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UTP14A and RPA2
Number of citations of the paper that reports this interaction (PubMedID
37827155
)
181
Data Source:
BioGRID
(two hybrid, proximity labelling technology)
HPRD
(two hybrid)
UTP14A
RPA2
Description
UTP14A small subunit processome component
replication protein A2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytosol
Small-subunit Processome
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
Nuclear Body
PML Body
Site Of Double-strand Break
Molecular Function
RNA Binding
Protein Binding
DNA Binding
Damaged DNA Binding
Single-stranded DNA Binding
Protein Binding
Enzyme Binding
Protein Phosphatase Binding
Ubiquitin Protein Ligase Binding
Telomeric DNA Binding
G-rich Strand Telomeric DNA Binding
Biological Process
RRNA Processing
Ribosome Biogenesis
DNA Damage Checkpoint Signaling
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Replication
DNA Repair
Base-excision Repair
Nucleotide-excision Repair
Mismatch Repair
DNA Recombination
DNA Damage Response
Regulation Of Double-strand Break Repair Via Homologous Recombination
Mitotic G1 DNA Damage Checkpoint Signaling
Protein Localization To Chromosome
Regulation Of DNA Damage Checkpoint
Pathways
rRNA modification in the nucleus and cytosol
Major pathway of rRNA processing in the nucleolus and cytosol
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Removal of the Flap Intermediate from the C-strand
Activation of ATR in response to replication stress
Regulation of HSF1-mediated heat shock response
HSF1 activation
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Regulation of TP53 Activity through Phosphorylation
Activation of the pre-replicative complex
Removal of the Flap Intermediate
G2/M DNA damage checkpoint
Meiotic recombination
Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS
HDL cholesterol levels (
32203549
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
White blood cell count (
32888494
)
Interacting Genes
54 interacting genes:
AKTIP
APLP1
APP
ARIH2
AXIN1
BICD2
CCDC106
CCDC85B
CEP70
CPE
CSNK2A1
CSNK2B
DLEU1
EXOSC8
GADD45G
HNRNPH3
HOOK1
HOOK2
HTT
KRT31
LAMTOR5
LDOC1
LMO1
LSM3
NIN
NINL
PDCD5
PDZK1IP1
PHF10
PRKCZ
PSG1
PTEN
PTPRS
RABIF
RGS1
RHOH
RNF10
RPA2
RSRC1
SAT1
SMYD1
SNRNP48
SSR1
TERF1
TFIP11
TINAGL1
TP53
TP53BP2
TRDMT1
TXLNB
USO1
VIM
WDR33
ZNF24
69 interacting genes:
ACP5
AKAP9
APP
ATM
CALCOCO2
CASK
CCNC
CCNO
CDK1
CEBPA
CEP126
CFB
COPS6
CRMP1
DMRTB1
EEF1A1
ERCC1
ERCC4
EXOSC7
GAPDH
GOLM1
HERPUD1
HIRA
HNRNPUL1
HUS1
LNX2
LRIF1
MARK2
MCM2
MCM5
MED31
MEN1
NDEL1
ORC1
ORC2
ORC5
PCM1
PIAS1
PIAS4
PRC1
PRKDC
RAD1
RAD51
RAD52
RAD9A
RBM14
RBM48
RNF20
RNF40
RPA1
RPA3
RPLP1
SDF4
SERTAD3
SF1
SLC17A9
SMARCAL1
STAT3
TLE1
TP53
TUBB2A
UNC119
UNG
UTP14A
WAS
WRN
XPA
YWHAE
ZBTB14
Entrez ID
10813
6118
HPRD ID
06712
01566
Ensembl ID
ENSG00000156697
ENSG00000117748
Uniprot IDs
Q9BVJ6
B4DUL2
P15927
PDB IDs
7MQ8
7MQ9
7MQA
7WTS
1DPU
1L1O
1QUQ
1Z1D
2PI2
2PQA
2Z6K
3KDF
4MQV
4OU0
8RK2
9MJ5
Enriched GO Terms of Interacting Partners
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FHF Complex
Protein Localization To Perinuclear Region Of Cytoplasm
Microtubule Cytoskeleton Organization
Microtubule Anchoring At Microtubule Organizing Center
HOPS Complex
MRNA Metabolic Process
Identical Protein Binding
Protein Kinase CK2 Complex
Symbiont-mediated Disruption Of Host Cell PML Body
PML Body
Cellular Response To Norepinephrine Stimulus
Response To Norepinephrine
Cellular Localization
Organelle Organization
Microtubule Anchoring
Early Endosome To Late Endosome Transport
P53 Binding
Dynein Light Intermediate Chain Binding
Apoptotic Process
Positive Regulation Of Aggrephagy
Central Nervous System Development
Cytoplasm
Programmed Cell Death
Cell Death
Positive Regulation Of Excitatory Postsynaptic Potential
Fibrillar Center
Microtubule-based Process
Cytoskeleton Organization
Microtubule Organizing Center
Intracellular Transport
Nucleus
Cytoskeleton-dependent Intracellular Transport
G-rich Strand Telomeric DNA Binding
Cellular Response To Muramyl Dipeptide
Modulation Of Excitatory Postsynaptic Potential
Developmental Cell Growth
Microtubule Anchoring At Centrosome
Regulation Of Nervous System Process
Endosome To Lysosome Transport
Nuclear Matrix
Supramolecular Fiber Organization
Negative Regulation Of DNA Metabolic Process
Negative Regulation Of Cell Cycle
Negative Regulation Of Neurogenesis
Centrosome
Nucleoplasm
Dynactin Binding
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Nervous System Development
Cytoplasmic Microtubule Organization
DNA Metabolic Process
DNA Repair
Chromosome, Telomeric Region
Double-strand Break Repair
Nucleic Acid Metabolic Process
Nucleobase-containing Compound Metabolic Process
Nucleoplasm
DNA Damage Response
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
DNA Recombination
Macromolecule Metabolic Process
Response To Radiation
Nucleus
Telomere Maintenance
Response To Ionizing Radiation
Cellular Response To Stress
Cellular Response To Radiation
Nucleotide-excision Repair
Telomere Organization
DNA Replication Origin Binding
Site Of Double-strand Break
DNA Replication
Regulation Of DNA Metabolic Process
Damaged DNA Binding
Chromosome Organization
Single-stranded DNA Binding
Mitotic DNA Integrity Checkpoint Signaling
Nuclear Origin Of Replication Recognition Complex
Cellular Response To Ionizing Radiation
Regulation Of Cell Cycle
Response To Light Stimulus
Nucleotide-excision Repair Factor 1 Complex
Response To Gamma Radiation
DNA Replication Initiation
Response To Stress
Regulation Of Primary Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
UV Protection
Negative Regulation Of Cell Cycle
DNA Damage Checkpoint Signaling
DNA Replication Factor A Complex
Regulation Of Cellular Response To Stress
Response To UV
PML Body
Replicative Senescence
Mitotic DNA Damage Checkpoint Signaling
Base-excision Repair
Checkpoint Clamp Complex
Regulation Of Macromolecule Metabolic Process
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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