein Secretion Establishment Of Organelle Localization Response To Stimulus Phagosome Maturation Organelle Localization Synaptic Vesicle Exocytosis Vesicle Docking Involved In Exocytosis Golgi Vesicle Transport Vesicle Docking Regulation Of Secretion Endocytosis Positive Regulation Of Secretion Phagolysosome Assembly Vacuole Organization Neurotransmitter Secretion Positive Regulation Of Transport Positive Regulation Of Glycoprotein Metabolic Process Regulation Of Autophagic Vacuole Assembly Regulation Of Vacuole Organization Positive Regulation Of Regulated Secretory Pathway
Tagcloud ?		accelerated anchored apposing confer directionality effectors endomembrane endosomal enigmatic exactly golgi gtpases liposomes localize master membrane organelles rab2a rab7a rabs reconstitution representative reversible strictly strikingly tethering tethers thoroughly	androgenic biometry biparental chorionic conceived conception dizygotic fetus grape homozygosity hydatidiform identifier insemination miu molar mole monospermy phm placentomegaly pmd polymorphic qf sonographic str strs terminated twinning villus zygosity
Tagcloud (Difference) ?		accelerated anchored apposing confer directionality effectors endomembrane endosomal enigmatic exactly golgi gtpases liposomes localize master membrane organelles rab2a rab7a rabs reconstitution representative reversible strictly strikingly tethering tethers thoroughly	androgenic biometry biparental chorionic conceived conception dizygotic fetus grape homozygosity hydatidiform identifier insemination miu molar mole monospermy phm placentomegaly pmd polymorphic qf sonographic str strs terminated twinning villus zygosity
Tagcloud (Intersection) ?