SORBS1 and FLOT1

Number of citations of the paper that reports this interaction (PMID 11481476)
31

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		SORBS1	FLOT1
Gene Name		sorbin and SH3 domain containing 1	flotillin 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane Insulin Receptor Complex Cell-cell Adherens Junction Zonula Adherens Cell-substrate Adherens Junction Focal Adhesion Nuclear Matrix Membrane Raft	Lysosomal Membrane Endosome Microtubule Organizing Center Caveola Focal Adhesion COP9 Signalosome Membrane Integral Component Of Membrane Flotillin Complex Centriolar Satellite Sarcolemma Melanosome Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Actin Binding SH3/SH2 Adaptor Activity Insulin Receptor Binding Protein Binding Cytoskeletal Protein Binding Protein Kinase Binding	Protease Binding Protein Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Muscle Contraction Cell-matrix Adhesion Insulin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Glucose Transport Cellular Response To Insulin Stimulus Stress Fiber Assembly Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Positive Regulation Of Lipid Biosynthetic Process Focal Adhesion Assembly Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane	Axonogenesis Extracellular Matrix Disassembly Regulation Of Rho Protein Signal Transduction Establishment Of Protein Localization To Plasma Membrane
Pathways		Smooth Muscle Contraction
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Ulcerative colitis ( 20848476)
Protein-Protein Interactions		25 interactors: ABL1 ACTA1 ADAM15 CBL CDK6 EFNB1 FLOT1 INPPL1 INSM1 INSR KHDRBS1 MAP4K3 MLLT4 PAK2 PGR PILRA PTK2 PXN RPL4 SEMA6A SH2B2 SLC10A3 SRC TENM1 VCL	16 interactors: APP ARG1 AURKB CAPN10 CBL FLOT2 FYN GOLM1 INCENP NGB PSMD4 SHBG SORBS1 SORBS2 SORBS3 SRPK1
Entrez ID		10580	10211
HPRD ID		05587	06105
Ensembl ID		ENSG00000095637	ENSG00000137312
Uniprot IDs		Q9BX66	B4DVY7 O75955 Q5ST80
PDB IDs		2DL3 2ECZ 2LJ0 2LJ1 2O2W 2O31 2O9S 2O9V
Enriched GO Terms of Interacting Partners?		Cell Development Cell Morphogenesis Involved In Differentiation Response To Stimulus Anatomical Structure Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Differentiation Anatomical Structure Morphogenesis Multicellular Organismal Development Developmental Process System Development Axonogenesis Cell Morphogenesis Signal Complex Assembly Axon Development Peptidyl-tyrosine Autophosphorylation Cell Morphogenesis Involved In Neuron Differentiation Cell Projection Organization Signal Transduction Regulation Of Cell Motility Neuron Projection Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Neuron Development Regulation Of Locomotion Regulation Of Cellular Component Movement Signaling Cell Surface Receptor Signaling Pathway Tissue Development Cell Communication Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Stimulus ERBB Signaling Pathway Nervous System Development Neuron Projection Development Regulation Of Cell Proliferation Neuron Differentiation Cell Projection Morphogenesis Cell Part Morphogenesis Generation Of Neurons Cell Adhesion Adherens Junction Organization Protein Autophosphorylation Cell-substrate Adhesion Regulation Of Cell Adhesion Axon Guidance Response To Organic Substance Neurogenesis Response To Hormone Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction	Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cell Adhesion Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Signaling Positive Regulation Of Cell Cycle Process Organelle Organization Positive Regulation Of Glucose Import Chromosome Segregation Cellular Response To Hormone Stimulus Positive Regulation Of Glucose Transport Actin Cytoskeleton Organization Cytoskeleton Organization Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Actin Filament-based Process Regulation Of L-arginine Import Primary Spermatocyte Growth Positive Regulation Of Cell Cycle Regulation Of Glucose Import Actin Filament Organization Positive Regulation Of Signal Transduction Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of ERBB Signaling Pathway Synaptic Growth At Neuromuscular Junction Type B Pancreatic Cell Apoptotic Process Developmental Cell Growth Response To Organonitrogen Compound Regulation Of Apoptotic Process Feeding Behavior Regulation Of Glucose Transport Histone H3-S28 Phosphorylation Collateral Sprouting In Absence Of Injury Negative Regulation Of Protein Metabolic Process Cytokinesis Negative Regulation Of Apoptotic Process Regulation Of Cell Death Negative Regulation Of Programmed Cell Death Spindle Stabilization Response To Hormone Nucleus Organization Apoptotic Process Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Cell Death Dendrite Development
Tagcloud ?		1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink prkg1 scd1 sfa ufa underling unraveling	anchorage archived caveolin chicken chorioallantoic constitutive downregulation electrophoretic escc esccs esophageal essc flot2 hyperactivation intermediaries inverse inversely k63 luciferase mir polyubiquitination raft rafts rip1 suppressive traf2 transwell upregulating vital
Tagcloud (Difference) ?		1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink prkg1 scd1 sfa ufa underling unraveling	anchorage archived caveolin chicken chorioallantoic constitutive downregulation electrophoretic escc esccs esophageal essc flot2 hyperactivation intermediaries inverse inversely k63 luciferase mir polyubiquitination raft rafts rip1 suppressive traf2 transwell upregulating vital
Tagcloud (Intersection) ?