SORBS1 and INSM1

Number of citations of the paper that reports this interaction (PubMedID 12079283)
31

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SORBS1	INSM1
Description		sorbin and SH3 domain containing 1	INSM transcriptional repressor 1
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GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Adherens Junction Zonula Adherens Focal Adhesion Membrane Nuclear Matrix Flotillin Complex Cell-substrate Junction Membrane Raft Anchoring Junction	Nucleus Nucleoplasm Transcription Repressor Complex
	Molecular Function	Actin Binding Insulin Receptor Binding Protein Binding Cytoskeletal Protein Binding Signaling Receptor Complex Adaptor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Zinc Ion Binding Cyclin Binding Chromatin DNA Binding Histone Deacetylase Binding Metal Ion Binding Molecular Adaptor Activity
	Biological Process	Cell-matrix Adhesion Insulin Receptor Signaling Pathway Cell-substrate Adhesion Cellular Response To Insulin Stimulus Stress Fiber Assembly Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of D-glucose Import Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Focal Adhesion Assembly Positive Regulation Of Protein Localization To Plasma Membrane	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Protein Phosphorylation Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Type B Pancreatic Cell Development Noradrenergic Neuron Development Nervous System Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Regulation Of Cell Cycle Process Cell Migration Cell Differentiation Neuron Differentiation Positive Regulation Of Cell Migration Endocrine Pancreas Development Endocrine System Development Regulation Of Cell Population Proliferation Norepinephrine Biosynthetic Process Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Differentiation Regulation Of Cell Cycle Transdifferentiation Adrenal Chromaffin Cell Differentiation Sympathetic Ganglion Development Positive Regulation Of Neural Precursor Cell Proliferation
Pathways		Smooth Muscle Contraction	Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
Drugs
Diseases
GWAS		Diabetic nephropathy in type 1 diabetes ( 25476525) Estimated glomerular filtration rate ( 31152163) Hematocrit ( 32888494) Mean platelet volume ( 32888494) Obesity-related traits ( 23251661) PR interval ( 30046033 32439900) Red blood cell count ( 32888494) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Suicide risk ( 21041247)
Interacting Genes		31 interacting genes: ABI1 ABL1 ACTA1 ADAM15 AFDN AKT1 CBL CDK6 EFNB1 FLOT1 HUNK INPPL1 INSM1 INSR KHDRBS1 MAP4K3 PAK2 PGR PILRA PTK2 PXN RNF10 RPL4 RTN4IP1 SEMA6A SH2B2 SLC10A3 SRC SYNJ1 TENM1 VCL	5 interacting genes: CCND1 KDM1A MPP3 SORBS1 TUBB3
Entrez ID		10580	3642
HPRD ID		05587	02480
Ensembl ID		ENSG00000095637	ENSG00000173404
Uniprot IDs		A0A3B3IRW8 B4DTX5 Q9BX66	Q01101
PDB IDs		2DL3 2ECZ 2LJ0 2LJ1 2MOX 2O2W 2O31 2O9S 2O9V 4LN2 4LNP	2LV2 3ZMS 8JPY 8JQ1 8K81
Enriched GO Terms of Interacting Partners?		SH2 Domain Binding Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Adhesion Regulation Of Cell-matrix Adhesion Cell-cell Junction Regulation Of Cellular Component Organization Enzyme-linked Receptor Protein Signaling Pathway Ephrin Receptor Binding Protein Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Signal Complex Assembly Cellular Response To Fluid Shear Stress Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Focal Adhesion Regulation Of Cell Motility Kinase Activity Response To Fluid Shear Stress Lamellipodium Response To Growth Factor Regulation Of Locomotion SH3 Domain Binding Vascular Endothelial Cell Response To Fluid Shear Stress Ephrin Receptor Signaling Pathway Regulation Of Cell-substrate Adhesion Cell Migration Developmental Process Protein Autophosphorylation Immune Response-activating Signaling Pathway Protein Tyrosine Kinase Activator Activity Regulation Of Organelle Organization Regulation Of Protein Phosphorylation Regulation Of Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Focal Adhesion Assembly Immune Response-regulating Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Activation Of Immune Response Cell-substrate Adhesion Regulation Of Phosphorylation Immune System Process Cell Motility Regulation Of Cell-substrate Junction Organization Fc Receptor Mediated Stimulatory Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Modification Process Cell-cell Contact Zone	Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Transcription Corepressor Activity Response To UV Re-entry Into Mitotic Cell Cycle Response To Ionizing Radiation Cyclin D1-CDK4 Complex Cyclin D1-CDK6 Complex Adherens Junction Netrin Receptor Binding Dorsal Root Ganglion Development Response To Fungicide MRF Binding Guanine Metabolic Process Protein Demethylase Activity Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling
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