SORBS1 and EFNB1

Number of citations of the paper that reports this interaction (PubMedID 11557983)
0

Data Source:
HPRD (in vivo)

		SORBS1	EFNB1
Description		sorbin and SH3 domain containing 1	ephrin B1
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GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Adherens Junction Zonula Adherens Focal Adhesion Membrane Nuclear Matrix Flotillin Complex Cell-substrate Junction Membrane Raft Anchoring Junction	Nucleus Cytoplasm Plasma Membrane Cell Surface Membrane Presynaptic Membrane Membrane Raft Synapse Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Actin Binding Insulin Receptor Binding Protein Binding Cytoskeletal Protein Binding Signaling Receptor Complex Adaptor Activity	Protein Binding Ephrin Receptor Binding
	Biological Process	Cell-matrix Adhesion Insulin Receptor Signaling Pathway Cell-substrate Adhesion Cellular Response To Insulin Stimulus Stress Fiber Assembly Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of D-glucose Import Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Focal Adhesion Assembly Positive Regulation Of Protein Localization To Plasma Membrane	Neural Crest Cell Migration Cell Adhesion Cell-cell Signaling Nervous System Development Axon Guidance Embryonic Pattern Specification Cell Differentiation T Cell Costimulation T Cell Proliferation Positive Regulation Of T Cell Proliferation Ephrin Receptor Signaling Pathway Regulation Of Autophagosome Assembly
Pathways		Smooth Muscle Contraction	EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs
Diseases			Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS		Diabetic nephropathy in type 1 diabetes ( 25476525) Estimated glomerular filtration rate ( 31152163) Hematocrit ( 32888494) Mean platelet volume ( 32888494) Obesity-related traits ( 23251661) PR interval ( 30046033 32439900) Red blood cell count ( 32888494) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Suicide risk ( 21041247)
Interacting Genes		31 interacting genes: ABI1 ABL1 ACTA1 ADAM15 AFDN AKT1 CBL CDK6 EFNB1 FLOT1 HUNK INPPL1 INSM1 INSR KHDRBS1 MAP4K3 PAK2 PGR PILRA PTK2 PXN RNF10 RPL4 RTN4IP1 SEMA6A SH2B2 SLC10A3 SRC SYNJ1 TENM1 VCL	17 interacting genes: ANKRD46 CAPN10 CUL3 EPHA3 EPHB1 EPHB2 GRIP1 MYC NCK2 PICK1 PTPN13 RGS3 SDCBP SORBS1 SRC TIAM1 YWHAQ
Entrez ID		10580	1947
HPRD ID		05587	02072
Ensembl ID		ENSG00000095637	ENSG00000090776
Uniprot IDs		A0A3B3IRW8 B4DTX5 Q9BX66	P98172
PDB IDs		2DL3 2ECZ 2LJ0 2LJ1 2MOX 2O2W 2O31 2O9S 2O9V 4LN2 4LNP	6THG
Enriched GO Terms of Interacting Partners?		SH2 Domain Binding Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Adhesion Regulation Of Cell-matrix Adhesion Cell-cell Junction Regulation Of Cellular Component Organization Enzyme-linked Receptor Protein Signaling Pathway Ephrin Receptor Binding Protein Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Signal Complex Assembly Cellular Response To Fluid Shear Stress Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Focal Adhesion Regulation Of Cell Motility Kinase Activity Response To Fluid Shear Stress Lamellipodium Response To Growth Factor Regulation Of Locomotion SH3 Domain Binding Vascular Endothelial Cell Response To Fluid Shear Stress Ephrin Receptor Signaling Pathway Regulation Of Cell-substrate Adhesion Cell Migration Developmental Process Protein Autophosphorylation Immune Response-activating Signaling Pathway Protein Tyrosine Kinase Activator Activity Regulation Of Organelle Organization Regulation Of Protein Phosphorylation Regulation Of Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Focal Adhesion Assembly Immune Response-regulating Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Activation Of Immune Response Cell-substrate Adhesion Regulation Of Phosphorylation Immune System Process Cell Motility Regulation Of Cell-substrate Junction Organization Fc Receptor Mediated Stimulatory Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Modification Process Cell-cell Contact Zone	Ephrin Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Transmembrane-ephrin Receptor Activity Ephrin Receptor Activity Dendritic Spine Development Regulation Of Organelle Organization Regulation Of Cell Communication Regulation Of Signaling Enzyme-linked Receptor Protein Signaling Pathway Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Regulation Of Cell Junction Assembly Dendritic Spine Organization Signaling Receptor Complex Adaptor Activity Cell Recognition Protein Tyrosine Kinase Activity Optic Nerve Morphogenesis Hindbrain Tangential Cell Migration Neuron Projection Organization Postsynapse Organization Signal Transduction Cell Migration Cell-substrate Adhesion Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cell Projection Organization Plasma Membrane Cytosol Regulation Of Signal Transduction Cellular Response To Peptide Hormone Stimulus Signal Complex Assembly Phosphorylation Actin Filament Bundle Assembly Cell Surface Receptor Signaling Pathway Cell Motility Positive Regulation Of Protein Localization To Plasma Membrane Actin Filament Bundle Organization Regulation Of Intracellular Signal Transduction Negative Regulation Of Cellular Component Organization Cell Projection Organization Membrane Raft Axon Guidance Receptor Activity Fibroblast Apoptotic Process Positive Regulation Of Protein Localization Positive Regulation Of Protein Localization To Cell Periphery Cell Migration In Hindbrain Positive Regulation Of Protein Localization To Membrane
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