RAB5A and SUN2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		RAB5A	SUN2
Gene Name		RAB5A, member RAS oncogene family	Sad1 and UNC84 domain containing 2
Image
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Synaptic Vesicle Endosome Membrane Actin Cytoskeleton Endocytic Vesicle Axon Dendrite Somatodendritic Compartment Melanosome Zymogen Granule Membrane Neuronal Cell Body Terminal Bouton Protein Complex Axon Terminus Membrane Raft Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Vesicular Exosome Cytoplasmic Side Of Early Endosome Membrane	Nuclear Chromosome, Telomeric Region Condensed Nuclear Chromosome Nuclear Envelope Integral Component Of Nuclear Inner Membrane Endosome Membrane Nuclear Membrane LINC Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding GDP-dissociation Inhibitor Binding	Protein Binding Lamin Binding Microtubule Binding Identical Protein Binding
	Biological Process	Intracellular Protein Transport Endocytosis Blood Coagulation Positive Regulation Of Smooth Muscle Cell Migration Regulation Of Endocytosis Rab Protein Signal Transduction Synaptic Vesicle Recycling Early Endosome To Late Endosome Transport Positive Regulation Of Exocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Endosome Size Regulation Of Filopodium Assembly Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Synaptic Vesicle Exocytosis	Nuclear Envelope Organization Mitotic Spindle Organization Nuclear Migration Positive Regulation Of Cell Migration Nuclear Migration Along Microfilament Centrosome Localization Cytoskeletal Anchoring At Nuclear Membrane Nuclear Matrix Anchoring At Nuclear Membrane
Pathways		Factors involved in megakaryocyte development and platelet production	Meiotic synapsis
Drugs
Diseases
GWAS
Protein-Protein Interactions		41 interactors: AGTR1 ALS2CL ANKFY1 AP1G1 AP1G2 APPL1 APPL2 CHM CHML EEA1 GDI2 GGA1 GGA2 GGA3 GRIK4 ITSN1 NME2 OCRL RAB37 RAB7A RABAC1 RABEP1 RABEP2 RABGGTB RASA1 RBSN RIN1 RIN2 RIN3 RIT2 RUFY1 SDCBP SGSM3 STX4 SUN2 TBC1D15 TBC1D17 TBC1D3C TBC1D3F TSC2 USP6NL	5 interactors: HGS NRM RAB5A RAB5B RPS20
Entrez ID		5868	25777
HPRD ID		01542	15611
Ensembl ID		ENSG00000144566	ENSG00000100242
Uniprot IDs		B4DJA5 P20339	B4E2A6 J3KQE0 Q9UH99
PDB IDs		1N6H 1N6I 1N6K 1N6L 1N6N 1N6O 1N6P 1N6R 1R2Q 1TU3 1TU4 3MJH	3UNP 4DXR 4DXS 4DXT 4FI9
Enriched GO Terms of Interacting Partners?		Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Positive Regulation Of Hydrolase Activity Vesicle-mediated Transport Positive Regulation Of Catalytic Activity Positive Regulation Of Ras GTPase Activity Regulation Of Ras GTPase Activity Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Regulation Of Catalytic Activity Regulation Of Ras Protein Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Small GTPase Mediated Signal Transduction Protein Transport Protein Localization Establishment Of Protein Localization Establishment Of Localization In Cell Intracellular Transport Transport Cellular Localization Endocytosis Intracellular Protein Transport Regulation Of Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Endosomal Transport Regulation Of Signaling Regulation Of Signal Transduction Membrane Organization Cellular Protein Localization Protein Geranylgeranylation Regulation Of Vesicle-mediated Transport Regulation Of Metabolic Process Vesicle Fusion Membrane Fusion Positive Regulation Of Exocytosis Protein Prenylation Regulation Of Exocytosis Organelle Fusion Golgi To Lysosome Transport Vesicle Organization Intracellular Signal Transduction Ras Protein Signal Transduction Lysosomal Transport Golgi To Vacuole Transport Plasma Membrane To Endosome Transport Cytoplasmic Transport Signaling Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion	Cytoplasmic Transport Endosomal Transport Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Cellular Protein Localization Rab Protein Signal Transduction Protein Transport Positive Regulation Of Exocytosis Establishment Of Protein Localization Intracellular Transport Protein Localization Establishment Of Localization In Cell Regulation Of Exocytosis Cellular Localization Regulation Of Endocytosis Regulation Of Endosome Size Receptor Internalization Involved In Canonical Wnt Signaling Pathway Ras Protein Signal Transduction Plasma Membrane To Endosome Transport Positive Regulation Of Secretion Establishment Of Protein Localization To Organelle Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Protein Localization To Membrane Protein Targeting To Lysosome Protein Localization To Lysosome Protein Targeting Cytoplasmic Translation Membrane Invagination Early Endosome To Late Endosome Transport Protein Localization To Organelle Protein Targeting To Vacuole Negative Regulation Of JAK-STAT Cascade Establishment Of Protein Localization To Vacuole Positive Regulation Of Smooth Muscle Cell Migration Endosome To Lysosome Transport Endosome Organization Small GTPase Mediated Signal Transduction Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Secretion Regulation Of Synaptic Vesicle Exocytosis Synaptic Vesicle Recycling Transport Regulation Of Synaptic Vesicle Transport Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Transport Receptor Internalization Lysosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Filopodium Assembly
Tagcloud ?		accelerated anchored apposing confer directionality effectors endomembrane endosomal enigmatic exactly golgi gtpases liposomes localize master membrane organelles rab2a rab7a rabs reconstitution representative reversible strictly strikingly tethering tethers thoroughly	arrangement c2c12 cardiomyopathy centrosomal connects dreifuss dystrophy edmd emery exemplified gross identifiable linc microtubule modifier muscular myonuclear myopathies myotubes ne nucleation pericentrin phenotypically positioning rearward recapitulated repositioning segregating sun1
Tagcloud (Difference) ?		accelerated anchored apposing confer directionality effectors endomembrane endosomal enigmatic exactly golgi gtpases liposomes localize master membrane organelles rab2a rab7a rabs reconstitution representative reversible strictly strikingly tethering tethers thoroughly	arrangement c2c12 cardiomyopathy centrosomal connects dreifuss dystrophy edmd emery exemplified gross identifiable linc microtubule modifier muscular myonuclear myopathies myotubes ne nucleation pericentrin phenotypically positioning rearward recapitulated repositioning segregating sun1
Tagcloud (Intersection) ?