CHM and RAB18

Number of citations of the paper that reports this interaction (PubMedID 12535645)
0

Data Source:
HPRD (two hybrid)

		CHM	RAB18
Description		CHM Rab escort protein	RAB18, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Rab-protein Geranylgeranyltransferase Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Cytosol Plasma Membrane Endomembrane System Membrane Apical Plasma Membrane Secretory Granule Membrane Cis-Golgi Network Membrane Endoplasmic Reticulum Tubular Network
	Molecular Function	Rab Geranylgeranyltransferase Activity GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Small GTPase Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding
	Biological Process	Protein Targeting To Membrane Intracellular Protein Transport Small GTPase-mediated Signal Transduction Visual Perception Vesicle-mediated Transport Protein Geranylgeranylation	Eye Development Intracellular Protein Transport Small GTPase-mediated Signal Transduction Brain Development Protein Transport Lipid Droplet Organization Endoplasmic Reticulum Tubular Network Organization
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Neutrophil degranulation COPI-independent Golgi-to-ER retrograde traffic RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Choroideremia (CHM); Tapetochoroidal dystrophy	Warburg micro syndrome
GWAS		Metabolite levels ( 23823483) Pit-and-Fissure caries ( 24556642) Smooth-surface caries ( 24556642)	A body shape index ( 34021172) Benign childhood epilepsy with centro-temporal spikes ( 32580138) Childhood ear infection ( 27182965 28928442) Diisocyanate-induced asthma ( 25918132) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 28552196) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		11 interacting genes: RAB14 RAB18 RAB1B RAB32 RAB3A RAB3B RAB3D RAB4A RAB5B RAB6A RAB7A	11 interacting genes: AQP6 CHM COPS4 ELOVL4 ERRFI1 FAM107A PDE6D PPP2R1A PPP2R1B TAX1BP1 TOM1L1
Entrez ID		1121	22931
HPRD ID		02312	03731
Ensembl ID		ENSG00000188419	ENSG00000099246
Uniprot IDs		A8K545 B4DRL9 P24386	B7Z4P9 Q9NP72
PDB IDs			1X3S
Enriched GO Terms of Interacting Partners?		GTPase Activity GTP Binding Protein Transport Myosin V Binding Establishment Of Protein Localization GTP-dependent Protein Binding GDP Binding Hydrolase Activity Nucleotide Binding Intracellular Protein Localization Vesicle-mediated Transport G Protein Activity Secretory Granule Membrane Antigen Processing And Presentation Endomembrane System Intracellular Protein Transport Phagosome Maturation Endosome Regulation Of Vesicle-mediated Transport Establishment Of Localization In Cell Vesicle Organization Synaptic Vesicle Membrane Intracellular Transport Vesicle Golgi Apparatus Regulation Of Exocytosis Extracellular Exosome Cellular Localization Endosomal Transport Phagocytic Vesicle Positive Regulation Of Exocytosis Vesicle-mediated Transport In Synapse Retrograde Transport, Endosome To Golgi Synaptic Vesicle Recycling Membrane Perinuclear Region Of Cytoplasm Early Endosome To Golgi Transport Cytosolic Transport Synaptic Vesicle Melanosome Membrane Phagophore Assembly Site Membrane Cytoplasmic Vesicle Bone Resorption Vacuole Organization Regulation Of Transport Trans-Golgi Network Exocytosis Early Endosome Membrane Localization Within Membrane Organelle Organization	Meiotic Sister Chromatid Cohesion, Centromeric Meiotic Sister Chromatid Cohesion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Protein Autophosphorylation Protein Phosphatase Type 2A Complex Small GTPase Binding Response To Glucocorticoid Response To Corticosteroid Nitrate Transmembrane Transporter Activity Meiotic Spindle Elongation Sister Chromatid Cohesion Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Protein Phosphatase Regulator Activity Regulation Of Collagen Metabolic Process Regulation Of Collagen Biosynthetic Process Response To Steroid Hormone Trehalose Metabolic Process Trehalose Catabolic Process Alpha,alpha-trehalase Activity
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