SORBS1 and INPPL1

Number of citations of the paper that reports this interaction (PubMedID 12504111)
0

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SORBS1	INPPL1
Description		sorbin and SH3 domain containing 1	inositol polyphosphate phosphatase like 1
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GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Adherens Junction Zonula Adherens Focal Adhesion Membrane Nuclear Matrix Flotillin Complex Cell-substrate Junction Membrane Raft Anchoring Junction	Spindle Pole Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Basal Plasma Membrane Membrane Nuclear Speck Lamellipodium Filopodium Cell Projection
	Molecular Function	Actin Binding Insulin Receptor Binding Protein Binding Cytoskeletal Protein Binding Signaling Receptor Complex Adaptor Activity	Actin Binding Inositol-polyphosphate 5-phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity SH3 Domain Binding Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity SH2 Domain Binding
	Biological Process	Cell-matrix Adhesion Insulin Receptor Signaling Pathway Cell-substrate Adhesion Cellular Response To Insulin Stimulus Stress Fiber Assembly Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of D-glucose Import Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Focal Adhesion Assembly Positive Regulation Of Protein Localization To Plasma Membrane	Establishment Of Mitotic Spindle Orientation Endochondral Ossification Immune System Process Glucose Metabolic Process Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Endocytosis Apoptotic Process Actin Filament Organization Cell Adhesion Negative Regulation Of Cell Population Proliferation Post-embryonic Development Gene Expression Negative Regulation Of Gene Expression Response To Insulin Regulation Of Protein Localization Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol Dephosphorylation Regulation Of Immune Response ERK1 And ERK2 Cascade Ruffle Assembly Regulation Of Actin Filament Organization
Pathways		Smooth Muscle Contraction	Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Interleukin receptor SHC signaling Signaling by CSF1 (M-CSF) in myeloid cells
Drugs
Diseases
GWAS		Diabetic nephropathy in type 1 diabetes ( 25476525) Estimated glomerular filtration rate ( 31152163) Hematocrit ( 32888494) Mean platelet volume ( 32888494) Obesity-related traits ( 23251661) PR interval ( 30046033 32439900) Red blood cell count ( 32888494) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Suicide risk ( 21041247)	Heart rate response to recovery post exercise (10 sec) ( 29497042)
Interacting Genes		31 interacting genes: ABI1 ABL1 ACTA1 ADAM15 AFDN AKT1 CBL CDK6 EFNB1 FLOT1 HUNK INPPL1 INSM1 INSR KHDRBS1 MAP4K3 PAK2 PGR PILRA PTK2 PXN RNF10 RPL4 RTN4IP1 SEMA6A SH2B2 SLC10A3 SRC SYNJ1 TENM1 VCL	23 interacting genes: ABL1 AR ARAP3 BCAR1 CBL CD4 CSF1R EGFR ERBB2 ERBB3 ERBB4 FCGR2B FLNC GAB1 HID1 LNCAROD MET PLEK2 SHC1 SORBS1 SORBS3 SRC UBC
Entrez ID		10580	3636
HPRD ID		05587	02900
Ensembl ID		ENSG00000095637	ENSG00000165458
Uniprot IDs		A0A3B3IRW8 B4DTX5 Q9BX66	O15357
PDB IDs		2DL3 2ECZ 2LJ0 2LJ1 2MOX 2O2W 2O31 2O9S 2O9V 4LN2 4LNP	2K4P 2KSO 2MK2 3NR8 4A9C 5OKM 5OKN 5OKO 5OKP 6SQU 6SRR
Enriched GO Terms of Interacting Partners?		SH2 Domain Binding Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Adhesion Regulation Of Cell-matrix Adhesion Cell-cell Junction Regulation Of Cellular Component Organization Enzyme-linked Receptor Protein Signaling Pathway Ephrin Receptor Binding Protein Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Signal Complex Assembly Cellular Response To Fluid Shear Stress Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Focal Adhesion Regulation Of Cell Motility Kinase Activity Response To Fluid Shear Stress Lamellipodium Response To Growth Factor Regulation Of Locomotion SH3 Domain Binding Vascular Endothelial Cell Response To Fluid Shear Stress Ephrin Receptor Signaling Pathway Regulation Of Cell-substrate Adhesion Cell Migration Developmental Process Protein Autophosphorylation Immune Response-activating Signaling Pathway Protein Tyrosine Kinase Activator Activity Regulation Of Organelle Organization Regulation Of Protein Phosphorylation Regulation Of Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Focal Adhesion Assembly Immune Response-regulating Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Activation Of Immune Response Cell-substrate Adhesion Regulation Of Phosphorylation Immune System Process Cell Motility Regulation Of Cell-substrate Junction Organization Fc Receptor Mediated Stimulatory Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Modification Process Cell-cell Contact Zone	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Protein Tyrosine Kinase Activity Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus ERBB2 Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Response To Growth Factor Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Focal Adhesion Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Negative Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Apoptotic Process Signal Transduction Basal Plasma Membrane Ephrin Receptor Binding Plasma Membrane Animal Organ Development Regulation Of Cellular Component Organization Receptor Complex Positive Regulation Of Cell Population Proliferation Protein Kinase Activity Positive Regulation Of Macromolecule Biosynthetic Process Neuron Differentiation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Biosynthetic Process Positive Regulation Of Protein Phosphorylation Regulation Of Cell Population Proliferation Positive Regulation Of Phosphorylation Protein Tyrosine Kinase Activator Activity Shc-EGFR Complex ERBB3:ERBB2 Complex Kinase Activity Intracellular Signal Transduction
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