CHM and RAB14

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		CHM	RAB14
Description		CHM Rab escort protein	RAB14, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Rab-protein Geranylgeranyltransferase Complex	Golgi Membrane Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Rough Endoplasmic Reticulum Golgi Apparatus Golgi Stack Trans-Golgi Network Cytosol Plasma Membrane Cilium Endomembrane System Membrane Trans-Golgi Network Transport Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Nuclear Outer Membrane-endoplasmic Reticulum Membrane Network Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	Rab Geranylgeranyltransferase Activity GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Small GTPase Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Myosin V Binding
	Biological Process	Protein Targeting To Membrane Intracellular Protein Transport Small GTPase-mediated Signal Transduction Visual Perception Vesicle-mediated Transport Protein Geranylgeranylation	Phagolysosome Assembly Intracellular Protein Transport Golgi To Endosome Transport Fibroblast Growth Factor Receptor Signaling Pathway Protein Transport Vesicle-mediated Transport Endocytic Recycling Regulation Of Protein Localization Endosomal Vesicle Fusion Early Endosome To Golgi Transport Defense Response To Bacterium Regulation Of Embryonic Development Intracellular Transport Phagosome Maturation
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Translocation of SLC2A4 (GLUT4) to the plasma membrane Synthesis of PIPs at the plasma membrane Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Choroideremia (CHM); Tapetochoroidal dystrophy
GWAS		Metabolite levels ( 23823483) Pit-and-Fissure caries ( 24556642) Smooth-surface caries ( 24556642)	Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)
Interacting Genes		11 interacting genes: RAB14 RAB18 RAB1B RAB32 RAB3A RAB3B RAB3D RAB4A RAB5B RAB6A RAB7A	13 interacting genes: ADRB2 APP ARL8B CHM EXOC5 GARIN6 OCRL OPTN RAB11FIP5 RBSN RUFY1 SH3BP5L SMURF2
Entrez ID		1121	51552
HPRD ID		02312	06693
Ensembl ID		ENSG00000188419	ENSG00000119396
Uniprot IDs		A8K545 B4DRL9 P24386	P61106
PDB IDs			1Z0F 4D0G 4DRZ
Enriched GO Terms of Interacting Partners?		GTPase Activity GTP Binding Protein Transport Myosin V Binding Establishment Of Protein Localization GTP-dependent Protein Binding GDP Binding Hydrolase Activity Nucleotide Binding Intracellular Protein Localization Vesicle-mediated Transport G Protein Activity Secretory Granule Membrane Antigen Processing And Presentation Endomembrane System Intracellular Protein Transport Phagosome Maturation Endosome Regulation Of Vesicle-mediated Transport Establishment Of Localization In Cell Vesicle Organization Synaptic Vesicle Membrane Intracellular Transport Vesicle Golgi Apparatus Regulation Of Exocytosis Extracellular Exosome Cellular Localization Endosomal Transport Phagocytic Vesicle Positive Regulation Of Exocytosis Vesicle-mediated Transport In Synapse Retrograde Transport, Endosome To Golgi Synaptic Vesicle Recycling Membrane Perinuclear Region Of Cytoplasm Early Endosome To Golgi Transport Cytosolic Transport Synaptic Vesicle Melanosome Membrane Phagophore Assembly Site Membrane Cytoplasmic Vesicle Bone Resorption Vacuole Organization Regulation Of Transport Trans-Golgi Network Exocytosis Early Endosome Membrane Localization Within Membrane Organelle Organization	Vesicle-mediated Transport Endosome Early Endosome Membrane Early Endosome To Golgi Transport Early Endosome Small GTPase Binding Golgi Vesicle Transport Cellular Response To Amyloid-beta Response To Amyloid-beta Innate Immune Response Response To Mechanical Stimulus Positive Regulation Of CAMP/PKA Signal Transduction Golgi-associated Vesicle Defense Response To Symbiont Defense Response To Gram-negative Bacterium Protein Transport Endosomal Vesicle Fusion Cellular Localization Defense Response To Other Organism Retrograde Transport, Endosome To Golgi Platelet Alpha Granule Post-Golgi Vesicle-mediated Transport Neuronal Dense Core Vesicle Defense Response To Bacterium Lysosomal Transport Establishment Of Protein Localization Cytosolic Transport Recycling Endosome Amyloid Fibril Formation Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Ligand-gated Ion Channel Signaling Pathway Vacuolar Transport Negative Regulation Of Cell Communication Positive Regulation Of Mini Excitatory Postsynaptic Potential Negative Regulation Of Signaling Amyloid-beta Complex Regulation Of Extrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Response To Bacterium Positive Regulation Of Nitric Oxide Metabolic Process Negative Regulation Of Blood Coagulation, Common Pathway Membrane Organization Regulation Of Plasma Membrane Raft Polarization Phosphatidylinositol 3-kinase Catalytic Subunit Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?