CHM and RAB1B

Number of citations of the paper that reports this interaction (PubMedID 9437002)
71

Data Source:
HPRD (in vivo)

		CHM	RAB1B
Description		CHM Rab escort protein	RAB1B, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Rab-protein Geranylgeranyltransferase Complex	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Endomembrane System Membrane Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Phagophore Assembly Site Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Rab Geranylgeranyltransferase Activity GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Small GTPase Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity
	Biological Process	Protein Targeting To Membrane Intracellular Protein Transport Small GTPase-mediated Signal Transduction Visual Perception Vesicle-mediated Transport Protein Geranylgeranylation	Autophagosome Assembly Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Autophagy Golgi Organization Protein Transport Virion Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Glycoprotein Metabolic Process Regulation Of Autophagosome Assembly
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Golgi Cisternae Pericentriolar Stack Reorganization Golgi Cisternae Pericentriolar Stack Reorganization COPII-mediated vesicle transport COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Choroideremia (CHM); Tapetochoroidal dystrophy
GWAS		Metabolite levels ( 23823483) Pit-and-Fissure caries ( 24556642) Smooth-surface caries ( 24556642)	Bipolar disorder ( 21926972 31043756)
Interacting Genes		11 interacting genes: RAB14 RAB18 RAB1B RAB32 RAB3A RAB3B RAB3D RAB4A RAB5B RAB6A RAB7A	12 interacting genes: APP CHM FNDC3B GDI1 GOLGA2 LINC00632 MICAL1 MICAL3 RABIF RUSC2 SMARCC2 TOMM40L
Entrez ID		1121	81876
HPRD ID		02312	11469
Ensembl ID		ENSG00000188419	ENSG00000174903
Uniprot IDs		A8K545 B4DRL9 P24386	Q9H0U4
PDB IDs			3JZA 3NKV 4HLQ 4I1O 5O74 5SZH 5SZK 6SKU 8ALK
Enriched GO Terms of Interacting Partners?		GTPase Activity GTP Binding Protein Transport Myosin V Binding Establishment Of Protein Localization GTP-dependent Protein Binding GDP Binding Hydrolase Activity Nucleotide Binding Intracellular Protein Localization Vesicle-mediated Transport G Protein Activity Secretory Granule Membrane Antigen Processing And Presentation Endomembrane System Intracellular Protein Transport Phagosome Maturation Endosome Regulation Of Vesicle-mediated Transport Establishment Of Localization In Cell Vesicle Organization Synaptic Vesicle Membrane Intracellular Transport Vesicle Golgi Apparatus Regulation Of Exocytosis Extracellular Exosome Cellular Localization Endosomal Transport Phagocytic Vesicle Positive Regulation Of Exocytosis Vesicle-mediated Transport In Synapse Retrograde Transport, Endosome To Golgi Synaptic Vesicle Recycling Membrane Perinuclear Region Of Cytoplasm Early Endosome To Golgi Transport Cytosolic Transport Synaptic Vesicle Melanosome Membrane Phagophore Assembly Site Membrane Cytoplasmic Vesicle Bone Resorption Vacuole Organization Regulation Of Transport Trans-Golgi Network Exocytosis Early Endosome Membrane Localization Within Membrane Organelle Organization	F-actin Monooxygenase Activity Small GTPase Binding Actin Filament Depolymerization Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen GDP-dissociation Inhibitor Activity Vesicle-mediated Transport Protein-containing Complex Disassembly Regulation Of Toll-like Receptor Signaling Pathway Midbody FAD Binding Protein Depolymerization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein Transport Small GTPase-mediated Signal Transduction Actin Polymerization Or Depolymerization Golgi Vesicle Transport Monooxygenase Activity Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Establishment Of Protein Localization Rab GDP-dissociation Inhibitor Activity Sulfur Oxidation Hippocampal Mossy Fiber Expansion Protein-containing Complex PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Protein-containing Complex Organization Endosome To Plasma Membrane Transport Vesicle Protein Tetramerization Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Intercellular Bridge Intracellular Signaling Cassette Post-Golgi Vesicle-mediated Transport Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Rab-protein Geranylgeranyltransferase Complex Rab Geranylgeranyltransferase Activity
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