PEX12 and C5orf46

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PEX12	C5orf46
Description		peroxisomal biogenesis factor 12	chromosome 5 open reading frame 46
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Peroxisome Peroxisomal Membrane Cytosol Membrane Peroxisomal Importomer Complex	Extracellular Region Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Transmembrane Transporter Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin Ligase Activator Activity	Protein Binding
	Biological Process	Protein Polyubiquitination Pexophagy Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Protein Targeting To Peroxisome Peroxisome Organization Protein Transport Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Ubiquitination Cellular Response To Reactive Oxygen Species Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Unfolding Protein Import Into Peroxisome Matrix, Substrate Release
Pathways		E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import
Drugs
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Alcoholic chronic pancreatitis ( 28754779)
Interacting Genes		36 interacting genes: ACSL5 ADIPOQ BNIP2 BTN2A2 C5orf46 CLDN10 COL8A2 CXCL16 CYBC1 DNAJC30 ERMP1 FA2H FKBP8 FXYD6 GJB2 IER3IP1 MARCHF2 MGLL NKG7 NRM PEX10 PEX19 PEX5 PNLIPRP1 PTPN9 RBFA SEC22A SEC61G SMCO4 SRGN STX8 THSD7B TMEM11 TMEM222 TREX1 TTPA	12 interacting genes: AQP6 EBP FAM210B LHFPL5 PEX12 RUSF1 SGTA SGTB SLC30A2 TBXA2R TIMMDC1 TMEM80
Entrez ID		5193	389336
HPRD ID		03455	14491
Ensembl ID		ENSG00000108733	ENSG00000178776
Uniprot IDs		O00623	Q6UWT4
PDB IDs
Enriched GO Terms of Interacting Partners?		Peroxisomal Membrane Transport Establishment Of Protein Localization To Peroxisome Peroxisome Membrane Targeting Sequence Binding Endoplasmic Reticulum Membrane Membrane Peroxisome Organization Intracellular Protein Transmembrane Transport Fatty Acid Metabolic Process Endoplasmic Reticulum Protein Import Into Peroxisome Matrix, Substrate Release Protein Import Into Peroxisome Membrane Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Targeting To Peroxisome Protein Carrier Chaperone Cytolytic Granule Granzyme-mediated Programmed Cell Death Signaling Pathway Protein Unfolding Peroxisomal Membrane Protein Import Into Peroxisome Matrix Monocarboxylic Acid Metabolic Process Protein Transmembrane Transport Pexophagy Triglyceride Catabolic Process Response To Oxidative Stress Cellular Response To Oxidative Stress Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Protein Transmembrane Transporter Activity Receptor Recycling Cellular Response To Reactive Oxygen Species Fatty Acid Biosynthetic Process Acylglycerol Catabolic Process Lipid Catabolic Process Maintenance Of Granzyme B Location In T Cell Secretory Granule Maintenance Of Protease Location In Mast Cell Secretory Granule T Cell Secretory Granule Organization Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Membrane Organization Negative Regulation Of Establishment Of Blood-brain Barrier Negative Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Renal Albumin Absorption Positive Regulation Of Metanephric Podocyte Development Positive Regulation Of Glycogen (starch) Synthase Activity Immune Complex Formation Adenyl Deoxyribonucleotide Binding Immune Response In Brain Or Nervous System Ssh1 Translocon Complex 4-hydroxysphinganine Ceramide Fatty Acyl 2-hydroxylase Activity Free Fatty Acid 2-hydroxylase Activity Fatty Acid 2-hydroxylase Activity	TRC Complex Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Nitrate Transmembrane Transporter Activity Protein Targeting Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle Cholesterol-5,6-oxide Hydrolase Activity Protein Targeting To Membrane PH-gated Chloride Channel Activity Nitrate Transmembrane Transport C-8 Sterol Isomerase Activity Cholestenol Delta-isomerase Activity Establishment Of Protein Localization To Organelle Peroxisomal Importomer Complex Zinc Export Across Plasma Membrane Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol Steroid Delta-isomerase Activity BAT3 Complex Binding Zinc Ion Import Into Lysosome Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Zinc:proton Antiporter Activity
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