SORBS1 and SLC10A3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SORBS1	SLC10A3
Description		sorbin and SH3 domain containing 1	solute carrier family 10 member 3
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Adherens Junction Zonula Adherens Focal Adhesion Membrane Nuclear Matrix Flotillin Complex Cell-substrate Junction Membrane Raft Anchoring Junction	Membrane
	Molecular Function	Actin Binding Insulin Receptor Binding Protein Binding Cytoskeletal Protein Binding Signaling Receptor Complex Adaptor Activity	Bile Acid:sodium Symporter Activity Symporter Activity
	Biological Process	Cell-matrix Adhesion Insulin Receptor Signaling Pathway Cell-substrate Adhesion Cellular Response To Insulin Stimulus Stress Fiber Assembly Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of D-glucose Import Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Focal Adhesion Assembly Positive Regulation Of Protein Localization To Plasma Membrane	Bile Acid And Bile Salt Transport Response To Retinoic Acid Transmembrane Transport
Pathways		Smooth Muscle Contraction
Drugs
Diseases
GWAS		Diabetic nephropathy in type 1 diabetes ( 25476525) Estimated glomerular filtration rate ( 31152163) Hematocrit ( 32888494) Mean platelet volume ( 32888494) Obesity-related traits ( 23251661) PR interval ( 30046033 32439900) Red blood cell count ( 32888494) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Suicide risk ( 21041247)
Interacting Genes		31 interacting genes: ABI1 ABL1 ACTA1 ADAM15 AFDN AKT1 CBL CDK6 EFNB1 FLOT1 HUNK INPPL1 INSM1 INSR KHDRBS1 MAP4K3 PAK2 PGR PILRA PTK2 PXN RNF10 RPL4 RTN4IP1 SEMA6A SH2B2 SLC10A3 SRC SYNJ1 TENM1 VCL	1 interacting genes: SORBS1
Entrez ID		10580	8273
HPRD ID		05587	02418
Ensembl ID		ENSG00000095637	ENSG00000126903
Uniprot IDs		A0A3B3IRW8 B4DTX5 Q9BX66	A0A0A0MS43 P09131
PDB IDs		2DL3 2ECZ 2LJ0 2LJ1 2MOX 2O2W 2O31 2O9S 2O9V 4LN2 4LNP
Enriched GO Terms of Interacting Partners?		SH2 Domain Binding Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Adhesion Regulation Of Cell-matrix Adhesion Cell-cell Junction Regulation Of Cellular Component Organization Enzyme-linked Receptor Protein Signaling Pathway Ephrin Receptor Binding Protein Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Signal Complex Assembly Cellular Response To Fluid Shear Stress Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Focal Adhesion Regulation Of Cell Motility Kinase Activity Response To Fluid Shear Stress Lamellipodium Response To Growth Factor Regulation Of Locomotion SH3 Domain Binding Vascular Endothelial Cell Response To Fluid Shear Stress Ephrin Receptor Signaling Pathway Regulation Of Cell-substrate Adhesion Cell Migration Developmental Process Protein Autophosphorylation Immune Response-activating Signaling Pathway Protein Tyrosine Kinase Activator Activity Regulation Of Organelle Organization Regulation Of Protein Phosphorylation Regulation Of Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Focal Adhesion Assembly Immune Response-regulating Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Activation Of Immune Response Cell-substrate Adhesion Regulation Of Phosphorylation Immune System Process Cell Motility Regulation Of Cell-substrate Junction Organization Fc Receptor Mediated Stimulatory Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Modification Process Cell-cell Contact Zone	Signaling Receptor Complex Adaptor Activity Positive Regulation Of Glucose Metabolic Process Focal Adhesion Assembly Cell-substrate Junction Organization Positive Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Insulin Receptor Signaling Pathway Zonula Adherens Contractile Actin Filament Bundle Assembly Positive Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Biosynthetic Process Positive Regulation Of D-glucose Import Stress Fiber Assembly Positive Regulation Of D-glucose Transmembrane Transport Cell-substrate Junction Insulin Receptor Binding Flotillin Complex Regulation Of Glycogen Metabolic Process Cell-substrate Junction Assembly Cytoskeletal Protein Binding Actin Filament Bundle Organization Positive Regulation Of Protein Localization To Cell Periphery Insulin Receptor Signaling Pathway Regulation Of D-glucose Transmembrane Transport Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Actin Filament Bundle Assembly Regulation Of D-glucose Import Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Membrane Stress Fiber Positive Regulation Of Lipid Biosynthetic Process Cellular Response To Insulin Stimulus Regulation Of Glucose Metabolic Process Cell-matrix Adhesion Actomyosin Structure Organization Regulation Of Protein Localization To Plasma Membrane Nuclear Matrix Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Lipid Metabolic Process Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Small Molecule Metabolic Process Cell-substrate Adhesion Response To Insulin Cellular Response To Peptide Hormone Stimulus Regulation Of Protein Localization To Membrane Adherens Junction Regulation Of Lipid Biosynthetic Process Membrane Raft Actin Filament Organization Cell Junction Assembly
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