SORBS1 and AFDN

Number of citations of the paper that reports this interaction (PubMedID 10085297)
63

Data Source:
HPRD (in vitro)

		SORBS1	AFDN
Description		sorbin and SH3 domain containing 1	afadin, adherens junction formation factor
Image
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Adherens Junction Zonula Adherens Focal Adhesion Membrane Nuclear Matrix Flotillin Complex Cell-substrate Junction Membrane Raft Anchoring Junction	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Nuclear Speck Cell Junction Cell-cell Contact Zone Pore Complex Tight Junction Anchoring Junction
	Molecular Function	Actin Binding Insulin Receptor Binding Protein Binding Cytoskeletal Protein Binding Signaling Receptor Complex Adaptor Activity	Protein Binding Small GTPase Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding
	Biological Process	Cell-matrix Adhesion Insulin Receptor Signaling Pathway Cell-substrate Adhesion Cellular Response To Insulin Stimulus Stress Fiber Assembly Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of D-glucose Import Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Focal Adhesion Assembly Positive Regulation Of Protein Localization To Plasma Membrane	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Cell Differentiation Negative Regulation Of Cell Migration Regulation Of Protein Localization Cell Junction Organization Cell-cell Adhesion Mediated By Cadherin Pore Complex Assembly Establishment Of Protein Localization To Plasma Membrane Bicellular Tight Junction Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Smooth Muscle Contraction
Drugs			(5R)-2-sulfanyl-5-[4-(trifluoromethyl)benzyl]-1,3-thiazol-4(5H)-one
Diseases
GWAS		Diabetic nephropathy in type 1 diabetes ( 25476525) Estimated glomerular filtration rate ( 31152163) Hematocrit ( 32888494) Mean platelet volume ( 32888494) Obesity-related traits ( 23251661) PR interval ( 30046033 32439900) Red blood cell count ( 32888494) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Suicide risk ( 21041247)	Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906)
Interacting Genes		31 interacting genes: ABI1 ABL1 ACTA1 ADAM15 AFDN AKT1 CBL CDK6 EFNB1 FLOT1 HUNK INPPL1 INSM1 INSR KHDRBS1 MAP4K3 PAK2 PGR PILRA PTK2 PXN RNF10 RPL4 RTN4IP1 SEMA6A SH2B2 SLC10A3 SRC SYNJ1 TENM1 VCL	39 interacting genes: BCR CTNNA1 DSCAM EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NECTIN1 NECTIN2 NECTIN3 NECTIN4 NRXN1 NRXN2 NRXN3 PFN1 PICK1 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RNF10 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG
Entrez ID		10580	4301
HPRD ID		05587	01164
Ensembl ID		ENSG00000095637	ENSG00000130396
Uniprot IDs		A0A3B3IRW8 B4DTX5 Q9BX66	A0A1P7ZIN0 A0A804HJ20 A8MQ02 G1UI22 J3KN01 P55196
PDB IDs		2DL3 2ECZ 2LJ0 2LJ1 2MOX 2O2W 2O31 2O9S 2O9V 4LN2 4LNP	1T2M 1XZ9 2AIN 2EXG 5A6C 7QCR
Enriched GO Terms of Interacting Partners?		SH2 Domain Binding Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Adhesion Regulation Of Cell-matrix Adhesion Cell-cell Junction Regulation Of Cellular Component Organization Enzyme-linked Receptor Protein Signaling Pathway Ephrin Receptor Binding Protein Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Signal Complex Assembly Cellular Response To Fluid Shear Stress Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Focal Adhesion Regulation Of Cell Motility Kinase Activity Response To Fluid Shear Stress Lamellipodium Response To Growth Factor Regulation Of Locomotion SH3 Domain Binding Vascular Endothelial Cell Response To Fluid Shear Stress Ephrin Receptor Signaling Pathway Regulation Of Cell-substrate Adhesion Cell Migration Developmental Process Protein Autophosphorylation Immune Response-activating Signaling Pathway Protein Tyrosine Kinase Activator Activity Regulation Of Organelle Organization Regulation Of Protein Phosphorylation Regulation Of Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Focal Adhesion Assembly Immune Response-regulating Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Activation Of Immune Response Cell-substrate Adhesion Regulation Of Phosphorylation Immune System Process Cell Motility Regulation Of Cell-substrate Junction Organization Fc Receptor Mediated Stimulatory Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Modification Process Cell-cell Contact Zone	Signal Transduction GDP Binding Regulation Of Cell Junction Assembly Plasma Membrane Small GTPase-mediated Signal Transduction Cell Adhesion Ras Protein Signal Transduction Cell-cell Adhesion Cell Adhesion Molecule Binding Membrane Regulation Of Synapse Assembly Adherens Junction G Protein Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Anchoring Junction Ephrin Receptor Activity Regulation Of Cell Projection Organization Transmembrane-ephrin Receptor Activity Neuron Projection Guidance Axon Guidance Protein Localization To Cell Junction GTPase Activity Plasma Membrane Bounded Cell Projection Organization Cell Junction Organization Neuroligin Family Protein Binding Synapse Regulation Of Cellular Component Organization Cell Junction Assembly Modulation Of Chemical Synaptic Transmission Regulation Of Cell Communication Regulation Of Signaling Postsynaptic Membrane Assembly Intracellular Signaling Cassette Regulation Of Synapse Organization Focal Adhesion Negative Regulation Of Cellular Component Organization Apical Junction Complex Regulation Of Locomotion Zonula Adherens Presynaptic Membrane Cell Projection Organization Postsynaptic Membrane Organization Dendrite Regulation Of Cell Projection Assembly Neuron Projection Development GTP Binding Axon Guidance Receptor Activity Cell Adhesion Mediator Activity Regulation Of Cell Motility Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
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