SORBS1 and FLOT1

Number of citations of the paper that reports this interaction (PubMedID 11481476)
37

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		SORBS1	FLOT1
Description		sorbin and SH3 domain containing 1	flotillin 1
Image
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Adherens Junction Zonula Adherens Focal Adhesion Membrane Nuclear Matrix Flotillin Complex Cell-substrate Junction Membrane Raft Anchoring Junction	Uropod Lysosomal Membrane Endosome Early Endosome Microtubule Organizing Center Plasma Membrane Caveola Cell-cell Junction Adherens Junction Focal Adhesion COP9 Signalosome External Side Of Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Flotillin Complex Lamellipodium Cortical Actin Cytoskeleton Cytoplasmic Vesicle Centriolar Satellite Sarcolemma Melanosome Cell-cell Contact Zone Plasma Membrane Raft Membrane Raft Synapse Presynaptic Active Zone Extracellular Exosome Dopaminergic Synapse Presynapse Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Actin Binding Insulin Receptor Binding Protein Binding Cytoskeletal Protein Binding Signaling Receptor Complex Adaptor Activity	Protease Binding Protein Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Cell-matrix Adhesion Insulin Receptor Signaling Pathway Cell-substrate Adhesion Cellular Response To Insulin Stimulus Stress Fiber Assembly Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of D-glucose Import Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Focal Adhesion Assembly Positive Regulation Of Protein Localization To Plasma Membrane	Regulation Of Receptor Internalization Axonogenesis Positive Regulation Of Cell-cell Adhesion Extracellular Matrix Disassembly Positive Regulation Of Synaptic Transmission, Dopaminergic Adherens Junction Organization Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Plasma Membrane Raft Assembly Plasma Membrane Raft Organization Positive Regulation Of Endocytosis Positive Regulation Of Skeletal Muscle Tissue Development Regulation Of Neurotransmitter Uptake Caveola Assembly Protein Localization To Plasma Membrane Positive Regulation Of Myoblast Fusion Positive Regulation Of Cell Junction Assembly Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Smooth Muscle Contraction	RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Synaptic adhesion-like molecules RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs
Diseases
GWAS		Diabetic nephropathy in type 1 diabetes ( 25476525) Estimated glomerular filtration rate ( 31152163) Hematocrit ( 32888494) Mean platelet volume ( 32888494) Obesity-related traits ( 23251661) PR interval ( 30046033 32439900) Red blood cell count ( 32888494) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Suicide risk ( 21041247)	Autism spectrum disorder or schizophrenia ( 28540026) Cutaneous lupus erythematosus ( 25827949) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311) General cognitive ability ( 29844566) Handedness (non-right-handed vs right-handed) ( 31504236) Hip circumference adjusted for BMI ( 34021172) Schizophrenia ( 30285260) Sleep duration ( 25469926) Ulcerative colitis ( 20848476)
Interacting Genes		31 interacting genes: ABI1 ABL1 ACTA1 ADAM15 AFDN AKT1 CBL CDK6 EFNB1 FLOT1 HUNK INPPL1 INSM1 INSR KHDRBS1 MAP4K3 PAK2 PGR PILRA PTK2 PXN RNF10 RPL4 RTN4IP1 SEMA6A SH2B2 SLC10A3 SRC SYNJ1 TENM1 VCL	26 interacting genes: ANXA1 APP ARG1 AURKB BANP CAPN10 CBL CCDC102B COX5B FAM90A1 FLOT2 FYN GOLM1 HGS INCENP NGB NME7 PSMD4 RSPH1 SHBG SORBS1 SORBS2 SORBS3 SRPK1 UBC VHL
Entrez ID		10580	10211
HPRD ID		05587	06105
Ensembl ID		ENSG00000095637	ENSG00000137312
Uniprot IDs		A0A3B3IRW8 B4DTX5 Q9BX66	O75955 Q5ST80
PDB IDs		2DL3 2ECZ 2LJ0 2LJ1 2MOX 2O2W 2O31 2O9S 2O9V 4LN2 4LNP	9BQ2
Enriched GO Terms of Interacting Partners?		SH2 Domain Binding Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Adhesion Regulation Of Cell-matrix Adhesion Cell-cell Junction Regulation Of Cellular Component Organization Enzyme-linked Receptor Protein Signaling Pathway Ephrin Receptor Binding Protein Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Signal Complex Assembly Cellular Response To Fluid Shear Stress Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Focal Adhesion Regulation Of Cell Motility Kinase Activity Response To Fluid Shear Stress Lamellipodium Response To Growth Factor Regulation Of Locomotion SH3 Domain Binding Vascular Endothelial Cell Response To Fluid Shear Stress Ephrin Receptor Signaling Pathway Regulation Of Cell-substrate Adhesion Cell Migration Developmental Process Protein Autophosphorylation Immune Response-activating Signaling Pathway Protein Tyrosine Kinase Activator Activity Regulation Of Organelle Organization Regulation Of Protein Phosphorylation Regulation Of Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Focal Adhesion Assembly Immune Response-regulating Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Activation Of Immune Response Cell-substrate Adhesion Regulation Of Phosphorylation Immune System Process Cell Motility Regulation Of Cell-substrate Junction Organization Fc Receptor Mediated Stimulatory Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Modification Process Cell-cell Contact Zone	Flotillin Complex Protein Serine/threonine Kinase Binding Ephrin Receptor Binding Membrane Raft Growth Factor Receptor Binding Chromosome Passenger Complex Focal Adhesion Cell-substrate Junction Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Spindle Midzone Assembly Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Cytosol Regulation Of Dendritic Spine Maintenance Positive Regulation Of Mitotic Cytokinesis Spindle Midzone Assembly Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Chromocenter Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Metaphase Plate Congression Regulation Of Mitotic Cytokinesis Negative Regulation Of Type 2 Immune Response Negative Regulation Of Immune Response Positive Regulation Of Cell Cycle Checkpoint Cytoplasm Insulin Receptor Binding Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Cytoskeleton Organization Response To Platelet-derived Growth Factor Molecular Function Activator Activity Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Receptor Signaling Pathway Via STAT Cellular Response To Growth Factor Stimulus Regulation Of Cell Communication Regulation Of Signaling Amyloid Fibril Formation Positive Regulation Of Chromosome Segregation Response To Growth Factor Protein Binding Regulation Of Programmed Cell Death Regulation Of Type 2 Immune Response Positive Regulation Of Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Cell Communication Amylin Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?