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UTP14A and RPA2
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
UTP14A
RPA2
Gene Name
UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
replication protein A2, 32kDa
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleolus
Small-subunit Processome
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
PML Body
Site Of Double-strand Break
Molecular Function
Protein Binding
Poly(A) RNA Binding
Damaged DNA Binding
Single-stranded DNA Binding
Protein Binding
Enzyme Binding
Protein Phosphatase Binding
Ubiquitin Protein Ligase Binding
Protein N-terminus Binding
Biological Process
Maturation Of SSU-rRNA
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Nucleotide-excision Repair, DNA Damage Removal
Telomere Maintenance Via Recombination
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Recombinase Assembly
DNA Replication
DNA Strand Elongation Involved In DNA Replication
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Nucleotide-excision Repair
Nucleotide-excision Repair, DNA Gap Filling
Mismatch Repair
Double-strand Break Repair
Regulation Of Double-strand Break Repair Via Homologous Recombination
Mitotic G1 DNA Damage Checkpoint
Telomere Maintenance Via Semi-conservative Replication
Cellular Response To Heat
Regulation Of Cellular Response To Heat
Regulation Of DNA Damage Checkpoint
Pathways
HSF1 activation
Gap-filling DNA repair synthesis and ligation in TC-NER
G2/M Checkpoints
Repair synthesis for gap-filling by DNA polymerase in TC-NER
Activation of the pre-replicative complex
DNA strand elongation
Mismatch Repair
G1/S Transition
Homologous recombination repair of replication-independent double-strand breaks
Mitotic G1-G1/S phases
Removal of the Flap Intermediate from the C-strand
Chromosome Maintenance
DNA Replication Pre-Initiation
S Phase
Removal of the Flap Intermediate
Global Genomic NER (GG-NER)
Nucleotide Excision Repair
Activation of the pre-replicative complex
Extension of Telomeres
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Assembly of the RAD51-ssDNA nucleoprotein complex
Telomere Maintenance
Activation of ATR in response to replication stress
Processing of DNA double-strand break ends
Double-Strand Break Repair
Dual incision reaction in GG-NER
Meiotic recombination
Synthesis of DNA
Lagging Strand Synthesis
Processive synthesis on the C-strand of the telomere
Processive synthesis on the lagging strand
M/G1 Transition
Cellular response to heat stress
Regulation of HSF1-mediated heat shock response
Telomere C-strand (Lagging Strand) Synthesis
Presynaptic phase of homologous DNA pairing and strand exchange
Repair synthesis of patch ~27-30 bases long by DNA polymerase
Cell Cycle, Mitotic
Gap-filling DNA repair synthesis and ligation in GG-NER
Homologous DNA pairing and strand exchange
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Transcription-coupled NER (TC-NER)
Homologous Recombination Repair
Formation of incision complex in GG-NER
Cell Cycle Checkpoints
Drugs
Diseases
GWAS
Protein-Protein Interactions
43 interactors:
AKTIP
APLP1
ARIH2
AXIN1
CCDC106
CCDC85B
CEP70
CPE
CSNK2A1
CSNK2B
DLEU1
GADD45G
HNRNPH3
HOOK2
HTT
LAMTOR5
LDOC1
LSM3
NINL
PDCD5
PDZK1IP1
PHF10
PRKCZ
PSG1
PTEN
PTPRS
RABIF
RGS1
RHOH
RNF10
RPA2
RSRC1
SAT1
SMYD1
SSR1
TERF1
TINAGL1
TP53
TP53BP2
TRDMT1
VIM
WDR33
ZNF24
49 interactors:
ACP5
APP
ATM
CALCOCO2
CCNO
CDC5L
CDK1
CFB
COPS6
CRMP1
EEF1A1
EIF4G2
GAPDH
GOLM1
HERPUD1
HNRNPUL1
HUS1
KIAA1377
LRIF1
MCM2
MCM3
MCM4
MCM5
MED31
MEN1
ORC1
ORC2
ORC4
ORC5
PRKDC
PRPF19
RAD1
RAD52
RAD9A
RBM48
RFWD3
RPA1
RPA3
RPLP1
SDF4
SERTAD3
SLC17A9
STAT3
TLE1
TUBB2A
UNC119
UNG
UTP14A
XPA
Entrez ID
10813
6118
HPRD ID
06712
01566
Ensembl ID
ENSG00000156697
ENSG00000117748
Uniprot IDs
F8WD00
Q9BVJ6
P15927
PDB IDs
1DPU
1L1O
1QUQ
1Z1D
2PI2
2PQA
2Z6K
3KDF
Enriched GO Terms of Interacting Partners
?
Apoptotic Process
Programmed Cell Death
Cell Death
Death
Developmental Process
Regulation Of Catalytic Activity
Mitotic Cell Cycle
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Signal Transduction
Regulation Of Cellular Protein Metabolic Process
Nervous System Development
System Development
Mitotic Cell Cycle Process
Multicellular Organismal Development
Regulation Of Phosphorus Metabolic Process
Regulation Of Cell Proliferation
Positive Regulation Of Protein Metabolic Process
Anatomical Structure Development
Regulation Of Protein Metabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Negative Regulation Of Mitotic Cell Cycle
Negative Regulation Of Catalytic Activity
Regulation Of Cell Cycle Phase Transition
Regulation Of Metabolic Process
Cell Cycle
Positive Regulation Of Metabolic Process
Response To Stimulus
Positive Regulation Of Cellular Protein Metabolic Process
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Regulation Of Mitotic Sister Chromatid Separation
Negative Regulation Of Protein Metabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Cell Cycle
Regulation Of Mitotic Metaphase/anaphase Transition
Positive Regulation Of Protein Modification Process
Negative Regulation Of Cell Proliferation
Negative Regulation Of Neurogenesis
Regulation Of Cell Cycle
Cytoplasmic Transport
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Protein Phosphorylation
Mitotic Cell Cycle Checkpoint
Central Nervous System Development
Negative Regulation Of Cell Differentiation
Cell Differentiation
Negative Regulation Of Cell Development
Regulation Of Phosphorylation
Neurotransmitter Uptake
DNA Metabolic Process
Cell Cycle Process
Cell Cycle
DNA Replication
Heterocycle Metabolic Process
DNA Replication Initiation
Mitotic Cell Cycle Process
Nucleobase-containing Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Mitotic Cell Cycle
Cellular Aromatic Compound Metabolic Process
DNA-dependent DNA Replication
DNA Repair
G1/S Transition Of Mitotic Cell Cycle
Nitrogen Compound Metabolic Process
Cellular Response To DNA Damage Stimulus
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
DNA Damage Checkpoint
DNA Strand Elongation Involved In DNA Replication
DNA Strand Elongation
Cellular Response To Stress
Cell Cycle Checkpoint
Response To Radiation
Cellular Metabolic Process
Negative Regulation Of Cell Cycle
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Response To Stress
Biosynthetic Process
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Response To Ionizing Radiation
Double-strand Break Repair
Regulation Of Cell Cycle
DNA Recombinase Assembly
Response To Abiotic Stimulus
DNA Recombination
DNA Catabolic Process
Cellular Macromolecule Catabolic Process
Mitotic Cell Cycle Checkpoint
Regulation Of Mitotic Cell Cycle
Mitotic DNA Damage Checkpoint
Mitotic DNA Integrity Checkpoint
Aromatic Compound Catabolic Process
Negative Regulation Of Mitotic Cell Cycle
Cellular Response To Ionizing Radiation
Regulation Of Cell Cycle Phase Transition
Signal Transduction Involved In DNA Damage Checkpoint
Metabolic Process
Tagcloud
?
53bp1
accurately
atm
azd2281
brca1
brca2
characterizing
cyclina2
ddr
deficiencies
distngiushed
etoposide
functionality
genotoxins
h2ax
haploinsuffiency
hrr
joining
mechanistically
muted
nhej
normalize
parpi
pkcs
predisposition
proficient
readouts
scnp
temozolomide
Tagcloud (Difference)
?
53bp1
accurately
atm
azd2281
brca1
brca2
characterizing
cyclina2
ddr
deficiencies
distngiushed
etoposide
functionality
genotoxins
h2ax
haploinsuffiency
hrr
joining
mechanistically
muted
nhej
normalize
parpi
pkcs
predisposition
proficient
readouts
scnp
temozolomide
Tagcloud (Intersection)
?